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ISONIAZID AND STREPTOMYCIN IN THE TREATMENT OF PULMONARY TUBERCULOSIS: A PRELIMINARY REPORT

ISONIAZID AND STREPTOMYCIN IN THE TREATMENT OF PULMONARY TUBERCULOSIS: A PRELIMINARY REPORT Abstract Clinical studies with isoniazid and related compounds have demonstrated antituberculous activity of high magnitude and thus confirmed results of in vitro and in vivo investigations. Particularly significant are the evaluations recorded by Selikoff, Robitzek, and Ornstein1 on 166 patients with pulmonary and extra pulmonary tuberculosis treated with isoniazid or iproniazid alone, and those of Clark and co-workers2 on 14 patients with miliary and meningeal tuberculosis treated with isoniazid alone. These authors suggest that preliminary studies with isoniazid and iproniazid reveal therapeutic efficacy equal or superior to that observed with streptomycin employed singly. Treatment of 61 patients with moderately or far-advanced pulmonary tuberculosis at Fitzsimons Army Hospital with 150 or 300 mg. of isoniazid alone daily for four to eight months resulted in observations essentially in accord with the views expressed above.3 Symptomatic response was uniformly favorable and was supported by objective improvement as measured by serial chest References 1. Selikoff, I. J.; Robitzek, E. H., and Ornstein, G. G.: Treatment of Pulmonary Tuberculosis with Hydrazide Derivatives of Isonicotinic Acid , J. A. M. A. 150:978 ( (Nov. 8) ) 1952.Crossref 2. Clark, C. M., and others: Isoniazid (Isonicotinic Acid Hydrazide) in the Treatment of Miliary and Meningeal Tuberculosis , Am. Rev. Tuberc. 66:391 ( (Oct.) ) 1952. 3. Tempel, C. W.: Present Status of Specific Drug Treatment of Tuberculosis , J. A. M. A. 150:1165 ( (Nov. 22) ) 1952.Crossref 4. Pitts, F. W., and others: Isoniazid Therapy in Pulmonary Tuberculosis, A Preliminary Report , U. S. Armed Forces Med. J. 4:1 ( (Jan.) ) 1953. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

ISONIAZID AND STREPTOMYCIN IN THE TREATMENT OF PULMONARY TUBERCULOSIS: A PRELIMINARY REPORT

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References (6)

Publisher
American Medical Association
Copyright
Copyright © 1953 American Medical Association. All Rights Reserved.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.1953.03690100004002
Publisher site
See Article on Publisher Site

Abstract

Abstract Clinical studies with isoniazid and related compounds have demonstrated antituberculous activity of high magnitude and thus confirmed results of in vitro and in vivo investigations. Particularly significant are the evaluations recorded by Selikoff, Robitzek, and Ornstein1 on 166 patients with pulmonary and extra pulmonary tuberculosis treated with isoniazid or iproniazid alone, and those of Clark and co-workers2 on 14 patients with miliary and meningeal tuberculosis treated with isoniazid alone. These authors suggest that preliminary studies with isoniazid and iproniazid reveal therapeutic efficacy equal or superior to that observed with streptomycin employed singly. Treatment of 61 patients with moderately or far-advanced pulmonary tuberculosis at Fitzsimons Army Hospital with 150 or 300 mg. of isoniazid alone daily for four to eight months resulted in observations essentially in accord with the views expressed above.3 Symptomatic response was uniformly favorable and was supported by objective improvement as measured by serial chest References 1. Selikoff, I. J.; Robitzek, E. H., and Ornstein, G. G.: Treatment of Pulmonary Tuberculosis with Hydrazide Derivatives of Isonicotinic Acid , J. A. M. A. 150:978 ( (Nov. 8) ) 1952.Crossref 2. Clark, C. M., and others: Isoniazid (Isonicotinic Acid Hydrazide) in the Treatment of Miliary and Meningeal Tuberculosis , Am. Rev. Tuberc. 66:391 ( (Oct.) ) 1952. 3. Tempel, C. W.: Present Status of Specific Drug Treatment of Tuberculosis , J. A. M. A. 150:1165 ( (Nov. 22) ) 1952.Crossref 4. Pitts, F. W., and others: Isoniazid Therapy in Pulmonary Tuberculosis, A Preliminary Report , U. S. Armed Forces Med. J. 4:1 ( (Jan.) ) 1953.

Journal

JAMA – American Medical Association

Published: Jul 4, 1953

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