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LABORATORY INFECTION WITH THE VIRUS OF LYMPHOCYTIC CHORIOMENINGITIS

LABORATORY INFECTION WITH THE VIRUS OF LYMPHOCYTIC CHORIOMENINGITIS Although many investigators have been actively engaged in experimental work with the virus of lymphocytic choriomeningitis or with infected animals, comparatively few have contracted the disease or, of those tested, few have developed neutralizing antibodies in their serum.1 Lépine and Sautter2 were first to report a laboratory infection of lymphocytic choriomeningitis. Virus was isolated from their patient's blood and urine, and complement fixing antibodies were demonstrated in the patient's serum during convalescence. The serums of 2 persons who had worked for two years with the same virus strain and infected animals failed to fix complement. Lépine and Sautter mention no attempt to detect virus neutralizing substances in their patient's serum. They believe that their patient became infected nine days before onset of symptoms by fragments of contaminated glass that were accidentally splattered into her eye during the process of grinding infected guinea pig tissues with powdered glass. More http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

LABORATORY INFECTION WITH THE VIRUS OF LYMPHOCYTIC CHORIOMENINGITIS

JAMA , Volume 120 (1) – Sep 5, 1942

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Publisher
American Medical Association
Copyright
Copyright © 1942 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.1942.82830360003008c
Publisher site
See Article on Publisher Site

Abstract

Although many investigators have been actively engaged in experimental work with the virus of lymphocytic choriomeningitis or with infected animals, comparatively few have contracted the disease or, of those tested, few have developed neutralizing antibodies in their serum.1 Lépine and Sautter2 were first to report a laboratory infection of lymphocytic choriomeningitis. Virus was isolated from their patient's blood and urine, and complement fixing antibodies were demonstrated in the patient's serum during convalescence. The serums of 2 persons who had worked for two years with the same virus strain and infected animals failed to fix complement. Lépine and Sautter mention no attempt to detect virus neutralizing substances in their patient's serum. They believe that their patient became infected nine days before onset of symptoms by fragments of contaminated glass that were accidentally splattered into her eye during the process of grinding infected guinea pig tissues with powdered glass. More

Journal

JAMAAmerican Medical Association

Published: Sep 5, 1942

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