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Involvement of the Nervous System in Hairy-Cell Leukemia

Involvement of the Nervous System in Hairy-Cell Leukemia Abstract To the Editor. —We read with interest the article on "Neurologic Complications of Hairy-Cell Leukemia" by Kimmel et al.1 These authors claim that, as far as they know, no welldocumented clinicopathologic study of central nervous system infiltration by hairy-cell leukemia has been reported. Of the 108 cases that these authors reviewed, neurologic complications developed in eight cases and no case of direct infiltration of the central nervous system was observed. Our purpose is to draw attention to a clinicopathologic case of hairy-cell leukemia with infiltration of the brain that we reported in a French journal several years ago.2 Report of a Case. —A 35-year-old man was admitted to a hospital with progressive weakness and splenomegaly. The blood film, the myelogram, and the bone marrow biopsy led to a diagnosis of splenic and medullary histiolymphocytosis. Four months later, the patient developed an infectious syndrome and a meningeal syndrome. References 1. Kimmel DW, Herman RC Jr, O'Neill BP: Neurologic complications of hairy-cell leukemia . Arch Neurol 1984;41:202-203.Crossref 2. Gouygou C, Le Bezu M, Poirier J, et al: Histiolymphocytose ou leucémie histiolymphocytaire avec localisations encéphaliques: Etude anatomopathologique et neuropathologique d'un cas . Ann Anat Pathol 1971;16:309-320. 3. Boiron M, Flandrin G, Ripault J, et al: Histiolymphocytose médullaire et splénique d'apparence primitive . Nouv Rev Fr Hematol 1968;8:179-200. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology American Medical Association

Involvement of the Nervous System in Hairy-Cell Leukemia

Involvement of the Nervous System in Hairy-Cell Leukemia

Abstract

Abstract To the Editor. —We read with interest the article on "Neurologic Complications of Hairy-Cell Leukemia" by Kimmel et al.1 These authors claim that, as far as they know, no welldocumented clinicopathologic study of central nervous system infiltration by hairy-cell leukemia has been reported. Of the 108 cases that these authors reviewed, neurologic complications developed in eight cases and no case of direct infiltration of the central nervous system was observed. Our...
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Publisher
American Medical Association
Copyright
Copyright © 1986 American Medical Association. All Rights Reserved.
ISSN
0003-9942
eISSN
1538-3687
DOI
10.1001/archneur.1986.00520050012010
Publisher site
See Article on Publisher Site

Abstract

Abstract To the Editor. —We read with interest the article on "Neurologic Complications of Hairy-Cell Leukemia" by Kimmel et al.1 These authors claim that, as far as they know, no welldocumented clinicopathologic study of central nervous system infiltration by hairy-cell leukemia has been reported. Of the 108 cases that these authors reviewed, neurologic complications developed in eight cases and no case of direct infiltration of the central nervous system was observed. Our purpose is to draw attention to a clinicopathologic case of hairy-cell leukemia with infiltration of the brain that we reported in a French journal several years ago.2 Report of a Case. —A 35-year-old man was admitted to a hospital with progressive weakness and splenomegaly. The blood film, the myelogram, and the bone marrow biopsy led to a diagnosis of splenic and medullary histiolymphocytosis. Four months later, the patient developed an infectious syndrome and a meningeal syndrome. References 1. Kimmel DW, Herman RC Jr, O'Neill BP: Neurologic complications of hairy-cell leukemia . Arch Neurol 1984;41:202-203.Crossref 2. Gouygou C, Le Bezu M, Poirier J, et al: Histiolymphocytose ou leucémie histiolymphocytaire avec localisations encéphaliques: Etude anatomopathologique et neuropathologique d'un cas . Ann Anat Pathol 1971;16:309-320. 3. Boiron M, Flandrin G, Ripault J, et al: Histiolymphocytose médullaire et splénique d'apparence primitive . Nouv Rev Fr Hematol 1968;8:179-200.

Journal

Archives of NeurologyAmerican Medical Association

Published: May 1, 1986

References