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INTRAVENOUS VACCINE THERAPY IN STAPHYLOCOCCIC INFECTIONS

INTRAVENOUS VACCINE THERAPY IN STAPHYLOCOCCIC INFECTIONS Abstract The therapy described in this paper was suggested by a series of experiments carried out in studying the results of treatment with vaccine in animals made hypersensitive to streptococci in an attempt to find a basis for vaccine therapy in acute rheumatic fever. These animals were made hypersensitive (allergic) by subcutaneous injection into one area of agar at 45 C. heavily seeded with streptococci. This method of producing and maintaining an allergic state had been demonstrated by Swift.1 In from twelve to eighteen days after the initial sensitizing dose, the animals were given subcutaneous injections by the method previously used in producing experimental rheumatoid subcutaneous nodules.2 Into ten places on the right side of the back of each animal was injected subcutaneously 11/100 of a standard amount of streptococci and into ten places on the left side,1/1,000 of the amount. In a former series of experiments with increasing References 1. Swift, H. F.: Reaction of Rabbits to Nonhemolytic Streptococci , J. Exper. Med. 49:615, 1929.Crossref 2. Clawson, B. J.: Experimental Streptococcic Inflammation in Normal, Immune and Hypersensitive Animals , Arch. Path. 9:1142 ( (June) ) 1930. 3. Michelson, H. E., and Allen, P. K.: Acne Conglobata , Arch. Dermat. & Syph. 23:49 ( (Jan.) ) 1931. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology and Syphilology American Medical Association

INTRAVENOUS VACCINE THERAPY IN STAPHYLOCOCCIC INFECTIONS

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Publisher
American Medical Association
Copyright
Copyright © 1931 American Medical Association. All Rights Reserved.
ISSN
0096-6029
DOI
10.1001/archderm.1931.03880230070008
Publisher site
See Article on Publisher Site

Abstract

Abstract The therapy described in this paper was suggested by a series of experiments carried out in studying the results of treatment with vaccine in animals made hypersensitive to streptococci in an attempt to find a basis for vaccine therapy in acute rheumatic fever. These animals were made hypersensitive (allergic) by subcutaneous injection into one area of agar at 45 C. heavily seeded with streptococci. This method of producing and maintaining an allergic state had been demonstrated by Swift.1 In from twelve to eighteen days after the initial sensitizing dose, the animals were given subcutaneous injections by the method previously used in producing experimental rheumatoid subcutaneous nodules.2 Into ten places on the right side of the back of each animal was injected subcutaneously 11/100 of a standard amount of streptococci and into ten places on the left side,1/1,000 of the amount. In a former series of experiments with increasing References 1. Swift, H. F.: Reaction of Rabbits to Nonhemolytic Streptococci , J. Exper. Med. 49:615, 1929.Crossref 2. Clawson, B. J.: Experimental Streptococcic Inflammation in Normal, Immune and Hypersensitive Animals , Arch. Path. 9:1142 ( (June) ) 1930. 3. Michelson, H. E., and Allen, P. K.: Acne Conglobata , Arch. Dermat. & Syph. 23:49 ( (Jan.) ) 1931.

Journal

Archives of Dermatology and SyphilologyAmerican Medical Association

Published: May 1, 1931

References