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Sperling RS Connor EM (1994)
Reduction of maternal-infant transmission of human immunodeficiency virus type 1 with zidovudine treatment.N Engl J Med, 331
Alejo Erice, D. Mayers, D. Strike, K. Sannerud, F. McCutchan, Keith Henry, H. Balfour (1993)
Brief report: primary infection with zidovudine-resistant human immunodeficiency virus type 1.The New England journal of medicine, 328 16
E. Connor, R. Sperling, R. Gelber, P. Kiselev, G. Scott, M. O'sullivan, Russell Vandyke, M. Bey, W. Shearer, R. Jacobson, E. Jiménez, E. O’neill, B. Bazin, J. Delfraissy, M. Culnane, R. Coombs, M. Elkins, J. Moye, P. Stratton, J. Balsley (1994)
Reduction of maternal-infant transmission of human immunodeficiency virus type 1 with zidovudine treatment. Pediatric AIDS Clinical Trials Group Protocol 076 Study Group.The New England journal of medicine, 331 18
J. Gerberding (1995)
Management of occupational exposures to blood-borne viruses.The New England journal of medicine, 332 7
Desmoulins C Coutellier A (1993)
Program and abstracts of the Ninth International Conference on AIDS
J. Tokars, R. Marcus, D. Culver, C. Schable, P. McKibben, C. Bandea, D. Bell (1993)
Surveillance of HIV Infection and Zidovudine Use among Health Care Workers after Occupational Exposure to HIV-Infected BloodAnnals of Internal Medicine, 118
Abstract In reply We appreciate the comments of Coutellier and colleagues, who point out that despite zidovudine therapy, human immunodeficiency virus (HIV) may still be transmitted to an exposed health care worker. This has happened on at least eight occasions,1-3 including the case cited by Coutellier et al.3 Anecdotal accounts of failures following the use of zidovudine for postexposure prophylaxis are of great concern, but provide only limited information on the efficacy of this approach. Without more rigorously collected data, it is difficult to draw any firm conclusions regarding the efficacy of zidovudine prophylaxis or the risk-benefit ratio of this therapy. More compelling are the results of two recent studies. A US Public Health Service study compared health care workers since 1988 in whom seroconversion occurred after percutaneous exposure to HIV-infected blood with similarly exposed health care workers in whom HIV infection did not develop.4 The preliminary findings References 1. Gerberding JL. Management of occupational exposures to blood-borne viruses. N Engl J Med . 1995;332:444-451.Crossref 2. Tokars JL, Marcus R, Culver DH, et al. Surveillance of HIV infection and zidovudine use among health care workers after occupational exposure to HIV-infected blood. Ann Intern Med . 1993;118:913-919.Crossref 3. Coutellier A, Desmoulins C, Veron M, Herson S. Failure of zidovudine prophylaxis after occupational needlestick injury. In: Program and abstracts of the Ninth International Conference on AIDS ; June 6-11, 1993; Berlin, Germany. Abstract B26-2074. 4. Cardo D, Srivastava P, Ciesielski C, et al. Case-control study of HIV seroconversion in health care workers after percutaneous exposure to HIV-infected blood. Presented at the 34th Interscience Conference on Antimicrobial Agents and Chemotherapy; October 4-7, 1994; Orlando, Fla. 5. Connor EM, Sperling RS, Gelber R, et al. Reduction of maternal-infant transmission of human immunodeficiency virus type 1 with zidovudine treatment. N Engl J Med . 1994;331:1173-1180.Crossref 6. Hirschel B, Kinloch S, Hoehn B, et al. Controlled trial of zidovudine in primary HIV infection. Presented at 34th Interscience Conference on Antimicrobial Agents and Chemotherapy; October 4-7, 1994; Orlando, Fla. 7. Erice A, Mayers DL, Strike DG, et al. Brief report: primary infection with zidovudine-resistant human immunodeficiency virus type 1. N Engl J Med . 1993;328:1163-1165.Crossref
Archives of Internal Medicine – American Medical Association
Published: Sep 11, 1995
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