Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Is Coffee Consumption a Contributor to Cardiovascular Disease?: Insights From the Framingham Study

Is Coffee Consumption a Contributor to Cardiovascular Disease?: Insights From the Framingham Study Abstract • Reported coffee consumption during 1954 to 1958 and 1971 to 1973 was used to test for association with cardiovascular disease (CVD) incidence and lipid values in the Framingham cohort. Multivariate analysis was employed, regressing CVD on age, systolic pressure, cigarette use, body mass index, total cholesterol, and coffee intake. In pooled analyses (2648 men with 549 CVD cases and 3566 women with 462 CVD cases) coffee intake was not associated with CVD incidence in either smokers or nonsmokers, irrespective of sex. Similarly, multivariate analyses for individuals with existing cardiovascular disease showed no association between coffee intake and subsequent cardiovascular disease. In men significant negative associations between coffee and total cholesterol, and very-low-density lipoprotein cholesterol were seen, whereas in women positive associations with low-density lipoprotein cholesterol were observed. Although inconsistent effects on the lipid profile were seen, no increase in primary or secondary CVD was seen with coffee drinking. (Arch Intern Med. 1989;149:1169-1172) References 1. Paul O, MacMillan A, McKean H, Park H. Sucrose intake and coronary heart disease . Lancet . 1968;2:1049-1051.Crossref 2. Boston Collaborative Drug Surveillance Group. Coffee drinking and acute myocardial infarction: report from the Boston Collaborative Drug Surveillance Program . Lancet . 1972;2:1278-1281. 3. Jick H, Miettinen OS, Neff RK, Shapiro S, Heinonen OP, Slone D. Coffee and myocardial infarction . N Engl J Med . 1973:289:63-67.Crossref 4. Dawber TR, Kannel WB, Gordon T. Coffee and cardiovascular disease: observations from the Framingham Study . N Engl J Med . 1974;291:871-874.Crossref 5. Klatsky AL, Friedman GD, Siegelaub AB. Coffee drinking prior to acute myocardial infarction: results from the Kaiser-Permanente epidemiologic study of myocardial infarction . JAMA . 1973;226:540-543.Crossref 6. Hrubec Z. Coffee drinking and ischaemic heart-disease . Lancet . 1973;1:548.Crossref 7. Hennekens CH, Drolette ME, Jesse MJ, Davies JE, Hutchinson GB. Coffee drinking and death due to coronary heart disease . N Engl J Med . 1976;294:633-636.Crossref 8. Yano K, Rhoads GG, Kagan A. Coffee, alcohol and risk of coronary heart disease among Japanese men living in Hawaii . N Engl J Med . 1977;294:405-409.Crossref 9. Rosenberg L, Slone D, Shapiro S, Kaufman DW, Stolley PD, Miettinen OS. Coffee drinking and myocardial infarction in young women . Am J Epidemiol . 1980;111:675-681. 10. Rosenberg L, Werler MW, Kaufman DW, Shapiro S. Coffee drinking and myocardial infarction in young women: an update . Am J Epidemiol . 1987;126:147-149. 11. Heyden S, Tyroler HA, Heiss G, Hames CG, Bartel A. Coffee consumption and mortality: total mortality, stroke mortality, and coronary heart disease mortality . Arch Intern Med . 1978;138:1472-1475.Crossref 12. Murray SS, Bjelke E, Gibson RW, Schuman LM. Coffee consumption and mortality from ischemic heart disease and other causes: results from the Lutheran Brotherhood Study, 1966-1978 . Am J Epidemiol . 1981;113:661-667. 13. Wilhelmsen L, Tibblin G, Elmfeldt D, Wedel H, Werko L. Coffee consumption and coronary heart disease in middle-aged Swedish men . Acta Med Scand . 1977;201:547-552.Crossref 14. Rosenberg L, Slone D, Shapiro S, Kaufman DW, Miettinen OS. Case-control studies on the acute effects of coffee upon the risk of myocardial infarction: problems in the selection of a hospital control series . Am J Epidemiol . 