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Ivory-Colored Papules in a Young Boy

Ivory-Colored Papules in a Young Boy Abstract REPORT OF A CASE A 6.5-year-old Arabic boy was referred to the genetics clinic at age 24 months for evaluation of dysmorphic facial features and recurrent upper respiratory tract infections. The patient had reached all developmental milestones without delay. He was currently in the first grade and exhibited no gross or fine motor handicaps. The patient's 4.5-year-old brother had the same syndrome.For age, the patient's height was less than the fifth percentile, his weight in the 75th percentile, and his head circumference in the 95th percentile. Multiple, ivory-colored papules (<0.5 cm) were observed over and between both scapulae (Figure 1). The patient also presented with dry, coarse, thickened skin and truncal hypertrichosis. Frontal bossing, large thickened eyebrows, a flat nasal bridge, and micrognathia were all noted. He had small permanent teeth and a large protruding tongue. His abdomen was protuberant and the liver span was 8 cm, consistent with References 1. Neufeld EF, Muenzer J. The mucopolysaccharide storage disease . In Scriver CR, Beaudet AV, Sly WS, et al, eds. The Metabolic Basis of Inherited Disease . 6th ed. New York, NY: McGraw-Hill International Book Co; 1989:1565. 2. Young ID, Harper PS. Incidence of Hunter's syndrome . Hum Genet. 1982;60: 391-392.Crossref 3. Schaap T, Bach G. Incidence of mucopolysaccharidoses in Israel: is Hunter's syndrome a Jewish disease? Hum Genet. 1980;56:221.Crossref 4. Muenzer J. Mucopolysaccharidoses . Adv Pediatr. 1986;33:269-286. 5. Mallory S, Krafchik B. Hunter syndrome (mucopolysaccharidosis) . Pediatr Dermatol. 1991;7:150. 6. Prystowsky S, Maumenee I, Freeman R, et al. A cutaneous marker in Hunter's syndrome . Arch Dermatol. 1977;113:602-605.Crossref 7. Spranger J, Cantz M, Gehler J. Mucopolysaccharidosis II (Hunter's disease) with corneal opacities . Eur J Pediatr. 1978;129:11-16.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Ivory-Colored Papules in a Young Boy

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Publisher
American Medical Association
Copyright
Copyright © 1995 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1995.01690130083015
Publisher site
See Article on Publisher Site

Abstract

Abstract REPORT OF A CASE A 6.5-year-old Arabic boy was referred to the genetics clinic at age 24 months for evaluation of dysmorphic facial features and recurrent upper respiratory tract infections. The patient had reached all developmental milestones without delay. He was currently in the first grade and exhibited no gross or fine motor handicaps. The patient's 4.5-year-old brother had the same syndrome.For age, the patient's height was less than the fifth percentile, his weight in the 75th percentile, and his head circumference in the 95th percentile. Multiple, ivory-colored papules (<0.5 cm) were observed over and between both scapulae (Figure 1). The patient also presented with dry, coarse, thickened skin and truncal hypertrichosis. Frontal bossing, large thickened eyebrows, a flat nasal bridge, and micrognathia were all noted. He had small permanent teeth and a large protruding tongue. His abdomen was protuberant and the liver span was 8 cm, consistent with References 1. Neufeld EF, Muenzer J. The mucopolysaccharide storage disease . In Scriver CR, Beaudet AV, Sly WS, et al, eds. The Metabolic Basis of Inherited Disease . 6th ed. New York, NY: McGraw-Hill International Book Co; 1989:1565. 2. Young ID, Harper PS. Incidence of Hunter's syndrome . Hum Genet. 1982;60: 391-392.Crossref 3. Schaap T, Bach G. Incidence of mucopolysaccharidoses in Israel: is Hunter's syndrome a Jewish disease? Hum Genet. 1980;56:221.Crossref 4. Muenzer J. Mucopolysaccharidoses . Adv Pediatr. 1986;33:269-286. 5. Mallory S, Krafchik B. Hunter syndrome (mucopolysaccharidosis) . Pediatr Dermatol. 1991;7:150. 6. Prystowsky S, Maumenee I, Freeman R, et al. A cutaneous marker in Hunter's syndrome . Arch Dermatol. 1977;113:602-605.Crossref 7. Spranger J, Cantz M, Gehler J. Mucopolysaccharidosis II (Hunter's disease) with corneal opacities . Eur J Pediatr. 1978;129:11-16.Crossref

Journal

Archives of Dermatology – American Medical Association

Published: Jan 1, 1995

References

  • The Metabolic Basis of Inherited Disease
    Neufeld EF, Muenzer J
  • Incidence of Hunter's syndrome
    Young ID, Harper PS
  • Incidence of mucopolysaccharidoses in Israel: is Hunter's syndrome a Jewish disease?
    Schaap T, Bach G
  • Mucopolysaccharidoses
    Muenzer J
  • Hunter syndrome (mucopolysaccharidosis)
    Mallory S, Krafchik B
  • A cutaneous marker in Hunter's syndrome
    Prystowsky S, Maumenee I, Freeman R, et al
  • Mucopolysaccharidosis II (Hunter's disease) with corneal opacities
    Spranger J, Cantz M, Gehler J