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Is Nitroglycerin a Novel and Inexpensive Treatment for Osteoporosis?

Is Nitroglycerin a Novel and Inexpensive Treatment for Osteoporosis? Editorials represent the opinions EDITORIAL of the authors and JAMA and not those of the American Medical Association. Is Nitroglycerin a Novel and Inexpensive Treatment for Osteoporosis? sis, and in vitro mineralization by osteoblastic cells. The Sundeep Khosla, MD effects of nitric oxide on bone appear to be dose-dependent— high concentrations are detrimental to bone by enhancing URRENT FOOD AND DRUG ADMINISTRATION– osteoclastic bone resorption, inhibiting osteoblast prolif- approved medications in the United States for eration, and increasing osteoblast apoptosis. prevention or treatment of osteoporosis fall into At least part of the protective skeletal effect of estrogen C1 of 2 categories. The first includes antiresorptive appears to be mediated by the nitric oxide pathway. Con- drugs, which inhibit bone resorption, with a subsequent sistent with this, Wimalawansa et al demonstrated that der- reduction in coupled bone formation. These drugs increase mal application of nitroglycerin ointment was able to pre- bone mineral density (BMD), but this is due largely to vent ovariectomy-induced bone loss in rats. These refilling of bone remodeling cavities and an increase in investigators subsequently found that, as suggested by the mineralization density. There is no evidence that any of in vitro data indicating possible biphasic effects http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Is Nitroglycerin a Novel and Inexpensive Treatment for Osteoporosis?

JAMA , Volume 305 (8) – Feb 23, 2011

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Publisher
American Medical Association
Copyright
Copyright 2011 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.2011.191
pmid
21343584
Publisher site
See Article on Publisher Site

Abstract

Editorials represent the opinions EDITORIAL of the authors and JAMA and not those of the American Medical Association. Is Nitroglycerin a Novel and Inexpensive Treatment for Osteoporosis? sis, and in vitro mineralization by osteoblastic cells. The Sundeep Khosla, MD effects of nitric oxide on bone appear to be dose-dependent— high concentrations are detrimental to bone by enhancing URRENT FOOD AND DRUG ADMINISTRATION– osteoclastic bone resorption, inhibiting osteoblast prolif- approved medications in the United States for eration, and increasing osteoblast apoptosis. prevention or treatment of osteoporosis fall into At least part of the protective skeletal effect of estrogen C1 of 2 categories. The first includes antiresorptive appears to be mediated by the nitric oxide pathway. Con- drugs, which inhibit bone resorption, with a subsequent sistent with this, Wimalawansa et al demonstrated that der- reduction in coupled bone formation. These drugs increase mal application of nitroglycerin ointment was able to pre- bone mineral density (BMD), but this is due largely to vent ovariectomy-induced bone loss in rats. These refilling of bone remodeling cavities and an increase in investigators subsequently found that, as suggested by the mineralization density. There is no evidence that any of in vitro data indicating possible biphasic effects

Journal

JAMAAmerican Medical Association

Published: Feb 23, 2011

References