Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You and Your Team.

Learn More →

Iron Metabolism in Skin Disease

Iron Metabolism in Skin Disease Abstract Serum iron concentration and total iron binding capacity have been measured in 100 patients with different dermatoses. Serum iron concentration has been found to be reduced in a number of these patients and this hypoferremia has often been associated with a normal or decreased iron binding capacity. This defect of iron metabolism has been studied further in some of the patients in whom its absorption, iron loss from the skin and bowel, disappearance of59Fe from the plasma, and incorporation of59Fe into the erythrocytes have been measured. Some patients with skin disease are truly iron deficient as a result of excessive loss of iron in scales or as a result of malabsorption, but in the majority of cases the hypoferremia of skin disease is due to a metabolic abnormality of iron metabolism similar to that which occurs in infection. References 1. Gunther, R.T.: The Greek Herbal of Dioscorides , New York: Hafner Publishing Co., 1959, p 631. 2. Dubach, R.; Callender, S.T.; and Moore, C.V.: Studies in Iron Transportation and Metabolism: VI. Absorption of Radioactive Iron in Patients With Fever and With Anaemias of Varied Aetiology , Blood 3:526-540 ( (May) ) 1948. 3. Shuster, S., and Marks, J.: Dermatogenic Enteropathy: A New Cause of Steatorrhoea , Lancet 1:1367-1368 ( (June 26) ) 1965.Crossref 4. Van de Kramer, J.H.; Bokkel Huininck, H. ten.; and Weyers, H.A.: Rapid Method for the Determination of Fat in Faeces , J Biol Chem 177:347-355 ( (Jan) ) 1949. 5. Bothwell, T.H., and Finch, C.A.: Iron Metabolism , London: J. & A. Churchill, Ltd., 1964, p 121. 6. Loeffler, R.K.; Rappoport, D.A.; and Collins, V.P.: Radio-Iron Citrate as a Tracer to Determine Disappearance Rate of Plasma Iron in Normal Subjects , Proc Soc Exp Biol Med 88:441-444 ( (March) ) 1955.Crossref 7. Bothwell, T.H., et al: Erythrokinetics: IV. The Plasma Iron Turnover as a Measure of Erythropoieses , Blood 12:409 ( (May) ) 1957. 8. Hart, D., and Metz, J.: The Estimation of Red Cell Volume With 51 Cr Labelled Erythrocytes and Plasma Volume With Radio-Iodinated Human Serum Albumin , J Clin Path 15:459-461 ( (Sept) ) 1962.Crossref 9. Huff, R.L., et al: Ferrokinetics in Normal Persons and in Patients Having Various Erythropoietic Disorders , J Clin Invest 30:1512-1526, 1951.Crossref 10. Moore, C.V.: " Iron Nutrition " in Iron Metabolism , F. Gross (ed.) New York: Springer-Verlag, 1964, p 241. 11. Shuster, S.: Systemic Effects of Skin Disease , Lancet 1:907-912 ( (April 29) ) 1967.Crossref 12. Shuster, S.; Marks, J.; and Chanarin, I.: Folic Glycine-C14 Incorporation Into the Proteins of Normal Stratum Corneum and the Abnormal Stratum Corneum of Psoriasis , J Invest Derm 37:497-504 ( (July 1) ) 1961.Crossref 13. Cartwright, G.E., and Wintrobe, N.N.: Chemical, Clinical and Immunological Studies on the Products of Human Plasma Fractionation: XXXIX. The Anaemia of Infection; Studies on the Iron-binding Capacity of Serum , J Clin Invest 28:86-98, 1949.Crossref 14. Shuster, S., and Wilkinson, P.: Protein Metabolism in Exfoliative Dermatitis and Erythroderma , Brit J Derm 75:344-353 ( (Aug) -Sept) 1963.Crossref 15. Marks, J., and Shuster, S.: Method for Measuring Capillary Permeability and Its Use in Patients With Skin Disease , Brit Med J 2:88-90 ( (July 9) ) 1966.Crossref 16. Bothwell, J.H., et al: The Study of Erythropoiesis Using Tracer Quantities of Radioactive Iron , Brit J Haemat 2:1-16 ( (Jan) ) 1956.Crossref 17. Bothwell, T.H., and Finch, C.A.: Iron Metabolism London: J & A Churchill, Ltd., 1964, p 210. 18. Shuster, S., and Marks, J.: Dermatopathic Anaemia , Brit J Derm 79:393-397 ( (July) ) 1967.Crossref 19. Shuster, S.; Marks, J.; and Chanarin, I.: Folic Acid Metabolism in Patients With Skin Disease , Brit J Derm 79:398-402 ( (July) ) 1967.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Iron Metabolism in Skin Disease