1981;113:646-652. 15. LaCroix AZ, Mead LA, Liang K-Y, Thomas CB, Pearson TA. Coffee consumption and the incidence of coronary heart disease . N Engl J Med . 1986;315:977-982.Crossref 16. Haffner SM, Knapp JA, Stern MP, Hazuda HP, Rosenthal M, Franco LJ. Coffee consumption, diet, and lipids . Am J Epidemiol . 1985;122:1-12. 17. Curb JD, Reed DM, Dautz JA, Yano K. Coffee, caffeine and serum cholesterol in Japanese men in Hawaii . Am J Epidemiol . 1986;123:648-655. 18. Mathias S, Garland C, Barrett-Connor E, Wingard DL. Coffee, plasma cholesterol, and lipoproteins: a population study in an adult community . Am J Epidemiol . 1985;121:896-905. 19. Williams PT, Wood PD, Vranizan KM, Albers JJ, Garay SC, Taylor CB. Coffee intake and elevated cholesterol and apolipoprotein B levels in men . JAMA . 1985;253:1407-1411.Crossref 20. Thelle DS, Arnesen E, Forde OH. The Tromso Heart Study: does coffee raise serum cholesterol? N Engl J Med . 1983;308:1454-1457.Crossref 21. Kark JD, Friedlander Y, Kaufman NA, Stein Y. Coffee, tea, and plasma cholesterol: the Jerusalem Lipid Research Clinic Prevalence Study . Br Med J . 1985;291:699-704.Crossref 22. Shirlow MJ, Mathers CD. Caffeine consumption and serum cholesterol levels . Int J Epidemiol . 1984;13:422-427.Crossref 23. Klatsky AL, Petitti DB, Armstrong MA, Friedman GD. Coffee, tea and cholesterol . Am J Cardiol . 1985;55:577-578.Crossref 24. Hofman A, Van Laar A, Klein F, Valkenburg HA. Coffee and cholesterol . N Engl J Med . 1983;309:1248-1249.Crossref 25. Shekelle RG, Gale M, Paul O, Stamler J. Coffee and cholesterol . N Engl J Med . 1983;309:1249. 26. Phillips NR, Havel RJ, Kane JP. Levels and interrelationships of serum and lipoprotein cholesterol and triglycerides . Arteriosclerosis . 1981;1:13-24.Crossref 27. Kovar MG, Fulwood F, Feinleib M. Coffee and cholesterol . N Engl J Med . 1983;309:1249. 28. Heyden S, Heiss G, Manegold C, et al. The combined effect of smoking and coffee drinking on LDL and HDL cholesterol . Circulation . 1979;60:22-25.Crossref 29. Forde OH, Knutsen SF, Arnesen E, Thelle DS. The Tromso Heart Study: coffee consumption and serum lipid concentrations in men with hypercholesterolaemia: a randomised intervention study . Br Med J . 1985;290:893-895.Crossref 30. Donahue RP, Orchard TJ, Stein EA, Kuller LH. Lack of an association between coffee consumption and lipoprotein lipids and apolipoproteins in young adults: the Beaver County Study . Prev Med . 1987;16:796-802.Crossref 31. Abell LL, Levy BB, Brodie BB, KendallFE. A simplified method for the estimation of total cholesterol in serum and demonstration of its specificity . J Biol Chem . 1952;195:357-366. 32. Manual of Laboratory Operation, Lipid Research Clinics Program; 1974:1. US Dept of Health, Education, and Welfare publication NIH 54-628. 33. Shurtleff D. Some characteristics related to the incidence of cardiovascular disease and death. Framingham Study, 18-year follow-up; 1974. US Dept of Health, Education, and Welfare publication NIH 74-599. 34. Wu M, Ware JH. On the use of repeated measurements in regression analysis with dichotomous response . Biometrics . 1979;35:513-521.Crossref 35. Cox DR. Regression models and life tables (with discussion) . J R Stat Soc . 1972;34:187-220. 36. Harrel FE, Lee KL. Verifying assumptions of the Cox proportional hazards model. In: Proceedings of the 11th Annual SAS User's Group International Conference. Cary, NC: SAS Institute; 1986. 37. Prineas RJ, Jacobs DR Jr, Crow RS, Blackburn H. Coffee, tea, and VPB . J Chronic Dis . 1980;33:67-72.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Is Coffee Consumption a Contributor to Cardiovascular Disease?: Insights From the Framingham Study

Loading next page...
 
