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Iodine Poisoning Secondary to Long-term Iodinated Glycerol Therapy

Iodine Poisoning Secondary to Long-term Iodinated Glycerol Therapy Abstract Iodinated glycerol is used as a mucolytic agent in the treatment of chronic obstructive pulmonary disease. Its efficacy is controversial, and reports of its toxicity are substantial. We report a case of chronic iodine poisoning in a patient with chronic obstructive pulmonary disease following 20 years of iodinated glycerol therapy. Reevaluation of the long-term use of this medication is encouraged. Monitoring long-term recipients of iodinated glycerol therapy for chronic iodine poisoning and drug-induced thyroid abnormalities is recommended. (Arch Intern Med. 1994;154:1153-1156) References 1. Petty TL. The National Mucolytic Study: results of a double-blind, placebocontrolled study of iodinated glycerol in chronic bronchitis . Chest . 1990;97: 75-83.Crossref 2. Ferguson GT, Cherniak RM. Management of chronic obstructive pulmonary disease . N Engl J Med . 1993;328:1017-1022.Crossref 3. Drinka PJ, Nolten WE. Effects of iodinated glycerol on thyroid function studies in elderly nursing home residents . J Am Geriatr Soc . 1988;36:911-913. 4. Gomolin IH. Iodinated glycerol-induced hypothyroidism . Drug Intell Clin Pharm . 1987;21:726-727. 5. Huseby JS, Bennett SW, Hagensee ME. Hyperthyroidism induced by iodinated glycerol . Am Rev Respir Dis . 1991;144:1403.Crossref 6. Block SH. Goiter complicating therapy with iodinated glycerol (Organidin) . J Pediatr . 1973;83:84-86.Crossref 7. Olin BR, ed. Drug Facts and Comparisons . St Louis, Mo: JB Lippincott Co; 1991:198. 8. McEvoy GK, ed. American Hospital Formulary Service Drug Information . Bethesda, Md: American Society of Hospital Pharmacists Inc; 1992:1603. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Iodine Poisoning Secondary to Long-term Iodinated Glycerol Therapy

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Publisher
American Medical Association
Copyright
Copyright © 1994 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1994.00420100140018
Publisher site
See Article on Publisher Site

Abstract

Abstract Iodinated glycerol is used as a mucolytic agent in the treatment of chronic obstructive pulmonary disease. Its efficacy is controversial, and reports of its toxicity are substantial. We report a case of chronic iodine poisoning in a patient with chronic obstructive pulmonary disease following 20 years of iodinated glycerol therapy. Reevaluation of the long-term use of this medication is encouraged. Monitoring long-term recipients of iodinated glycerol therapy for chronic iodine poisoning and drug-induced thyroid abnormalities is recommended. (Arch Intern Med. 1994;154:1153-1156) References 1. Petty TL. The National Mucolytic Study: results of a double-blind, placebocontrolled study of iodinated glycerol in chronic bronchitis . Chest . 1990;97: 75-83.Crossref 2. Ferguson GT, Cherniak RM. Management of chronic obstructive pulmonary disease . N Engl J Med . 1993;328:1017-1022.Crossref 3. Drinka PJ, Nolten WE. Effects of iodinated glycerol on thyroid function studies in elderly nursing home residents . J Am Geriatr Soc . 1988;36:911-913. 4. Gomolin IH. Iodinated glycerol-induced hypothyroidism . Drug Intell Clin Pharm . 1987;21:726-727. 5. Huseby JS, Bennett SW, Hagensee ME. Hyperthyroidism induced by iodinated glycerol . Am Rev Respir Dis . 1991;144:1403.Crossref 6. Block SH. Goiter complicating therapy with iodinated glycerol (Organidin) . J Pediatr . 1973;83:84-86.Crossref 7. Olin BR, ed. Drug Facts and Comparisons . St Louis, Mo: JB Lippincott Co; 1991:198. 8. McEvoy GK, ed. American Hospital Formulary Service Drug Information . Bethesda, Md: American Society of Hospital Pharmacists Inc; 1992:1603.

Journal

Archives of Internal MedicineAmerican Medical Association

Published: May 23, 1994

References