Marks, Janet; Shuster, Sam
Archives of Dermatology , Volume 98 (5) – Nov 1, 1968
Download PDF
7 pages
Read Article

Loading next page...
 
/lp/american-medical-association/iron-metabolism-in-skin-disease-Z0YcNjT5XL
Publisher
American Medical Association
Copyright
Copyright © 1968 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1968.01610170029003
Publisher site
See Article on Publisher Site

Abstract

Abstract Serum iron concentration and total iron binding capacity have been measured in 100 patients with different dermatoses. Serum iron concentration has been found to be reduced in a number of these patients and this hypoferremia has often been associated with a normal or decreased iron binding capacity. This defect of iron metabolism has been studied further in some of the patients in whom its absorption, iron loss from the skin and bowel, disappearance of59Fe from the plasma, and incorporation of59Fe into the erythrocytes have been measured. Some patients with skin disease are truly iron deficient as a result of excessive loss of iron in scales or as a result of malabsorption, but in the majority of cases the hypoferremia of skin disease is due to a metabolic abnormality of iron metabolism similar to that which occurs in infection. References 1. Gunther, R.T.: The Greek Herbal of Dioscorides , New York: Hafner Publishing Co., 1959, p 631. 2. Dubach, R.; Callender, S.T.; and Moore, C.V.: Studies in Iron Transportation and Metabolism: VI. Absorption of Radioactive Iron in Patients With Fever and With Anaemias of Varied Aetiology , Blood 3:526-540 ( (May) ) 1948. 3. Shuster, S., and Marks, J.: Dermatogenic Enteropathy: A New Cause of Steatorrhoea , Lancet 1:1367-1368 ( (June 26) ) 1965.Crossref 4. Van de Kramer, J.H.; Bokkel Huininck, H. ten.; and Weyers, H.A.: Rapid Method for the Determination of Fat in Faeces , J Biol Chem 177:347-355 ( (Jan) ) 1949. 5. Bothwell, T.H., and Finch, C.A.: Iron Metabolism , London: J. & A. Churchill, Ltd., 1964, p 121. 6. Loeffler, R.K.; Rappoport, D.A.; and Collins, V.P.: Radio-Iron Citrate as a Tracer to Determine Disappearance Rate of Plasma Iron in Normal Subjects , Proc Soc Exp Biol Med 88:441-444 ( (March) ) 1955.Crossref 7. Bothwell, T.H., et al: Erythrokinetics: IV. The Plasma Iron Turnover as a Measure of Erythropoieses , Blood 12:409 ( (May) ) 1957. 8. Hart, D., and Metz, J.: The Estimation of Red Cell Volume With 51 Cr Labelled Erythrocytes and Plasma Volume With Radio-Iodinated Human Serum Albumin , J Clin Path 15:459-461 ( (Sept) ) 1962.Crossref 9. Huff, R.L., et al: Ferrokinetics in Normal Persons and in Patients Having Various Erythropoietic Disorders , J Clin Invest 30:1512-1526, 1951.Crossref 10. Moore, C.V.: " Iron Nutrition " in Iron Metabolism , F. Gross (ed.) New York: Springer-Verlag, 1964, p 241. 11. Shuster, S.: Systemic Effects of Skin Disease , Lancet 1:907-912 ( (April 29) ) 1967.Crossref 12. Shuster, S.; Marks, J.; and Chanarin, I.: Folic Glycine-C14 Incorporation Into the Proteins of Normal Stratum Corneum and the Abnormal Stratum Corneum of Psoriasis , J Invest Derm 37:497-504 ( (July 1) ) 1961.Crossref 13. Cartwright, G.E., and Wintrobe, N.N.: Chemical, Clinical and Immunological Studies on the Products of Human Plasma Fractionation: XXXIX. The Anaemia of Infection; Studies on the Iron-binding Capacity of Serum , J Clin Invest 28:86-98, 1949.Crossref 14. Shuster, S., and Wilkinson, P.: Protein Metabolism in Exfoliative Dermatitis and Erythroderma , Brit J Derm 75:344-353 ( (Aug) -Sept) 1963.Crossref 15. Marks, J., and Shuster, S.: Method for Measuring Capillary Permeability and Its Use in Patients With Skin Disease , Brit Med J 2:88-90 ( (July 9) ) 1966.Crossref 16. Bothwell, J.H., et al: The Study of Erythropoiesis Using Tracer Quantities of Radioactive Iron , Brit J Haemat 2:1-16 ( (Jan) ) 1956.Crossref 17. Bothwell, T.H., and Finch, C.A.: Iron Metabolism London: J & A Churchill, Ltd., 1964, p 210. 18. Shuster, S., and Marks, J.: Dermatopathic Anaemia , Brit J Derm 79:393-397 ( (July) ) 1967.Crossref 19. Shuster, S.; Marks, J.; and Chanarin, I.: Folic Acid Metabolism in Patients With Skin Disease , Brit J Derm 79:398-402 ( (July) ) 1967.Crossref

