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Iron in Infancy and Long-term Development

Iron in Infancy and Long-term Development EDITORIAL ONLINE FIRST N THIS ISSUE OF THE ARCHIVES,LOZOFF ET AL though longitudinal, these studies have not allowed for mak- report the findings of a long-term follow-up of ing causal inferences. When examined with respect to re- children at 10 years of age who were partici- sponse to treatment, studies in infants and young children pants in a double-masked, randomized con- have yielded mixed results. In short-term studies of treat- I trolled trial conducted from 1991 through 1994 ment with iron in deficient infants, 2 studies showed an 8,9 in Santiago, Chile, testing iron-fortified (12.7 mg/L) vs improvement in a subset of scales, while 2 others found 10,11 low-iron (2.3 mg/L) infant formula use from 6 to 12 no improvement in any measured scale. months of age. All infants enrolled in the original trial With regard to prevention, there are few randomized were screened to have no iron deficiency anemia at the supplementation trials of iron among infants examining outset. Among 57% of the original sample of children who short-term cognitive and motor outcomes. Some have were reached, an intent-to-treat analysis showed that the shown positive effects on varying aspects of infants’ be- mean scores on tests of spatial http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Pediatrics American Medical Association

Iron in Infancy and Long-term Development

JAMA Pediatrics , Volume 166 (3) – Mar 1, 2012

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References (21)

Publisher
American Medical Association
Copyright
Copyright 2012 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-6203
eISSN
2168-6211
DOI
10.1001/archpediatrics.2011.203
pmid
22064873
Publisher site
See Article on Publisher Site

Abstract

EDITORIAL ONLINE FIRST N THIS ISSUE OF THE ARCHIVES,LOZOFF ET AL though longitudinal, these studies have not allowed for mak- report the findings of a long-term follow-up of ing causal inferences. When examined with respect to re- children at 10 years of age who were partici- sponse to treatment, studies in infants and young children pants in a double-masked, randomized con- have yielded mixed results. In short-term studies of treat- I trolled trial conducted from 1991 through 1994 ment with iron in deficient infants, 2 studies showed an 8,9 in Santiago, Chile, testing iron-fortified (12.7 mg/L) vs improvement in a subset of scales, while 2 others found 10,11 low-iron (2.3 mg/L) infant formula use from 6 to 12 no improvement in any measured scale. months of age. All infants enrolled in the original trial With regard to prevention, there are few randomized were screened to have no iron deficiency anemia at the supplementation trials of iron among infants examining outset. Among 57% of the original sample of children who short-term cognitive and motor outcomes. Some have were reached, an intent-to-treat analysis showed that the shown positive effects on varying aspects of infants’ be- mean scores on tests of spatial

Journal

JAMA PediatricsAmerican Medical Association

Published: Mar 1, 2012

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