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Abstract Keratoderma blennorrhagicum is a rare skin disease. Only seventy cases are on record, of which eleven have been described in the American literature. In the following article, we have endeavored to clarify the confusion that still exists regarding pathogenesis, nomenclature and relationship to other similar eruptions. Buschke,1 in his monograph published in 1899, divided all gonorrheal manifestations on the skin into four groups: (1) simple erythemas, (2) urticaria and erythema nodosum, (3) hemorrhagic and bullous exanthems and (4) hyperkeratoses. This classification, though slightly schematic, has been generally accepted. The most important and characteristic group is the one of gonorrheal hyperkeratoses. On the basis of carefully studied cases, Buschke concludes that the hyperkeratoses should be strictly separated from other gonorrheal manifestations and should be classified as a separate clinical and histologic entity. The reasons supporting his conclusions are as follows: First, there are no transitory clinical or histologic manifestations which References 1. Buschke: Exantheme bei Gonorrhoe , Arch. f. Dermat. u. Syph. 48:181, 1899.Crossref 2. Vidal: Eruption generalisée et symetrique de croutes cornées avec chute des ongles d'origine blennorrhagique, coincidant avec une polyarthritic de même nature. Recidive a la suite d'une guerison de la premiere maladie , Ann. de dermat. et syph. 4:3, 1893. 3. Chauffard: Infection blennorrhagique avec Productions cornées de la peau , Bull. et mém. Soc. méd. d. hôp. de Paris 14:93, 1897. 4. Baerman: Ueber hyperkeratotische Exantheme bei schweren gonorrhoischen Infectionen , Arch. f. Dermat. u. Syph. 69:363, 1904.Crossref 5. Sobotka: Pustulos-hyperkeratotisches Exantheme bei gonorrhoischen Allgemeinerkrankung , Dermat. Wchnschr. 56:181, 1913. 6. Keim: The Histogenesis of Keratoderma blennorrhagicum , Arch. Dermat. u. Syph. 9:435 ( (April) ) 1924. 7. Robert: Contribution a l'etudedes troubles trophiques cutanée dans la blennorrhagie, These de Paris, April 28, 1897 8. Ann. de dermat. et syph. 8:1053, 1897. 9. Lee: Keratodermia Blennorrhagica , Edinburgh M. J. 28:99 ( (April) ) 1922. 10. Isaac: A Case of Keratodermia Blennorrhagica in a Woman , Brit. J. Dermat. 32:195, 1920.Crossref 11. Bogrow: Ueber gonorrhoischen Keratosen , Arch. f. Dermat. u. Syph. 143:44, 1923.Crossref 12. Roth: Zur Kasuistik des hyperkeratotischen gonorrhoischen Exantheme , München med. Wchnschr. 52:104, 1905. 13. Mumford: A Mild Case of Keratodermia Blennorrhagicum . Brit. J. Dermat. 35:462, 1923.Crossref 14. Oelze: Ueber Keratosis gonorrhoica , Arch. f. Dermat. u. Syph. 144:1, 1923.Crossref 15. Du Bois: Keratoses blennorrhagiques on dermatites gonococciques , Acta derm.-venereol 5:1, 1924. 16. Bussallac Louigi: Sapra un caso d'ipercheratosi blenorrhagica , Pathologica 16:365, 1924. 17. Rille: Keratosis gonorrhoica , Deutsche med. Wchnschr. 50:1568, 1924. 18. Sainz de Aja: Keratoderma blennorrhagicum , Actas dermosifilagr. 17:103, 1925. (Spanish) 19. Willmott: "Keratodermie blennorrhagique" (Vidal) , Arch. Dermat. et Syph. 13:17, 1926.Crossref 20. Garcia Faure: Keratodermia blennorrhagica , Pseusa méd. Argentina 20:739, 1925. (Spanish) 21. Olivet: Hyperkeratose und Thrombophlebitis bei Gonorrhoe , Med. Klin. 24:916, 1926. 22. Scholtz: A Syndrome of Blennorrhagic Keratoderma , Arch. Dermat. & Syph. 15:165, 1927. 23. Bulkin: Keratosis blennorrhagic a. Ruskij Westnik Dermat. 5:2, 1927. 24. Wadsack: Ein gonorrhea Exanthem , Berl. Klin. Wchnschr. 43:966, 1906. 25. Adamson: Keratodermia Blennorrhagica: Is It a Form of Psoriasis? Brit. J. Dermat. 32:183, 1920. 26. Buschke: Ueber universell symmetrische entzündliche Hyperkeratosen auf uro-septischer und arthritischer Basis , Arch. f. Dermat. u. Syph. 113:223, 1912. 27. Falk: Psoriasis arthropatica (einschliesslich der sog. hyperkeratotischen Exantheme bei gonorrhoischen Gelenkerkrankungen) , Arch. f. Dermat. u. Syph. 129:299, 1921.
Archives of Dermatology and Syphilology – American Medical Association
Published: Dec 1, 1927
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