Journal

Archives of Dermatology – American Medical Association

Published: Nov 1, 1968

References

  • The Greek Herbal of Dioscorides
    Gunther , R.T.
  • Studies in Iron Transportation and Metabolism: VI. Absorption of Radioactive Iron in Patients With Fever and With Anaemias of Varied Aetiology
    Dubach , R.; Callender, S.T.; and Moore, C.V.
  • Dermatogenic Enteropathy: A New Cause of Steatorrhoea
    Shuster , S., and Marks, J.
  • Rapid Method for the Determination of Fat in Faeces
    Van de Kramer , J.H.; Bokkel Huininck, H. ten.; and Weyers, H.A.
  • Iron Metabolism
    Bothwell , T.H., and Finch, C.A.
  • Radio-Iron Citrate as a Tracer to Determine Disappearance Rate of Plasma Iron in Normal Subjects
    Loeffler , R.K.; Rappoport, D.A.; and Collins, V.P.
  • Erythrokinetics: IV. The Plasma Iron Turnover as a Measure of Erythropoieses
    Bothwell , T.H., et al
  • The Estimation of Red Cell Volume With 51 Cr Labelled Erythrocytes and Plasma Volume With Radio-Iodinated Human Serum Albumin
    Hart , D., and Metz, J.
  • Ferrokinetics in Normal Persons and in Patients Having Various Erythropoietic Disorders
    Huff , R.L., et al
  • Iron Metabolism
    Moore , C.V.: "
  • Systemic Effects of Skin Disease
    Shuster , S.
  • Folic Glycine-C14 Incorporation Into the Proteins of Normal Stratum Corneum and the Abnormal Stratum Corneum of Psoriasis
    Shuster , S.; Marks, J.; and Chanarin, I.
  • Chemical, Clinical and Immunological Studies on the Products of Human Plasma Fractionation: XXXIX. The Anaemia of Infection
    Cartwright , G.E., and Wintrobe, N.N.
  • Protein Metabolism in Exfoliative Dermatitis and Erythroderma
    Shuster , S., and Wilkinson, P.
  • Method for Measuring Capillary Permeability and Its Use in Patients With Skin Disease
    Marks , J., and Shuster, S.
  • The Study of Erythropoiesis Using Tracer Quantities of Radioactive Iron
    Bothwell , J.H., et al
  • Iron Metabolism
    Bothwell , T.H., and Finch, C.A.
  • Dermatopathic Anaemia
    Shuster , S., and Marks, J.
  • Folic Acid Metabolism in Patients With Skin Disease
    Shuster , S.; Marks, J.; and Chanarin, I.

You’re reading a free preview. Subscribe to read the entire article.

Try 2 weeks free now

DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

or browse the journals available

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$499/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

Sign up
for free
Start 14 day
Free Trial