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Intravitreal Expanding Gas Bubble: A Morphologic Study in the Rabbit Eye

Intravitreal Expanding Gas Bubble: A Morphologic Study in the Rabbit Eye Abstract • The morphologic changes induced by an expanding bubble of perfluoropropane (C3F8) gas in the vitreous body have been studied in the rabbit eye by dissecting microscopy and scanning and transmission electron microscopy. Initial expansion of the gas displaces water from the vitreous; the remaining vitreous forms a compressed layer on the retinal surface. Subsequent absorption and contraction of the gas bubble is associated with gradual detachment of the compressed vitreous from the retina. Eventually, vitreous detachment is complete, except for residual attachments posteriorly to the medullary rays and anteriorly to the ciliary processes. The plane of vitreous separation is predominantly at the anatomic vitreoretinal junction, although scattered islands of outer cortical vitreous are found on the surface of the retina. References 1. Rosengren B: Results of treatment of detachment of the retina with diathermy and injection of air into the vitreous . Acta Ophthalmol 1938;16:573-579.Crossref 2. Norton EWD: Intraocular gas in the management of selected retinal detachments . Trans Am Acad Ophthalmol Otolaryngol 1973;77:85-98. 3. Lincoff A, Haft D, Liggett P, et al: Intravitreal expansion of perfluorocarbon bubbles . Arch Ophthalmol 1980;98:1646.Crossref 4. Lincoff A, Lincoff H, Iwamoto T, et al: Perfluoro-n-butane: A gas for maximum duration retinal tamponade . Arch Ophthalmol 1983; 101:460-462.Crossref 5. Machemer R: Vitreous compression. Presented at the Fourth Vail Vitrectomy Symposium, Vail, Colo, March 13, 1983. 6. Thresher R, Ehrenberg M, Chandler D, et al: Vitreous compression: An experimental alternative to vitrectomy . Invest Ophthalmol Vis Sci 1983;24( (suppl) ):242. 7. Parver LM, Lincoff H: Mechanics of intraocular gas . Invest Ophthalmol Vis Sci 1978;17:77-79. 8. Abrams GW, Edelhauser HF, Aaberg TM, et al: Dynamics of intravitreal sulfur hexafluoride gas . Invest Ophthalmol Vis Sci 1974;13:863-868. 9. Lincoff A, Kreissig I: Intravitreal behavior of perfluorocarbons . Dev Ophthalmol 1981;2:17-23. 10. Fineberg E, Machemer R, Sullivan P: SF6 for retinal detachment surgery: A preliminary report . Mod Probl Ophthalmol 1974;12:173-176. 11. Lincoff H, Kreissig I: Posterior lip traction caused by intravitreal gas . Arch Ophthalmol 1981;99:1367-1370.Crossref 12. Constable IJ, Swann DA: Vitreous substitution with gases . Arch Ophthalmol 1975;93:416-419.Crossref 13. Lincoff H, Coleman J, Kreissig I, et al: The perfluorocarbon gases in the treatment of retinal detachment . Ophthalmology 1983;90:546-551.Crossref 14. Moseley H, Foulds WS: Tracer movement across the rabbit retina . Doc Ophthalmol 1981; 25:87-91. 15. Balazs EA: Functional anatomy of the vitreous , in Jakobiec FA (ed): Ocular Anatomy, Embryology, and Teratology . Hagerstown, Md, Harper & Row Publishers Inc, 1982, pp 425-440. 16. Balazs EA: Molecular morphology of the vitreous body , in Smelser GK (ed): The Structure of the Eye. New York, Academic Press Inc, 1961, pp 293-310. 17. Matsumoto B, Blanks JC, Ryan SJ: Topographic variations in the rabbit and primate internal limiting membrane . Invest Ophthalmol Vis Sci 1984;25:71-82. 18. Foos RY: Posterior vitreous detachment . Trans Am Acad Ophthalmol Otolaryngol 1972; 76:480-497. 19. Eisner B: Biomicroscopy of the Peripheral Fundus: An Atlas and Textbook . New York, Springer-Verlag Inc, 1973. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Intravitreal Expanding Gas Bubble: A Morphologic Study in the Rabbit Eye