/lp/american-medical-association/is-coffee-consumption-a-contributor-to-cardiovascular-disease-insights-d6Pw6Wp5pn
Publisher
American Medical Association
Copyright
Copyright © 1989 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1989.00390050125025
Publisher site
See Article on Publisher Site

Abstract

Abstract • Reported coffee consumption during 1954 to 1958 and 1971 to 1973 was used to test for association with cardiovascular disease (CVD) incidence and lipid values in the Framingham cohort. Multivariate analysis was employed, regressing CVD on age, systolic pressure, cigarette use, body mass index, total cholesterol, and coffee intake. In pooled analyses (2648 men with 549 CVD cases and 3566 women with 462 CVD cases) coffee intake was not associated with CVD incidence in either smokers or nonsmokers, irrespective of sex. Similarly, multivariate analyses for individuals with existing cardiovascular disease showed no association between coffee intake and subsequent cardiovascular disease. In men significant negative associations between coffee and total cholesterol, and very-low-density lipoprotein cholesterol were seen, whereas in women positive associations with low-density lipoprotein cholesterol were observed. Although inconsistent effects on the lipid profile were seen, no increase in primary or secondary CVD was seen with coffee drinking. (Arch Intern Med. 1989;149:1169-1172) References 1. Paul O, MacMillan A, McKean H, Park H. Sucrose intake and coronary heart disease . Lancet . 1968;2:1049-1051.Crossref 2. Boston Collaborative Drug Surveillance Group. Coffee drinking and acute myocardial infarction: report from the Boston Collaborative Drug Surveillance Program . Lancet . 1972;2:1278-1281. 3. Jick H, Miettinen OS, Neff RK, Shapiro S, Heinonen OP, Slone D. Coffee and myocardial infarction . N Engl J Med . 1973:289:63-67.Crossref 4. Dawber TR, Kannel WB, Gordon T. Coffee and cardiovascular disease: observations from the Framingham Study . N Engl J Med . 1974;291:871-874.Crossref 5. Klatsky AL, Friedman GD, Siegelaub AB. Coffee drinking prior to acute myocardial infarction: results from the Kaiser-Permanente epidemiologic study of myocardial infarction . JAMA . 1973;226:540-543.Crossref 6. Hrubec Z. Coffee drinking and ischaemic heart-disease . Lancet . 1973;1:548.Crossref 7. Hennekens CH, Drolette ME, Jesse MJ, Davies JE, Hutchinson GB. Coffee drinking and death due to coronary heart disease . N Engl J Med . 1976;294:633-636.Crossref 8. Yano K, Rhoads GG, Kagan A. Coffee, alcohol and risk of coronary heart disease among Japanese men living in Hawaii . N Engl J Med . 1977;294:405-409.Crossref 9. Rosenberg L, Slone D, Shapiro S, Kaufman DW, Stolley PD, Miettinen OS. Coffee drinking and myocardial infarction in young women . Am J Epidemiol . 1980;111:675-681. 10. Rosenberg L, Werler MW, Kaufman DW, Shapiro S. Coffee drinking and myocardial infarction in young women: an update . Am J Epidemiol . 1987;126:147-149. 11. Heyden S, Tyroler HA, Heiss G, Hames CG, Bartel A. Coffee consumption and mortality: total mortality, stroke mortality, and coronary heart disease mortality . Arch Intern Med . 1978;138:1472-1475.Crossref 12. Murray SS, Bjelke E, Gibson RW, Schuman LM. Coffee consumption and mortality from ischemic heart disease and other causes: results from the Lutheran Brotherhood Study, 1966-1978 . Am J Epidemiol . 1981;113:661-667. 13. Wilhelmsen L, Tibblin G, Elmfeldt D, Wedel H, Werko L. Coffee consumption and coronary heart disease in middle-aged Swedish men . Acta Med Scand . 1977;201:547-552.Crossref 14. Rosenberg L, Slone D, Shapiro S, Kaufman DW, Miettinen OS. Case-control studies on the acute effects of coffee upon the risk of myocardial infarction: problems in the selection of a hospital control series . Am J Epidemiol . 