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Lack of Effect of Lithium Carbonate in Patients With Glycogenosis Ib

Lack of Effect of Lithium Carbonate in Patients With Glycogenosis Ib Abstract • Lithium carbonate has been observed to induce neutrophilia in psychiatric patients and has been used in a number of childhood neutropenic disorders. We tried lithium carbonate in three children with glycogenosis Ib to see if the drug would alleviate the neutropenic complications of the disorder. Mean absolute neutrophil counts rose in one patient but not in the other two. Despite high-dosage schedules, serum lithium levels were highly erratic. Two patients developed potentially severe side effects, including polyuria, diarrhea, and altered mental status. One patient developed pneumonia despite a neutrophil count rise in response to therapy. Lithium carbonate is not useful in patients with glycogenosis Ib. (AJDC 1987;141:985-986) References 1. Senior B, Loridan L: Studies in liver glycogenosis, with particular reference to metabolism of intravenously administered glycerol . N Engl J Med 1968;279:958-965.Crossref 2. Ambruso DR, McCabe ERB, Anderson D, et al: Infectious and bleeding complications in patients with glycogenosis Ib . AJDC 1985;139: 691-697. 3. De Alarcon PA, Goldberg J, Nelson DA, et al: Lithium therapy in childhood neutropenia . J Pediatr 1983;102:149-152.Crossref 4. McCabe ERB, Melvin TR, O'Brien D, et al: Neutropenia in a patient with type 1B glycogen storage disease: In vitro response to lithium chloride . J Pediatr 1980;97:944-946.Crossref 5. Mahoney DH Jr, Anderson DC, Beaudet AL: Lithium carbonate therapy for neutropenia of glycogen storage disease type 1B , abstracted. Pediatr Res 1982;16:209A.Crossref 6. Anderson DC, Mace ML, Brinkley BR, et al: Recurrent infection in glycogenosis type Ib: Abnormal neutrophil motility related to impaired redistribution of adhesion sites . J Infect Dis 1981;143:447-459.Crossref 7. Gallicchio VS, Chen MG: Influence of lithium on proliferation of hematopoietic stem cells . Exp Hematol 1981;9:804-810. 8. Spitzar G, Verma DA, Barlogie B, et al: Possible mechanisms of action of lithium on augmentation of in vitro spontaneous myeloid colony formation . Cancer Res 1979;39:3215-3219. 9. Koletzko B, Wendel U, Bremer HJ: Lithium treatment of neutropenia in glycogen storage disease type Ib . J Pediatr 1986;109:902-904.Crossref 10. Seger R, Steinmann B, Tiefenauer L, et al: Glycogenosis Ib: Neutrophil microbicidal defects due to impaired hexose monophosphate shunt . Pediatr Res 1984;18:297-299.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

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Publisher
American Medical Association
Copyright
Copyright © 1987 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1987.04460090062025
Publisher site
See Article on Publisher Site

Abstract

Abstract • Lithium carbonate has been observed to induce neutrophilia in psychiatric patients and has been used in a number of childhood neutropenic disorders. We tried lithium carbonate in three children with glycogenosis Ib to see if the drug would alleviate the neutropenic complications of the disorder. Mean absolute neutrophil counts rose in one patient but not in the other two. Despite high-dosage schedules, serum lithium levels were highly erratic. Two patients developed potentially severe side effects, including polyuria, diarrhea, and altered mental status. One patient developed pneumonia despite a neutrophil count rise in response to therapy. Lithium carbonate is not useful in patients with glycogenosis Ib. (AJDC 1987;141:985-986) References 1. Senior B, Loridan L: Studies in liver glycogenosis, with particular reference to metabolism of intravenously administered glycerol . N Engl J Med 1968;279:958-965.Crossref 2. Ambruso DR, McCabe ERB, Anderson D, et al: Infectious and bleeding complications in patients with glycogenosis Ib . AJDC 1985;139: 691-697. 3. De Alarcon PA, Goldberg J, Nelson DA, et al: Lithium therapy in childhood neutropenia . J Pediatr 1983;102:149-152.Crossref 4. McCabe ERB, Melvin TR, O'Brien D, et al: Neutropenia in a patient with type 1B glycogen storage disease: In vitro response to lithium chloride . J Pediatr 1980;97:944-946.Crossref 5. Mahoney DH Jr, Anderson DC, Beaudet AL: Lithium carbonate therapy for neutropenia of glycogen storage disease type 1B , abstracted. Pediatr Res 1982;16:209A.Crossref 6. Anderson DC, Mace ML, Brinkley BR, et al: Recurrent infection in glycogenosis type Ib: Abnormal neutrophil motility related to impaired redistribution of adhesion sites . J Infect Dis 1981;143:447-459.Crossref 7. Gallicchio VS, Chen MG: Influence of lithium on proliferation of hematopoietic stem cells . Exp Hematol 1981;9:804-810. 8. Spitzar G, Verma DA, Barlogie B, et al: Possible mechanisms of action of lithium on augmentation of in vitro spontaneous myeloid colony formation . Cancer Res 1979;39:3215-3219. 9. Koletzko B, Wendel U, Bremer HJ: Lithium treatment of neutropenia in glycogen storage disease type Ib . J Pediatr 1986;109:902-904.Crossref 10. Seger R, Steinmann B, Tiefenauer L, et al: Glycogenosis Ib: Neutrophil microbicidal defects due to impaired hexose monophosphate shunt . Pediatr Res 1984;18:297-299.Crossref

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: Sep 1, 1987

References

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