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Jaundice Following the Administration of Niacin

Jaundice Following the Administration of Niacin CHOLESTATIC jaundice is a recognized complication of massive doses of niacin.1 Recovery usually occurs after the therapy is discontinued. The present case is of interest in that the dosage was moderate (750 mg daily) and the duration relatively short (less than three months). Nevertheless, a reaction to niacin appears to be a reasonable explanation of the patient's jaundice. Report of a Case A 69-year-old white man became bored with his inactive retirement and attempted suicide by car exhaust fumes. Five months earlier he had had an apparent stroke and developed a parkinsonian tremor, difficulty in walking, episodic memory difficulties, and increasing depression. He was lethargic but not comatose when admitted to a general hospital for emergency treatment after his suicide attempt, and three days later he was transferred to a psychiatric hospital. Findings were consistent with organic brain syndrome, with psychological tests indicating intellectual deterioration and right-hemisphere damage. The http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Jaundice Following the Administration of Niacin

Sugerman, A. Arthur; Clark, Charles G.
JAMA , Volume 228 (2) – Apr 8, 1974
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Jaundice Following the Administration of Niacin

Abstract


CHOLESTATIC jaundice is a recognized complication of massive doses of niacin.1 Recovery usually occurs after the therapy is discontinued. The present case is of interest in that the dosage was moderate (750 mg daily) and the duration relatively short (less than three months). Nevertheless, a reaction to niacin appears to be a reasonable explanation of the patient's jaundice.

Report of a Case
A 69-year-old white man became bored with his inactive retirement and attempted suicide by car...
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Publisher
American Medical Association
Copyright
Copyright © 1974 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.1974.03230270046027
Publisher site
See Article on Publisher Site

Abstract

CHOLESTATIC jaundice is a recognized complication of massive doses of niacin.1 Recovery usually occurs after the therapy is discontinued. The present case is of interest in that the dosage was moderate (750 mg daily) and the duration relatively short (less than three months). Nevertheless, a reaction to niacin appears to be a reasonable explanation of the patient's jaundice. Report of a Case A 69-year-old white man became bored with his inactive retirement and attempted suicide by car exhaust fumes. Five months earlier he had had an apparent stroke and developed a parkinsonian tremor, difficulty in walking, episodic memory difficulties, and increasing depression. He was lethargic but not comatose when admitted to a general hospital for emergency treatment after his suicide attempt, and three days later he was transferred to a psychiatric hospital. Findings were consistent with organic brain syndrome, with psychological tests indicating intellectual deterioration and right-hemisphere damage. The

Journal

JAMA – American Medical Association

Published: Apr 8, 1974

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