Abstract Serum iron concentration and total iron binding capacity have been measured in 100 patients with different dermatoses. Serum iron concentration has been found to be reduced in a number of these patients and this hypoferremia has often been associated with a normal or decreased iron binding capacity. This defect of iron metabolism has been studied further in some of the patients in whom its absorption, iron loss from the skin and bowel, disappearance of59Fe from the plasma, and incorporation of59Fe into the erythrocytes have been measured. Some patients with skin disease are truly iron deficient as a result of excessive loss of iron in scales or as a result of malabsorption, but in the majority of cases the hypoferremia of skin disease is due to a metabolic abnormality of iron metabolism similar to that which occurs in infection. References 1. Gunther, R.T.: The Greek Herbal of Dioscorides , New York: Hafner Publishing Co., 1959, p 631. 2. Dubach, R.; Callender, S.T.; and Moore, C.V.: Studies in Iron Transportation and Metabolism: VI. Absorption of Radioactive Iron in Patients With Fever and With Anaemias of Varied Aetiology , Blood 3:526-540 ( (May) ) 1948. 3. Shuster, S., and Marks, J.: Dermatogenic Enteropathy: A New Cause of Steatorrhoea , Lancet 1:1367-1368 ( (June 26) ) 1965.Crossref 4. Van de Kramer, J.H.; Bokkel Huininck, H. ten.; and Weyers, H.A.: Rapid Method for the Determination of Fat in Faeces , J Biol Chem 177:347-355 ( (Jan) ) 1949. 5. Bothwell, T.H., and Finch, C.A.: Iron Metabolism , London: J. & A. Churchill, Ltd., 1964, p 121. 6. Loeffler, R.K.; Rappoport, D.A.; and Collins, V.P.: Radio-Iron Citrate as a Tracer to Determine Disappearance Rate of Plasma Iron in Normal Subjects , Proc Soc Exp Biol Med 88:441-444 ( (March) ) 1955.Crossref 7. Bothwell, T.H., et al: Erythrokinetics: IV. The Plasma Iron Turnover as a Measure of Erythropoieses , Blood 12:409 ( (May) ) 1957. 8. Hart, D., and Metz, J.: The Estimation of Red Cell Volume With 51 Cr Labelled Erythrocytes and Plasma Volume With Radio-Iodinated Human Serum Albumin , J Clin Path 15:459-461 ( (Sept) ) 1962.Crossref 9. Huff, R.L., et al: Ferrokinetics in Normal Persons and in Patients Having Various Erythropoietic Disorders , J Clin Invest 30:1512-1526, 1951.Crossref 10. Moore, C.V.: " Iron Nutrition " in Iron Metabolism , F. Gross (ed.) New York: Springer-Verlag, 1964, p 241. 11. Shuster, S.: Systemic Effects of Skin Disease , Lancet 1:907-912 ( (April 29) ) 1967.Crossref 12. Shuster, S.; Marks, J.; and Chanarin, I.: Folic Glycine-C14 Incorporation Into the Proteins of Normal Stratum Corneum and the Abnormal Stratum Corneum of Psoriasis , J Invest Derm 37:497-504 ( (July 1) ) 1961.Crossref 13. Cartwright, G.E., and Wintrobe, N.N.: Chemical, Clinical and Immunological Studies on the Products of Human Plasma Fractionation: XXXIX. The Anaemia of Infection; Studies on the Iron-binding Capacity of Serum , J Clin Invest 28:86-98, 1949.Crossref 14. Shuster, S., and Wilkinson, P.: Protein Metabolism in Exfoliative Dermatitis and Erythroderma , Brit J Derm 75:344-353 ( (Aug) -Sept) 1963.Crossref 15. Marks, J., and Shuster, S.: Method for Measuring Capillary Permeability and Its Use in Patients With Skin Disease , Brit Med J 2:88-90 ( (July 9) ) 1966.Crossref 16. Bothwell, J.H., et al: The Study of Erythropoiesis Using Tracer Quantities of Radioactive Iron , Brit J Haemat 2:1-16 ( (Jan) ) 1956.Crossref 17. Bothwell, T.H., and Finch, C.A.: Iron Metabolism London: J & A Churchill, Ltd., 1964, p 210. 18. Shuster, S., and Marks, J.: Dermatopathic Anaemia , Brit J Derm 79:393-397 ( (July) ) 1967.Crossref 19. Shuster, S.; Marks, J.; and Chanarin, I.: Folic Acid Metabolism in Patients With Skin Disease , Brit J Derm 79:398-402 ( (July) ) 1967.Crossref
Archives of Dermatology – American Medical Association
Published: Nov 1, 1968
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