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KERNICTERUS

KERNICTERUS WITH the advent of more detailed knowledge concerning the pathogenesis and treatment of erythroblastosis fetalis, interest has been focused on the possible untoward effects of a successful therapeutic regimen that may result in a live but helpless infant with kernicterus. The term "kernicterus" was devised by Schmorl1 in 1903 in referring to what Orth1 had called "nuclear jaundice" in 1875. Orth described a primary necrosis of the brain associated with secondary bile staining and degeneration of the ganglion cells. In 1907 Bencke summarized the prevailing views concerning the relationship between cerebral injury and kernicterus, and it is of interest that one of these theories, that damage to ganglion cells is caused by ischemia (or trauma), in which area of damage there is a subsequent pigmentation, has gained wide acceptance among present day workers in the field. In 1932 Diamond and his colleagues2 linked together as a single http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American journal of diseases of children American Medical Association

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Publisher
American Medical Association
Copyright
Copyright © 1947 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0096-8994
eISSN
1538-3628
DOI
10.1001/archpedi.1947.02020410002001
Publisher site
See Article on Publisher Site

Abstract

WITH the advent of more detailed knowledge concerning the pathogenesis and treatment of erythroblastosis fetalis, interest has been focused on the possible untoward effects of a successful therapeutic regimen that may result in a live but helpless infant with kernicterus. The term "kernicterus" was devised by Schmorl1 in 1903 in referring to what Orth1 had called "nuclear jaundice" in 1875. Orth described a primary necrosis of the brain associated with secondary bile staining and degeneration of the ganglion cells. In 1907 Bencke summarized the prevailing views concerning the relationship between cerebral injury and kernicterus, and it is of interest that one of these theories, that damage to ganglion cells is caused by ischemia (or trauma), in which area of damage there is a subsequent pigmentation, has gained wide acceptance among present day workers in the field. In 1932 Diamond and his colleagues2 linked together as a single

Journal

American journal of diseases of childrenAmerican Medical Association

Published: Jun 1, 1947

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