Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You and Your Team.

Learn More →

KORSAKOFF'S SYNDROME: CLINICAL STUDY OF THE ALCOHOLIC FORM, WITH SPECIAL REGARD TO PROGNOSIS

KORSAKOFF'S SYNDROME: CLINICAL STUDY OF THE ALCOHOLIC FORM, WITH SPECIAL REGARD TO PROGNOSIS Abstract Much attention has been directed recently to the role of vitamin deficiency in the production of alcoholic polyneuritis,1 and there have been enthusiastic reports of the therapeutic value of the administration of vitamins. Most of these articles have dealt chiefly with the form of alcoholic polyneuritis not accompanied by mental changes. Polyneuritis and mental changes (Korsakoff's syndrome) associated with chronic alcoholism are usually considered to constitute a disease in which the prognosis is extremely poor, and with few exceptions2 the reports in the literature have dealt with the clinical and pathologic observations3 in cases in which the outcome was fatal. We thought it would be of value, therefore, to analyze the clinical records of a series of patients with this condition in an attempt to determine the mortality rate, the final clinical status of those who survived and the clinical factors of importance in regard to the References 1. Wechsler, I. S.: Etiology of Polyneuritis , Arch. Neurol. & Psychiat. 29:813 ( (April) ) 1933. 2. Strauss, M. B.: Am. J. M. Sc. 189:378, 1935. 3. Blankenhorn, M. A., and Spies, T. P.: Tr. A. Am. Physicians 50:164, 1935. 4. Jolliffe, N.; Colbert, C. N., and Joffe, P. M.: Am. J. M. Sc. 191:515, 1936. 5. Goodhart, R., and Jolliffe, N.: Effects of Vitamin (B1) Therapy on the Polyneuritis of Alcohol Addicts , J. A. M. A. 110:414 ( (Feb. 5) ) 1938. 6. Meyer, A.: Brain 24:47, 1901. 7. Marcus, H.: Svenska läk.-sällsk. handl. 51:159, 1926. 8. Gamper, E.: Deutsche Ztschr. f. Nervenh. 102:122, 1928. 9. Carmichael, E. A., and Stern, R. O.: Brain 54:189, 1931. 10. Bender, L., and Schilder, P.: Encephalopathia Alcoholica: Polioencephalitis Haemorrhagica Superior of Wernicke , Arch. Neurol. & Psychiat. 29:990 ( (May) ) 1933. 11. Nègre: Thesis, Lyon, 1929. 12. Lemierre, A.; Boltanski, E., and Justin-Besançon, L.: Bull. Acad. de méd. , Paris 105:676, 1931. 13. Seibert, H.: Monatschr. f. Psychiat. u. Neurol. 83:217, 1932. 14. Marchand, L., and Courtois, A.: Rev. neurol. 2:425, 1934. 15. Moore, M., and Gray, M. G.: New England J. Med. 217:381, 1937. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology & Psychiatry American Medical Association

KORSAKOFF'S SYNDROME: CLINICAL STUDY OF THE ALCOHOLIC FORM, WITH SPECIAL REGARD TO PROGNOSIS

Loading next page...
 
/lp/american-medical-association/korsakoff-s-syndrome-clinical-study-of-the-alcoholic-form-with-special-WzdeEp1U9F
Publisher
American Medical Association
Copyright
Copyright © 1939 American Medical Association. All Rights Reserved.
ISSN
0096-6754
DOI
10.1001/archneurpsyc.1939.02270170116006
Publisher site
See Article on Publisher Site

Abstract

Abstract Much attention has been directed recently to the role of vitamin deficiency in the production of alcoholic polyneuritis,1 and there have been enthusiastic reports of the therapeutic value of the administration of vitamins. Most of these articles have dealt chiefly with the form of alcoholic polyneuritis not accompanied by mental changes. Polyneuritis and mental changes (Korsakoff's syndrome) associated with chronic alcoholism are usually considered to constitute a disease in which the prognosis is extremely poor, and with few exceptions2 the reports in the literature have dealt with the clinical and pathologic observations3 in cases in which the outcome was fatal. We thought it would be of value, therefore, to analyze the clinical records of a series of patients with this condition in an attempt to determine the mortality rate, the final clinical status of those who survived and the clinical factors of importance in regard to the References 1. Wechsler, I. S.: Etiology of Polyneuritis , Arch. Neurol. & Psychiat. 29:813 ( (April) ) 1933. 2. Strauss, M. B.: Am. J. M. Sc. 189:378, 1935. 3. Blankenhorn, M. A., and Spies, T. P.: Tr. A. Am. Physicians 50:164, 1935. 4. Jolliffe, N.; Colbert, C. N., and Joffe, P. M.: Am. J. M. Sc. 191:515, 1936. 5. Goodhart, R., and Jolliffe, N.: Effects of Vitamin (B1) Therapy on the Polyneuritis of Alcohol Addicts , J. A. M. A. 110:414 ( (Feb. 5) ) 1938. 6. Meyer, A.: Brain 24:47, 1901. 7. Marcus, H.: Svenska läk.-sällsk. handl. 51:159, 1926. 8. Gamper, E.: Deutsche Ztschr. f. Nervenh. 102:122, 1928. 9. Carmichael, E. A., and Stern, R. O.: Brain 54:189, 1931. 10. Bender, L., and Schilder, P.: Encephalopathia Alcoholica: Polioencephalitis Haemorrhagica Superior of Wernicke , Arch. Neurol. & Psychiat. 29:990 ( (May) ) 1933. 11. Nègre: Thesis, Lyon, 1929. 12. Lemierre, A.; Boltanski, E., and Justin-Besançon, L.: Bull. Acad. de méd. , Paris 105:676, 1931. 13. Seibert, H.: Monatschr. f. Psychiat. u. Neurol. 83:217, 1932. 14. Marchand, L., and Courtois, A.: Rev. neurol. 2:425, 1934. 15. Moore, M., and Gray, M. G.: New England J. Med. 217:381, 1937.

Journal

Archives of Neurology & PsychiatryAmerican Medical Association

Published: May 1, 1939

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$499/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month