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Isoproterenol, Hemodynamics and Acid-Base Alterations

Isoproterenol, Hemodynamics and Acid-Base Alterations Abstract Much attention has been directed in recent years to the effects of altered pH and partial pressure of arterial carbon dioxide (Pco2) on the action of exogenous catecholamines and other cardiotonic drugs in the presence of hemodynamic shock.1,2 Few references, however, are available regarding the action of isoproterenol hydrochloride in the presence of an altered acid-base status. This laboratory study utilized an experimental format previously used to define the hemodynamic effects of altered pH and Pco23 and adds to it evaluation of the hemodynamic response to a single 100μg injection of isoproterenol hydrochloride. The ultimate aim of the study was to obtain more data on the mode of action of isoproterenol so that its clinical application could be better appreciated. Methods Male holstein calves (mean weight, 63 kg [138.6 lb]) were lightly anesthetized with ether and complete respiratory paralysis obtained with an intravenous injection of 20 References 1. Andersen, M.N.; Border, J.R.; and Mouritzer, C.V.: Acidoses, Catecholamines and Cardiovascular Dynamics: When Does Acidosis Require Correction? , Ann Surg 166:344-353 ( (Oct) ) 1961.Crossref 2. Carey, J.S., et al: Cardiovascular Function in Shock, Responses to Volume Loading and Isoproterenol Infusion , Circulation 35:327-341 ( (March) ) 1967.Crossref 3. Klocke, F.J., et al: An Intrinsic Adrenergic Vasodilator Mechanism in the Coronary Vascular Bed of the Dog , Circ Res 16:376-387 ( (April) ) 1965.Crossref 4. Rushmer, R.F.: Cardiovascular Dynamics , ed 2, London: W. B. Saunders Co., 1961, pp 216-218. 5. Gashell, W.H.: The Involuntary Nervous System , New York: Longmans, Green & Co., Ltd., 1916. 6. Ahlquist, R.P.: Study of the Adrenotropic Receptors , Amer J Physiol 153:586-603 ( (April) ) 1948. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

Isoproterenol, Hemodynamics and Acid-Base Alterations

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Publisher
American Medical Association
Copyright
Copyright © 1969 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1969.01340180068014
Publisher site
See Article on Publisher Site

Abstract

Abstract Much attention has been directed in recent years to the effects of altered pH and partial pressure of arterial carbon dioxide (Pco2) on the action of exogenous catecholamines and other cardiotonic drugs in the presence of hemodynamic shock.1,2 Few references, however, are available regarding the action of isoproterenol hydrochloride in the presence of an altered acid-base status. This laboratory study utilized an experimental format previously used to define the hemodynamic effects of altered pH and Pco23 and adds to it evaluation of the hemodynamic response to a single 100μg injection of isoproterenol hydrochloride. The ultimate aim of the study was to obtain more data on the mode of action of isoproterenol so that its clinical application could be better appreciated. Methods Male holstein calves (mean weight, 63 kg [138.6 lb]) were lightly anesthetized with ether and complete respiratory paralysis obtained with an intravenous injection of 20 References 1. Andersen, M.N.; Border, J.R.; and Mouritzer, C.V.: Acidoses, Catecholamines and Cardiovascular Dynamics: When Does Acidosis Require Correction? , Ann Surg 166:344-353 ( (Oct) ) 1961.Crossref 2. Carey, J.S., et al: Cardiovascular Function in Shock, Responses to Volume Loading and Isoproterenol Infusion , Circulation 35:327-341 ( (March) ) 1967.Crossref 3. Klocke, F.J., et al: An Intrinsic Adrenergic Vasodilator Mechanism in the Coronary Vascular Bed of the Dog , Circ Res 16:376-387 ( (April) ) 1965.Crossref 4. Rushmer, R.F.: Cardiovascular Dynamics , ed 2, London: W. B. Saunders Co., 1961, pp 216-218. 5. Gashell, W.H.: The Involuntary Nervous System , New York: Longmans, Green & Co., Ltd., 1916. 6. Ahlquist, R.P.: Study of the Adrenotropic Receptors , Amer J Physiol 153:586-603 ( (April) ) 1948.

Journal

Archives of SurgeryAmerican Medical Association

Published: Dec 1, 1969

References