Abstract Much attention has been directed in recent years to the effects of altered pH and partial pressure of arterial carbon dioxide (Pco2) on the action of exogenous catecholamines and other cardiotonic drugs in the presence of hemodynamic shock.1,2 Few references, however, are available regarding the action of isoproterenol hydrochloride in the presence of an altered acid-base status. This laboratory study utilized an experimental format previously used to define the hemodynamic effects of altered pH and Pco23 and adds to it evaluation of the hemodynamic response to a single 100μg injection of isoproterenol hydrochloride. The ultimate aim of the study was to obtain more data on the mode of action of isoproterenol so that its clinical application could be better appreciated. Methods Male holstein calves (mean weight, 63 kg [138.6 lb]) were lightly anesthetized with ether and complete respiratory paralysis obtained with an intravenous injection of 20 References 1. Andersen, M.N.; Border, J.R.; and Mouritzer, C.V.: Acidoses, Catecholamines and Cardiovascular Dynamics: When Does Acidosis Require Correction? , Ann Surg 166:344-353 ( (Oct) ) 1961.Crossref 2. Carey, J.S., et al: Cardiovascular Function in Shock, Responses to Volume Loading and Isoproterenol Infusion , Circulation 35:327-341 ( (March) ) 1967.Crossref 3. Klocke, F.J., et al: An Intrinsic Adrenergic Vasodilator Mechanism in the Coronary Vascular Bed of the Dog , Circ Res 16:376-387 ( (April) ) 1965.Crossref 4. Rushmer, R.F.: Cardiovascular Dynamics , ed 2, London: W. B. Saunders Co., 1961, pp 216-218. 5. Gashell, W.H.: The Involuntary Nervous System , New York: Longmans, Green & Co., Ltd., 1916. 6. Ahlquist, R.P.: Study of the Adrenotropic Receptors , Amer J Physiol 153:586-603 ( (April) ) 1948.
Archives of Surgery – American Medical Association
Published: Dec 1, 1969