Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You and Your Team.

Learn More →

INTRAVENOUS INJECTION OF ERGOT.

INTRAVENOUS INJECTION OF ERGOT. Ergot is commonly supposed to produce a powerful and persistent contraction of blood vessels. This belief rests mainly on clinical evidence, which is not conclusive; even when the observations are correct, they generally admit of other explanations. For instance, the hemostatic action of ergot in postpartum hemorrhage is now referred to the contraction of the uterine muscle, rather than to a vasoconstriction. It is also generally assumed that the vasoconstriction has been firmly established by experimental evidence. An inspection of any of the critical text-books of pharmacology, however, will suffice to show that different investigators have obtained variable results on mammals. This caused us to undertake the present investigation, the original object of which was to determine, on dogs, the circulatory effects of the ergot preparations as found on the market, in therapeutic doses, normally and in the pathologic conditions in which the drug is recommended. We intended to use http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

INTRAVENOUS INJECTION OF ERGOT.

JAMA , Volume XLV (4) – Jul 22, 1905

Loading next page...
 
/lp/american-medical-association/intravenous-injection-of-ergot-akFvwcweqP
Publisher
American Medical Association
Copyright
Copyright © 1905 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.1905.52510040001001
Publisher site
See Article on Publisher Site

Abstract

Ergot is commonly supposed to produce a powerful and persistent contraction of blood vessels. This belief rests mainly on clinical evidence, which is not conclusive; even when the observations are correct, they generally admit of other explanations. For instance, the hemostatic action of ergot in postpartum hemorrhage is now referred to the contraction of the uterine muscle, rather than to a vasoconstriction. It is also generally assumed that the vasoconstriction has been firmly established by experimental evidence. An inspection of any of the critical text-books of pharmacology, however, will suffice to show that different investigators have obtained variable results on mammals. This caused us to undertake the present investigation, the original object of which was to determine, on dogs, the circulatory effects of the ergot preparations as found on the market, in therapeutic doses, normally and in the pathologic conditions in which the drug is recommended. We intended to use

Journal

JAMAAmerican Medical Association

Published: Jul 22, 1905

There are no references for this article.