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Ketamine for the Treatment of Depression

Ketamine for the Treatment of Depression Letters depression. For example, if a simple bolus injection of 0.5 These agents can also be used prophylactically prior to the ad- mg/kg is equally effective as a 40-minute infusion, then that ministration of ketamine; glycopyrrolate might be a proper would be much more convenient. It is also possible that higher choice owing to not having undesirable central nervous sys- doses than 0.5 mg/kg may be more effective. Such doses may tem effects. If laryngospasm occurs, in addition to the ad- require more intensive cardiac and respiratory monitoring, but ministration of pharmacological interventions, the Larson ma- if they are more effective, then that would be quite helpful to neuver can be applied ; it is easy to perform and can instantly the chronically treatment refractory patients who are now pre- break the laryngospasm. senting for this medication. Furthermore, ketamine should be used with extreme cau- Sanacora et al refer to 0.5 mg/kg over 40 minutes as the tion in patients with increased intracranial pressure or those “standard” dose and indicate that other dosages or infusion with intracranial mass lesions, as it might increase intracra- rates necessitate special informed consent discussion with the nial pressure and consequently add to the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Psychiatry American Medical Association

Ketamine for the Treatment of Depression

JAMA Psychiatry , Volume 74 (9) – Sep 12, 2017

Ketamine for the Treatment of Depression

Abstract

Letters depression. For example, if a simple bolus injection of 0.5 These agents can also be used prophylactically prior to the ad- mg/kg is equally effective as a 40-minute infusion, then that ministration of ketamine; glycopyrrolate might be a proper would be much more convenient. It is also possible that higher choice owing to not having undesirable central nervous sys- doses than 0.5 mg/kg may be more effective. Such doses may tem effects. If laryngospasm occurs, in addition to the ad-...
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Publisher
American Medical Association
Copyright
Copyright 2017 American Medical Association. All Rights Reserved.
ISSN
2168-622X
eISSN
2168-6238
DOI
10.1001/jamapsychiatry.2017.1779
Publisher site
See Article on Publisher Site

Abstract

Letters depression. For example, if a simple bolus injection of 0.5 These agents can also be used prophylactically prior to the ad- mg/kg is equally effective as a 40-minute infusion, then that ministration of ketamine; glycopyrrolate might be a proper would be much more convenient. It is also possible that higher choice owing to not having undesirable central nervous sys- doses than 0.5 mg/kg may be more effective. Such doses may tem effects. If laryngospasm occurs, in addition to the ad- require more intensive cardiac and respiratory monitoring, but ministration of pharmacological interventions, the Larson ma- if they are more effective, then that would be quite helpful to neuver can be applied ; it is easy to perform and can instantly the chronically treatment refractory patients who are now pre- break the laryngospasm. senting for this medication. Furthermore, ketamine should be used with extreme cau- Sanacora et al refer to 0.5 mg/kg over 40 minutes as the tion in patients with increased intracranial pressure or those “standard” dose and indicate that other dosages or infusion with intracranial mass lesions, as it might increase intracra- rates necessitate special informed consent discussion with the nial pressure and consequently add to the

Journal

JAMA PsychiatryAmerican Medical Association

Published: Sep 12, 2017

References