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Intravitreal Aminoglycoside Toxicity Revisited-Reply

Intravitreal Aminoglycoside Toxicity Revisited-Reply This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables. Abstract In Reply. —We appreciate the interest and concern of Dr Pulido et al regarding the determination of aminoglycoside toxicity following intravitreal administration. Basic toxicity studies are performed for safety assessment so we can predict the likely adverse effects of a drug in humans. Two objectives of toxicity studies include defining a nontoxic (no observable effect) dose level and a toxic dose level. The characterization of the dose-response relationship for toxic effects observed at doses above the no-effect level is vital. Two approaches can be undertaken to achieve the objectives: incremental increases in the drug-dose level, and a log-dose interval, as suggested by Dr Pulido et al.An experimental data set with a dose-response relationship over several log units of drug dose may allow reliable interpretation of the results and perhaps extrapolation of the results to humans, as stated by Dr Pulido et al. The log doseresponse relationship is critically important http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Intravitreal Aminoglycoside Toxicity Revisited-Reply

Intravitreal Aminoglycoside Toxicity Revisited-Reply

Abstract

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables. Abstract In Reply. —We appreciate the interest and concern of Dr Pulido et al regarding the determination of aminoglycoside toxicity following intravitreal administration. Basic toxicity studies are performed for safety assessment so we can predict the likely adverse effects of a drug in humans. Two objectives of toxicity studies include defining a...
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Publisher
American Medical Association
Copyright
Copyright © 1992 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1992.01080240021010
Publisher site
See Article on Publisher Site

Abstract

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables. Abstract In Reply. —We appreciate the interest and concern of Dr Pulido et al regarding the determination of aminoglycoside toxicity following intravitreal administration. Basic toxicity studies are performed for safety assessment so we can predict the likely adverse effects of a drug in humans. Two objectives of toxicity studies include defining a nontoxic (no observable effect) dose level and a toxic dose level. The characterization of the dose-response relationship for toxic effects observed at doses above the no-effect level is vital. Two approaches can be undertaken to achieve the objectives: incremental increases in the drug-dose level, and a log-dose interval, as suggested by Dr Pulido et al.An experimental data set with a dose-response relationship over several log units of drug dose may allow reliable interpretation of the results and perhaps extrapolation of the results to humans, as stated by Dr Pulido et al. The log doseresponse relationship is critically important

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Dec 1, 1992

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