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Is Medical Therapy Effective for Regional Lymphadenitis Following BCG Vaccination?

Is Medical Therapy Effective for Regional Lymphadenitis Following BCG Vaccination? Abstract • We describe 120 patients with regional lymphadenitis following intradermal BCG vaccination. Seventy-eight of the patients were given medical therapy to prevent drainage and suppuration, and 42 patients were followed up without such treatment. The medical therapy group is divided into three subgroups: 36 were given erythromycin stearate, 21 isoniazid, and 21 isoniazid plus rifampin. No statistical difference in the incidence of spontaneous drainage and suppuration was found between the "no therapy" and the "medical therapy" groups. No significant superiority of any specific therapy was shown. If lymphadenitis develops rapidly (in two months), the incidence of spontaneous drainage and suppuration is significantly higher than in patients with slowly developing lesions. Total surgical excision is recommended to prevent spontaneous drainage and chronic suppuration in these rapidly evolving instances. (AJDC 1987;141:1213-1214) References 1. Ustevdt HJ: Usual and unusual reactions t[ill] BCG vaccination in children . Am Rev Respir Di[ill] 1956;74:32. 2. Viskum P, Jensen CM: Allergic, local and glandular response to BCG vaccination in the Danish mass tuberculosis campaign of 1950-1952. Acta Tuberc Scand 1955;31:326. 3. Hsing CT: Local complications of BCG vaccination in preschool children and newborn babies. Bull WHO 1954;11:1023. 4. Horwitz O, Meyer J: The safety record of BCG vaccination and untoward reactions observed after vaccination. Adv Tuberc Res 1957; 8:245. 5. Guld J, Magnus K, Magnusson M, et al: Suppurative lymphadenitis following intradermal BCG vaccination of the newborn. Br Med J 1955;2:1048-1054.Crossref 6. Stoppelman MRH, Drion EF: Complications of intracutaneous BCG vaccination in newborn infants . Acta Paediatr Scand 1958;47:65.Crossref 7. Vig-Nielsen I, et al: Suppurative lymphadenitis following intradermal BCG vaccination of preschool children . Bull WHO 1955;12:143. 8. Chaves-Carbello E, Sanchez GA: Regional lymphadenitis following BCG vaccination . Clin Pediatr 1972;11:693.Crossref 9. De Souza GR, Sant'Anna CC, Lapa e Silva JR, et al: Intradermal BCG vaccination complications: Analysis of 51 cases . Tubercle 1983; 64:23-27.Crossref 10. Power JT, Stewart IC, Ross JD: Erythromycin in the management of troublesome BCG lesions . Br J Dis Chest 1984;78:192-194.Crossref 11. Singh G, Singh M: Erythromycin for BCG cold abscess . Lancet 1984;2:979.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Is Medical Therapy Effective for Regional Lymphadenitis Following BCG Vaccination?

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Publisher
American Medical Association
Copyright
Copyright © 1987 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1987.04460110083029
Publisher site
See Article on Publisher Site

Abstract

Abstract • We describe 120 patients with regional lymphadenitis following intradermal BCG vaccination. Seventy-eight of the patients were given medical therapy to prevent drainage and suppuration, and 42 patients were followed up without such treatment. The medical therapy group is divided into three subgroups: 36 were given erythromycin stearate, 21 isoniazid, and 21 isoniazid plus rifampin. No statistical difference in the incidence of spontaneous drainage and suppuration was found between the "no therapy" and the "medical therapy" groups. No significant superiority of any specific therapy was shown. If lymphadenitis develops rapidly (in two months), the incidence of spontaneous drainage and suppuration is significantly higher than in patients with slowly developing lesions. Total surgical excision is recommended to prevent spontaneous drainage and chronic suppuration in these rapidly evolving instances. (AJDC 1987;141:1213-1214) References 1. Ustevdt HJ: Usual and unusual reactions t[ill] BCG vaccination in children . Am Rev Respir Di[ill] 1956;74:32. 2. Viskum P, Jensen CM: Allergic, local and glandular response to BCG vaccination in the Danish mass tuberculosis campaign of 1950-1952. Acta Tuberc Scand 1955;31:326. 3. Hsing CT: Local complications of BCG vaccination in preschool children and newborn babies. Bull WHO 1954;11:1023. 4. Horwitz O, Meyer J: The safety record of BCG vaccination and untoward reactions observed after vaccination. Adv Tuberc Res 1957; 8:245. 5. Guld J, Magnus K, Magnusson M, et al: Suppurative lymphadenitis following intradermal BCG vaccination of the newborn. Br Med J 1955;2:1048-1054.Crossref 6. Stoppelman MRH, Drion EF: Complications of intracutaneous BCG vaccination in newborn infants . Acta Paediatr Scand 1958;47:65.Crossref 7. Vig-Nielsen I, et al: Suppurative lymphadenitis following intradermal BCG vaccination of preschool children . Bull WHO 1955;12:143. 8. Chaves-Carbello E, Sanchez GA: Regional lymphadenitis following BCG vaccination . Clin Pediatr 1972;11:693.Crossref 9. De Souza GR, Sant'Anna CC, Lapa e Silva JR, et al: Intradermal BCG vaccination complications: Analysis of 51 cases . Tubercle 1983; 64:23-27.Crossref 10. Power JT, Stewart IC, Ross JD: Erythromycin in the management of troublesome BCG lesions . Br J Dis Chest 1984;78:192-194.Crossref 11. Singh G, Singh M: Erythromycin for BCG cold abscess . Lancet 1984;2:979.Crossref

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: Nov 1, 1987

References

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