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Publisher
American Medical Association
Copyright
Copyright © 1984 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1984.01040031392034
Publisher site
See Article on Publisher Site

Abstract

Abstract • The morphologic changes induced by an expanding bubble of perfluoropropane (C3F8) gas in the vitreous body have been studied in the rabbit eye by dissecting microscopy and scanning and transmission electron microscopy. Initial expansion of the gas displaces water from the vitreous; the remaining vitreous forms a compressed layer on the retinal surface. Subsequent absorption and contraction of the gas bubble is associated with gradual detachment of the compressed vitreous from the retina. Eventually, vitreous detachment is complete, except for residual attachments posteriorly to the medullary rays and anteriorly to the ciliary processes. The plane of vitreous separation is predominantly at the anatomic vitreoretinal junction, although scattered islands of outer cortical vitreous are found on the surface of the retina. References 1. Rosengren B: Results of treatment of detachment of the retina with diathermy and injection of air into the vitreous . Acta Ophthalmol 1938;16:573-579.Crossref 2. Norton EWD: Intraocular gas in the management of selected retinal detachments . Trans Am Acad Ophthalmol Otolaryngol 1973;77:85-98. 3. Lincoff A, Haft D, Liggett P, et al: Intravitreal expansion of perfluorocarbon bubbles . Arch Ophthalmol 1980;98:1646.Crossref 4. Lincoff A, Lincoff H, Iwamoto T, et al: Perfluoro-n-butane: A gas for maximum duration retinal tamponade . Arch Ophthalmol 1983; 101:460-462.Crossref 5. Machemer R: Vitreous compression. Presented at the Fourth Vail Vitrectomy Symposium, Vail, Colo, March 13, 1983. 6. Thresher R, Ehrenberg M, Chandler D, et al: Vitreous compression: An experimental alternative to vitrectomy . Invest Ophthalmol Vis Sci 1983;24( (suppl) ):242. 7. Parver LM, Lincoff H: Mechanics of intraocular gas . Invest Ophthalmol Vis Sci 1978;17:77-79. 8. Abrams GW, Edelhauser HF, Aaberg TM, et al: Dynamics of intravitreal sulfur hexafluoride gas . Invest Ophthalmol Vis Sci 1974;13:863-868. 9. Lincoff A, Kreissig I: Intravitreal behavior of perfluorocarbons . Dev Ophthalmol 1981;2:17-23. 10. Fineberg E, Machemer R, Sullivan P: SF6 for retinal detachment surgery: A preliminary report . Mod Probl Ophthalmol 1974;12:173-176. 11. Lincoff H, Kreissig I: Posterior lip traction caused by intravitreal gas . Arch Ophthalmol 1981;99:1367-1370.Crossref 12. Constable IJ, Swann DA: Vitreous substitution with gases . Arch Ophthalmol 1975;93:416-419.Crossref 13. Lincoff H, Coleman J, Kreissig I, et al: The perfluorocarbon gases in the treatment of retinal detachment . Ophthalmology 1983;90:546-551.Crossref 14. Moseley H, Foulds WS: Tracer movement across the rabbit retina . Doc Ophthalmol 1981; 25:87-91. 15. Balazs EA: Functional anatomy of the vitreous , in Jakobiec FA (ed): Ocular Anatomy, Embryology, and Teratology . Hagerstown, Md, Harper & Row Publishers Inc, 1982, pp 425-440. 16. Balazs EA: Molecular morphology of the vitreous body , in Smelser GK (ed): The Structure of the Eye. New York, Academic Press Inc, 1961, pp 293-310. 17. Matsumoto B, Blanks JC, Ryan SJ: Topographic variations in the rabbit and primate internal limiting membrane . Invest Ophthalmol Vis Sci 1984;25:71-82. 18. Foos RY: Posterior vitreous detachment . Trans Am Acad Ophthalmol Otolaryngol 1972; 76:480-497. 19. Eisner B: Biomicroscopy of the Peripheral Fundus: An Atlas and Textbook . New York, Springer-Verlag Inc, 1973.

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Nov 1, 1984

References