Abstract • We studied the effect of "irritants" on the response to an allergen in 15 patients. Dilutions of allergens were applied in duplicate, and 24 hours later they were removed and sodium lauryl sulfate (11 subjects) or anthralin (dithranol) (four subjects) was applied for a further 24 hours to one set of patches. Control dilutions of irritants alone were applied. Responses were measured objectively at 72 hours. The response to both allergen and irritant was greater than to either alone. Doses of allergen, which did not produce a response when applied alone, produced a response when an irritant was added. Irritants therefore increase the allergic contact dermatitis response and may explain the presence of contact dermatitis in patients with negative patch tests. (Arch Dermatol. 1991;127:1016-1019) References 1. McLelland J, Shuster S. Contact dermatitis with negative patch tests: the additive effect of allergens in combination . Br J Dermatol. 1990;122:623-630.Crossref 2. Van der Valk PGM, Nater JP, Blovmink E. Skin irritancy of surfactants as measured by water vapor loss measurements . J Invest Dermatol. 1984;82:291-293.Crossref 3. Lawrence CM, Shuster S. Mechanism of anthralin inflammation, I: dissociation of response to clobetasol and indomethacin . Br J Dermatol. 1985;113:107-115.Crossref 4. Friedmann PS, Moss C, Shuster S, Simpson JM. Quantitative relationships between sensitising dose of DNCB and reactivity in normal subjects . Clin Exp Immunol. 1983;53:709-715. 5. Lawrence CM, Howel D, Shuster S. The inflammatory response to anthralin . Clin Exp Dermatol. 1984;9:336-341.Crossref 6. Wilkinson DS, Fregert S, Magnusson B, et al. Terminology of contact dermatitis . Acta Derm Venereol (Stockh). 1970;50:287-292. 7. Garioch J, Biagioni P, Forsyth A, Baillie A, MacPherson D. Infrared thermography of the allergic response to nickel . Br J Dermatol. 1989;121:41.Crossref 8. Sonnex TS, Ryan TJ. An investigation of the angry back syndrome using Trufuril . Br J Dermatol. 1987;116:361-370.Crossref 9. Moss C, Friedmann PS, Shuster S, Simpson JM. Susceptibility and amplification of sensitivity in contact dermatitis . Clin Exp Immunol. 1985;61:232-241.
Archives of Dermatology – American Medical Association
Published: Jul 1, 1991