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Investigations of Tocopherol Deficiency in Infancy and Childhood: Studies of Ceroid Pigment Deposition

Investigations of Tocopherol Deficiency in Infancy and Childhood: Studies of Ceroid Pigment... Abstract The tocopherols, or vitamin E-active substances have received fitful scientific attention and occasional notoriety in recent years. Reproducible tocopherol deficiency states have been well documented as they affect a wide variety of tissues in various species of experimental animals. The signs of tocopherol deficiency in experimental animals most frequently appear in the reproductive system, smooth and skeletal muscles, blood vessels, and the hematopoietic system. To date, no clinical syndrome of tocopherol deficiency has been defined in man. Progress in the understanding of the role of tocopherol in human physiology has undoubtedly been hampered by its widespread and often uncontrolled therapeutic use for conditions in which tocopherol deficiency has never been demonstrated. Facetious slogans, such as "E for Everything" have surely diverted the serious investigator's attention from tocopherol, which Gordon has aptly called a "shady lady to be approached gingerly by respectable or discreet investigators in human nutrition."1 The pediatric References 1. Gordon, H. H.; Nitowsky, H. M.; Tildon, J. T., and Levin, S.: Studies of Tocopherol Deficiency in Infants and Children: V. An Interim Summary , Pediatrics 21:673, 1958. 2. Wright, S. W.; Filer, L. J., and Mason, K. E.: Vitamin E Blood Levels in Premature and Full Term Infants , Pediatrics 7:386, 1951. 3. Dju, M. Y.; Mason, K. E., and Filer, L. J.: Vitamin E (Tocopherol) in Human Fetuses and Placentae , Études néo-natal . 1:49, 1952. 4. Horwitt, M. K.; Harvey, C. C.; Duncan, G. D., and Wilson, W. C.: Effects of Limited Tocopherol Intakes in Man with Relationship to Erythrocyte Hemolysis and Lipid Oxidations , Am. J. Clin. Nutrition 4:408, 1956. 5. Nitowsky, H. M.; Gordon, H. H., and Tildon, J. T.: Studies of Tocopherol Deficiency in Infants and Children: IV. The Effect of Alpha Tocopherol on Creatinuria in Patients with Cystic Fibrosis of the Pancreas and Biliary Atresia , Bull. Johns Hopkins Hosp. 98:361, 1956. 6. Blanc, W. A.; Reid, J. D., and Andersen, D. H.: Avitaminosis E in Cystic Fibrosis of the Pancreas , Pediatrics 22:494, 1958. 7. Popper, H.; György, P., and Goldblatt, H.: Fluorescent Material (Ceroid) in Experimental Nutritional Cirrhosis , Arch. Path. 37:161, 1944. 8. Pappenheimer, A. M., and Victor, J.: "Ceroid" Pigment in Human Tissues , Am. J. Path. 22:395, 1956. 9. MacKenzie, J. B.: Relation Between Serum Tocopherol and Hemolysis in Hydrogen Peroxide of Erythrocytes in Premature Infants , Pediatrics 13:346, 1954. 10. Nitowsky, H. M.; Cornblath, M., and Gordon, H. H.: Studies of Tocopherol Deficiency in Infants and Children: II. Plasma Tocopherol and Erythrocyte Hemolysis in Hydrogen Peroxide , A.M.A. J. Dis. Child. 92:164, 1956.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Journal of Diseases of Children American Medical Association

Investigations of Tocopherol Deficiency in Infancy and Childhood: Studies of Ceroid Pigment Deposition

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Publisher
American Medical Association
Copyright
Copyright © 1960 American Medical Association. All Rights Reserved.
ISSN
0096-6916
DOI
10.1001/archpedi.1960.02070030599005
Publisher site
See Article on Publisher Site

Abstract

Abstract The tocopherols, or vitamin E-active substances have received fitful scientific attention and occasional notoriety in recent years. Reproducible tocopherol deficiency states have been well documented as they affect a wide variety of tissues in various species of experimental animals. The signs of tocopherol deficiency in experimental animals most frequently appear in the reproductive system, smooth and skeletal muscles, blood vessels, and the hematopoietic system. To date, no clinical syndrome of tocopherol deficiency has been defined in man. Progress in the understanding of the role of tocopherol in human physiology has undoubtedly been hampered by its widespread and often uncontrolled therapeutic use for conditions in which tocopherol deficiency has never been demonstrated. Facetious slogans, such as "E for Everything" have surely diverted the serious investigator's attention from tocopherol, which Gordon has aptly called a "shady lady to be approached gingerly by respectable or discreet investigators in human nutrition."1 The pediatric References 1. Gordon, H. H.; Nitowsky, H. M.; Tildon, J. T., and Levin, S.: Studies of Tocopherol Deficiency in Infants and Children: V. An Interim Summary , Pediatrics 21:673, 1958. 2. Wright, S. W.; Filer, L. J., and Mason, K. E.: Vitamin E Blood Levels in Premature and Full Term Infants , Pediatrics 7:386, 1951. 3. Dju, M. Y.; Mason, K. E., and Filer, L. J.: Vitamin E (Tocopherol) in Human Fetuses and Placentae , Études néo-natal . 1:49, 1952. 4. Horwitt, M. K.; Harvey, C. C.; Duncan, G. D., and Wilson, W. C.: Effects of Limited Tocopherol Intakes in Man with Relationship to Erythrocyte Hemolysis and Lipid Oxidations , Am. J. Clin. Nutrition 4:408, 1956. 5. Nitowsky, H. M.; Gordon, H. H., and Tildon, J. T.: Studies of Tocopherol Deficiency in Infants and Children: IV. The Effect of Alpha Tocopherol on Creatinuria in Patients with Cystic Fibrosis of the Pancreas and Biliary Atresia , Bull. Johns Hopkins Hosp. 98:361, 1956. 6. Blanc, W. A.; Reid, J. D., and Andersen, D. H.: Avitaminosis E in Cystic Fibrosis of the Pancreas , Pediatrics 22:494, 1958. 7. Popper, H.; György, P., and Goldblatt, H.: Fluorescent Material (Ceroid) in Experimental Nutritional Cirrhosis , Arch. Path. 37:161, 1944. 8. Pappenheimer, A. M., and Victor, J.: "Ceroid" Pigment in Human Tissues , Am. J. Path. 22:395, 1956. 9. MacKenzie, J. B.: Relation Between Serum Tocopherol and Hemolysis in Hydrogen Peroxide of Erythrocytes in Premature Infants , Pediatrics 13:346, 1954. 10. Nitowsky, H. M.; Cornblath, M., and Gordon, H. H.: Studies of Tocopherol Deficiency in Infants and Children: II. Plasma Tocopherol and Erythrocyte Hemolysis in Hydrogen Peroxide , A.M.A. J. Dis. Child. 92:164, 1956.Crossref

Journal

A.M.A. Journal of Diseases of ChildrenAmerican Medical Association

Published: May 1, 1960

References