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INTRAVITAM BONE MARROW STUDIES: PART II SURVEY OF THE CLINICAL FIELD

INTRAVITAM BONE MARROW STUDIES: PART II SURVEY OF THE CLINICAL FIELD Abstract In Part 1 we demonstrated that bone marrow puncture in animals is a comparatively simple and harmless procedure and that it is a feasible and practical method of studying (in rabbits) both normal and pathologic bone marrows, yielding nearly as much information as fixation and sectioning of marrow obtained postmortem. Before proceeding to the clinical application of this method, on the patient, it became necessary to satisfy ourselves regarding certain questions that were uppermost in our minds during the experimental work. Can the puncture be accomplished without pain and discomfort to the patient and is it safe?—After trying it out several times on cadavers, we became convinced that the cortex of the tibia could be pierced easily and quickly. We felt that it would be a simple matter to anesthetize the skin and periosteum so that the procedure would be practically painless. The question of safety will be dealt with References 1. Schultze: Beitr. z. path. Anat. u. z. allg. Path. 45:127, 1909. 2. Marchand: Verhandl. d. Deutsch. path. Gesellsch. 16, 1913. 3. Reed: Am. J. M. Sc. 124:653, 1902.Crossref 4. Sternberg: Beitr. z. Path. Anat. u. z. allg. Path. 61:77, 1916. 5. Herxheimer: Muench. med. Wchnschr. 60:2506, 1913. 6. Webster: Johns Hopkins Hosp. Bull. 31:458, 1920. 7. MacCullum: A Textbook of Pathology , Ed. 2. W. B. Saunders, Philadelphia, p. 835. 8. Hirschfeld: Ergebn. d. Inn. Med. in Kinderh. 7:164, 1911. 9. Strauch: Med. Rec. 86:713, 1914. 10. Naegeli: Leukaemia und Pseudoleukaemia . Wien., 1913. 11. Barker: Tr. Ass. Am. Phys. 32:46, 1917. 12. Citron: Folia haematol. 20:1, 1915. 13. Ewald: Berl. klin. Wchnschr. 43:870, 1906. 14. Beltz: Deutsch. Arch. f. klin. Med. 113:116, 1913. 15. Sternberg: Wien. klin. Wchnschr. 26:553 ( (June) ) 1920. 16. Morawitz: Deutsch. Arch. f. klin. Med. 88:493, 1906. 17. Kleinschmidt: Jahrb. f. Kinderh. 81:1, 1915. 18. Hirschfeld: Berl. klin. Wchnschr. 43: 545, 1906. 19. Sternberg: Wien. klin. Wchnschr. 24:1623, 1911. 20. Cabot: Osler and McCrae , Modern Medicine , 4:676. 21. Jackson and Smith: Boston M. & S. J. 172:136, 1915. 22. Simon: Am. J. M. Sc. 132:144, 1906. 23. Stevens: Lancet 2:791, 1902. 24. Rotch and Morse: Boston M. & S. J. 152:729, 1905. 25. Wilbur: J. A. M. A. 65:1255 ( (Oct. 9) ) 1915. 26. Ward: Brit. J. Child. Dis. 14:10, 1917. 27. Minot: Oxford Medicine 2, 1920. 28. Bunting: Johns Hopkins Hosp. Bull. 36:222, 1905. 29. Minot and Lee: Boston M. & S. J. 177:761, 1917. 30. Ellermann: Acta Med. Scandinavica 53:718, 1919. 31. Evans: Anat. Rec. 8:98, 99, 1914. 32. Weber & Watson: Internat. Clin. 4:47, 1905. 33. Blumenthal: Bull. de 1'Acad. Roy. de méd. de Belgique , Ser. 19, 1905-4. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

INTRAVITAM BONE MARROW STUDIES: PART II SURVEY OF THE CLINICAL FIELD

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Publisher
American Medical Association
Copyright
Copyright © 1922 American Medical Association. All Rights Reserved.
ISSN
0730-188X
DOI
10.1001/archinte.1922.00110100084006
Publisher site
See Article on Publisher Site

Abstract

Abstract In Part 1 we demonstrated that bone marrow puncture in animals is a comparatively simple and harmless procedure and that it is a feasible and practical method of studying (in rabbits) both normal and pathologic bone marrows, yielding nearly as much information as fixation and sectioning of marrow obtained postmortem. Before proceeding to the clinical application of this method, on the patient, it became necessary to satisfy ourselves regarding certain questions that were uppermost in our minds during the experimental work. Can the puncture be accomplished without pain and discomfort to the patient and is it safe?—After trying it out several times on cadavers, we became convinced that the cortex of the tibia could be pierced easily and quickly. We felt that it would be a simple matter to anesthetize the skin and periosteum so that the procedure would be practically painless. The question of safety will be dealt with References 1. Schultze: Beitr. z. path. Anat. u. z. allg. Path. 45:127, 1909. 2. Marchand: Verhandl. d. Deutsch. path. Gesellsch. 16, 1913. 3. Reed: Am. J. M. Sc. 124:653, 1902.Crossref 4. Sternberg: Beitr. z. Path. Anat. u. z. allg. Path. 61:77, 1916. 5. Herxheimer: Muench. med. Wchnschr. 60:2506, 1913. 6. Webster: Johns Hopkins Hosp. Bull. 31:458, 1920. 7. MacCullum: A Textbook of Pathology , Ed. 2. W. B. Saunders, Philadelphia, p. 835. 8. Hirschfeld: Ergebn. d. Inn. Med. in Kinderh. 7:164, 1911. 9. Strauch: Med. Rec. 86:713, 1914. 10. Naegeli: Leukaemia und Pseudoleukaemia . Wien., 1913. 11. Barker: Tr. Ass. Am. Phys. 32:46, 1917. 12. Citron: Folia haematol. 20:1, 1915. 13. Ewald: Berl. klin. Wchnschr. 43:870, 1906. 14. Beltz: Deutsch. Arch. f. klin. Med. 113:116, 1913. 15. Sternberg: Wien. klin. Wchnschr. 26:553 ( (June) ) 1920. 16. Morawitz: Deutsch. Arch. f. klin. Med. 88:493, 1906. 17. Kleinschmidt: Jahrb. f. Kinderh. 81:1, 1915. 18. Hirschfeld: Berl. klin. Wchnschr. 43: 545, 1906. 19. Sternberg: Wien. klin. Wchnschr. 24:1623, 1911. 20. Cabot: Osler and McCrae , Modern Medicine , 4:676. 21. Jackson and Smith: Boston M. & S. J. 172:136, 1915. 22. Simon: Am. J. M. Sc. 132:144, 1906. 23. Stevens: Lancet 2:791, 1902. 24. Rotch and Morse: Boston M. & S. J. 152:729, 1905. 25. Wilbur: J. A. M. A. 65:1255 ( (Oct. 9) ) 1915. 26. Ward: Brit. J. Child. Dis. 14:10, 1917. 27. Minot: Oxford Medicine 2, 1920. 28. Bunting: Johns Hopkins Hosp. Bull. 36:222, 1905. 29. Minot and Lee: Boston M. & S. J. 177:761, 1917. 30. Ellermann: Acta Med. Scandinavica 53:718, 1919. 31. Evans: Anat. Rec. 8:98, 99, 1914. 32. Weber & Watson: Internat. Clin. 4:47, 1905. 33. Blumenthal: Bull. de 1'Acad. Roy. de méd. de Belgique , Ser. 19, 1905-4.

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Oct 1, 1922

References