1981;113:646-652. 15. LaCroix AZ, Mead LA, Liang K-Y, Thomas CB, Pearson TA. Coffee consumption and the incidence of coronary heart disease . N Engl J Med . 1986;315:977-982.Crossref 16. Haffner SM, Knapp JA, Stern MP, Hazuda HP, Rosenthal M, Franco LJ. Coffee consumption, diet, and lipids . Am J Epidemiol . 1985;122:1-12. 17. Curb JD, Reed DM, Dautz JA, Yano K. Coffee, caffeine and serum cholesterol in Japanese men in Hawaii . Am J Epidemiol . 1986;123:648-655. 18. Mathias S, Garland C, Barrett-Connor E, Wingard DL. Coffee, plasma cholesterol, and lipoproteins: a population study in an adult community . Am J Epidemiol . 1985;121:896-905. 19. Williams PT, Wood PD, Vranizan KM, Albers JJ, Garay SC, Taylor CB. Coffee intake and elevated cholesterol and apolipoprotein B levels in men . JAMA . 1985;253:1407-1411.Crossref 20. Thelle DS, Arnesen E, Forde OH. The Tromso Heart Study: does coffee raise serum cholesterol? N Engl J Med . 1983;308:1454-1457.Crossref 21. Kark JD, Friedlander Y, Kaufman NA, Stein Y. Coffee, tea, and plasma cholesterol: the Jerusalem Lipid Research Clinic Prevalence Study . Br Med J . 1985;291:699-704.Crossref 22. Shirlow MJ, Mathers CD. Caffeine consumption and serum cholesterol levels . Int J Epidemiol . 1984;13:422-427.Crossref 23. Klatsky AL, Petitti DB, Armstrong MA, Friedman GD. Coffee, tea and cholesterol . Am J Cardiol . 1985;55:577-578.Crossref 24. Hofman A, Van Laar A, Klein F, Valkenburg HA. Coffee and cholesterol . N Engl J Med . 1983;309:1248-1249.Crossref 25. Shekelle RG, Gale M, Paul O, Stamler J. Coffee and cholesterol . N Engl J Med . 1983;309:1249. 26. Phillips NR, Havel RJ, Kane JP. Levels and interrelationships of serum and lipoprotein cholesterol and triglycerides . Arteriosclerosis . 1981;1:13-24.Crossref 27. Kovar MG, Fulwood F, Feinleib M. Coffee and cholesterol . N Engl J Med . 1983;309:1249. 28. Heyden S, Heiss G, Manegold C, et al. The combined effect of smoking and coffee drinking on LDL and HDL cholesterol . Circulation . 1979;60:22-25.Crossref 29. Forde OH, Knutsen SF, Arnesen E, Thelle DS. The Tromso Heart Study: coffee consumption and serum lipid concentrations in men with hypercholesterolaemia: a randomised intervention study . Br Med J . 1985;290:893-895.Crossref 30. Donahue RP, Orchard TJ, Stein EA, Kuller LH. Lack of an association between coffee consumption and lipoprotein lipids and apolipoproteins in young adults: the Beaver County Study . Prev Med . 1987;16:796-802.Crossref 31. Abell LL, Levy BB, Brodie BB, KendallFE. A simplified method for the estimation of total cholesterol in serum and demonstration of its specificity . J Biol Chem . 1952;195:357-366. 32. Manual of Laboratory Operation, Lipid Research Clinics Program; 1974:1. US Dept of Health, Education, and Welfare publication NIH 54-628. 33. Shurtleff D. Some characteristics related to the incidence of cardiovascular disease and death. Framingham Study, 18-year follow-up; 1974. US Dept of Health, Education, and Welfare publication NIH 74-599. 34. Wu M, Ware JH. On the use of repeated measurements in regression analysis with dichotomous response . Biometrics . 1979;35:513-521.Crossref 35. Cox DR. Regression models and life tables (with discussion) . J R Stat Soc . 1972;34:187-220. 36. Harrel FE, Lee KL. Verifying assumptions of the Cox proportional hazards model. In: Proceedings of the 11th Annual SAS User's Group International Conference. Cary, NC: SAS Institute; 1986. 37. Prineas RJ, Jacobs DR Jr, Crow RS, Blackburn H. Coffee, tea, and VPB . J Chronic Dis . 1980;33:67-72.Crossref

Journal

Archives of Internal MedicineAmerican Medical Association

Published: May 1, 1989

References