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J Amer Geriat Soc 18:792-797 1970 Effects of and Small Doses of (Oct) Large Hydrochlorothiazide in Patients—P. J. R. I. Ogilvie. Hypertensive McLeod, Serum in 60 with histologically protein analysis patients and J. General Montreal) Ruedy (Montreal Hosp, confirmed Alzheimer's disease and in 60 others (group A) with clinical dementia and evidence of dif¬ radiographie Clin Pharmacol Ther 11:733-739 1970 (Sept-Oct) cerebral with Alzheimer's disease fuse atrophy compatible the effect of doses of To antihypertensive investigate and increase revealed a decrease in albumin an (group B) maximal HCT than that diuresis, 21 hy¬ greater producing in and alpha-1 antitrypsin, alpha-2 hapto- macroglobulin were studied. These were pertensive outpatients patients fractions. These abnormalities occurred in of globin 66% selected from a and included those who large group only two of these but in of a third group pa¬ groups, only 13% occasions failed obtain blood on had to previous adequate tients with dementia of the non-Alzheimer In addi¬ type. stabili¬ control from diuretic alone. After pressure therapy the values for were tion, highest alpha-2 macroglobulin zation on all received HCT 150 placebo, patients mg/day found in and B. The of A possible relationship groups concentra¬ for weeks. of serum HCT
JAMA – American Medical Association
Published: Dec 14, 1970
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