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Itraconazole Therapy for Human Immunodeficiency Virus-Associated Eosinophilic Folliculitis

Itraconazole Therapy for Human Immunodeficiency Virus-Associated Eosinophilic Folliculitis Abstract In treating human immunodeficiency virus (HIV)— associated eosinophilic folliculitis (EF), potent topical steroids, systemic corticosteroids, antihistamines, and UV light phototherapy (including psoralen plus UV-A) exhibit therapeutic benefit.1-3 An open trial of itraconazole for EF was undertaken following anecdotal reports from physicians in Europe that it dramatically improved HIV-associated pruritus. Patients and Methods. Twenty-eight patients were entered in the study at two centers: the private practice of one of us (M.C.) (center 1) and the dermatology clinics of the University of California—San Francisco (center 2). At center 1, if the history and physical findings were compatible with eosinophilic folliculitis, skin biopsies were performed and itraconazole therapy (200 mg twice a day) was immediately begun. Eleven of 12 patients who underwent a biopsy had EF. At center 2, after histologically confirming the diagnosis, treatment was begun. The first three patients received a dose of 100 mg/d. Thereafter, the initial dose was References 1. Rosenthal D, LeBoit PE, Klumpp L, Berger TG. Human immunodeficiency virus—associated eosinophilic folliculitis . Arch Dermatol. 1991;127:206-209.Crossref 2. Pardo RJ, Bogaert MA, Penneys NS, Byrne GE, Ruiz P. UVB phototherapy of the pruritic papular eruption of the acquired immunodeficiency syndrome . J Am Acad Dermatol. 1992;26:423-428.Crossref 3. Buchness MR, Lim HW, Hatcher VA, Sanchez M, Soter NA. Eosinophilic pustular folliculitis in the acquired immunodeficiency syndrome: treatment with ultraviolet B phototherapy . N Engl J Med. 1988;318:1183-1186.Crossref 4. McCalmont TH, Altemus D, Lobo D, Brandt A, Maurer T, Berger TG. Eosinophilic folliculitis: the histologic spectrum . In: Program and abstracts of Plenary Session II, 30th annual meeting of The American Society of Dermatopathology; December 2-4, 1992, San Francisco, Calif. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Itraconazole Therapy for Human Immunodeficiency Virus-Associated Eosinophilic Folliculitis

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Publisher
American Medical Association
Copyright
Copyright © 1995 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1995.01690150124031
Publisher site
See Article on Publisher Site

Abstract

Abstract In treating human immunodeficiency virus (HIV)— associated eosinophilic folliculitis (EF), potent topical steroids, systemic corticosteroids, antihistamines, and UV light phototherapy (including psoralen plus UV-A) exhibit therapeutic benefit.1-3 An open trial of itraconazole for EF was undertaken following anecdotal reports from physicians in Europe that it dramatically improved HIV-associated pruritus. Patients and Methods. Twenty-eight patients were entered in the study at two centers: the private practice of one of us (M.C.) (center 1) and the dermatology clinics of the University of California—San Francisco (center 2). At center 1, if the history and physical findings were compatible with eosinophilic folliculitis, skin biopsies were performed and itraconazole therapy (200 mg twice a day) was immediately begun. Eleven of 12 patients who underwent a biopsy had EF. At center 2, after histologically confirming the diagnosis, treatment was begun. The first three patients received a dose of 100 mg/d. Thereafter, the initial dose was References 1. Rosenthal D, LeBoit PE, Klumpp L, Berger TG. Human immunodeficiency virus—associated eosinophilic folliculitis . Arch Dermatol. 1991;127:206-209.Crossref 2. Pardo RJ, Bogaert MA, Penneys NS, Byrne GE, Ruiz P. UVB phototherapy of the pruritic papular eruption of the acquired immunodeficiency syndrome . J Am Acad Dermatol. 1992;26:423-428.Crossref 3. Buchness MR, Lim HW, Hatcher VA, Sanchez M, Soter NA. Eosinophilic pustular folliculitis in the acquired immunodeficiency syndrome: treatment with ultraviolet B phototherapy . N Engl J Med. 1988;318:1183-1186.Crossref 4. McCalmont TH, Altemus D, Lobo D, Brandt A, Maurer T, Berger TG. Eosinophilic folliculitis: the histologic spectrum . In: Program and abstracts of Plenary Session II, 30th annual meeting of The American Society of Dermatopathology; December 2-4, 1992, San Francisco, Calif.

Journal

Archives of DermatologyAmerican Medical Association

Published: Mar 1, 1995

References