Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You and Your Team.

Learn More →

Intravitreal Aminoglycoside Toxicity Revisited-Reply

Intravitreal Aminoglycoside Toxicity Revisited-Reply This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables. Abstract In Reply. —We appreciate the interest and concern of Dr Pulido et al regarding the determination of aminoglycoside toxicity following intravitreal administration. Basic toxicity studies are performed for safety assessment so we can predict the likely adverse effects of a drug in humans. Two objectives of toxicity studies include defining a nontoxic (no observable effect) dose level and a toxic dose level. The characterization of the dose-response relationship for toxic effects observed at doses above the no-effect level is vital. Two approaches can be undertaken to achieve the objectives: incremental increases in the drug-dose level, and a log-dose interval, as suggested by Dr Pulido et al.An experimental data set with a dose-response relationship over several log units of drug dose may allow reliable interpretation of the results and perhaps extrapolation of the results to humans, as stated by Dr Pulido et al. The log doseresponse relationship is critically important http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Intravitreal Aminoglycoside Toxicity Revisited-Reply

Download PDF
1 page
Read Article

Intravitreal Aminoglycoside Toxicity Revisited-Reply

Abstract

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables. Abstract In Reply. —We appreciate the interest and concern of Dr Pulido et al regarding the determination of aminoglycoside toxicity following intravitreal administration. Basic toxicity studies are performed for safety assessment so we can predict the likely adverse effects of a drug in humans. Two objectives of toxicity studies include defining a...
Loading next page...
 
/lp/american-medical-association/intravitreal-aminoglycoside-toxicity-revisited-reply-m3dDDyl8VG
Publisher
American Medical Association
Copyright
Copyright © 1992 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1992.01080240021010
Publisher site
See Article on Publisher Site

Abstract

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables. Abstract In Reply. —We appreciate the interest and concern of Dr Pulido et al regarding the determination of aminoglycoside toxicity following intravitreal administration. Basic toxicity studies are performed for safety assessment so we can predict the likely adverse effects of a drug in humans. Two objectives of toxicity studies include defining a nontoxic (no observable effect) dose level and a toxic dose level. The characterization of the dose-response relationship for toxic effects observed at doses above the no-effect level is vital. Two approaches can be undertaken to achieve the objectives: incremental increases in the drug-dose level, and a log-dose interval, as suggested by Dr Pulido et al.An experimental data set with a dose-response relationship over several log units of drug dose may allow reliable interpretation of the results and perhaps extrapolation of the results to humans, as stated by Dr Pulido et al. The log doseresponse relationship is critically important

Journal

Archives of Ophthalmology – American Medical Association

Published: Dec 1, 1992

There are no references for this article.

You’re reading a free preview. Subscribe to read the entire article.

Try 2 weeks free now

DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

or browse the journals available

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$499/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

Sign up
for free
Start 14 day
Free Trial