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Introduction of Sodium Diphenyl Hydantoinate

Introduction of Sodium Diphenyl Hydantoinate Had the discovery of the anticonvulsant properties of sodium diphenyl hydantoinate been fortuitous, an article first reporting the effectiveness of this drug in man would justify its inclusion as a landmark article in the centennial celebration issues of JAMA. This drug, now called phenytoin (Dilantin), soon revolutionized the drug treatment of the convulsive disorders when such treatment had been largely limited to the bromides and phenobarbital. Phenytoin remains today a mainstay of therapy in the control of major motor seizures and some other manifestations of epilepsy. Few drugs continue in active use in unmodified form 45 years after the discovery of their usefulness. Few drugs have been as important for the relief of human disability and suffering, and this with an acceptable level of side and toxic effects in most patients. That phenytoin was chosen by logical inference to be included in a series of drugs actively tested for effectiveness http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Introduction of Sodium Diphenyl Hydantoinate

JAMA , Volume 251 (8) – Feb 24, 1984

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Publisher
American Medical Association
Copyright
Copyright © 1984 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.1984.03340320054028
Publisher site
See Article on Publisher Site

Abstract

Had the discovery of the anticonvulsant properties of sodium diphenyl hydantoinate been fortuitous, an article first reporting the effectiveness of this drug in man would justify its inclusion as a landmark article in the centennial celebration issues of JAMA. This drug, now called phenytoin (Dilantin), soon revolutionized the drug treatment of the convulsive disorders when such treatment had been largely limited to the bromides and phenobarbital. Phenytoin remains today a mainstay of therapy in the control of major motor seizures and some other manifestations of epilepsy. Few drugs continue in active use in unmodified form 45 years after the discovery of their usefulness. Few drugs have been as important for the relief of human disability and suffering, and this with an acceptable level of side and toxic effects in most patients. That phenytoin was chosen by logical inference to be included in a series of drugs actively tested for effectiveness

Journal

JAMAAmerican Medical Association

Published: Feb 24, 1984

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