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Intravenous Desensitization to Mechlorethamine in Patients With Psoriasis

Intravenous Desensitization to Mechlorethamine in Patients With Psoriasis Abstract • Eight patients with psoriasis who had developed contact allergy to mechlorethamine hydrochloride (nitrogen mustard) were subjected to a regimen of intravenous infusion of small amounts of the drug in an attempt to produce desensitization. Although three of eight developed negative patch tests and were presumed to be desensitized, only one patient was able to use the drug therapeutically, and then only for a period of eight months, after which allergy recurred. The other two patients whose allergic contact dermatitis was abolished by the infusions were unable to use mechlorethamine therapeutically because of pruritus. Seven patients experienced some adverse reaction to the infusion. Intravenous desensitization of psoriatic patients who are allergic to mechlorethamine was not successful enough as a useful clinical procedure to allow them to once again use the drug therapeutically. (Arch Dermatol 112:1113-1114, 1976) References 1. Van Scott EJ, Reinerson RP: Morphologic and physiologic effects of chemotherapeutic agents in psoriasis . J Invest Dermatol 33:357-362, 1959.Crossref 2. Epstein E, Ugel AR: Effects of topical mechlorethamine on the skin lesions of psoriasis . Arch Dermatol 102:504-506, 1970.Crossref 3. Mandy S, Taylor JR, Halprin K: Topically applied mechlorethamine in the treatment of psoriasis . Arch Dermatol 103:272-276, 1971.Crossref 4. Zackheim HS, Arnold JE, Farber EM, et al: Topical therapy of psoriasis with mechlorethamine . Arch Dermatol 105:702-706, 1972.Crossref 5. Taylor JR, Halprin K: Topical use of mechlorethamine in the treatment of psoriasis . Arch Dermatol 106:362-364, 1972.Crossref 6. Baer RL, Michaelides P, Prestia A: Failure to induce immune tolerance to nitrogen mustard . J Invest Dermatol 58:1-4, 1972.Crossref 7. Breza TS, Halprin KM, Taylor JR: Mechlorethamine in psoriasis . Arch Dermatol 111:1438, 1975.Crossref 8. Van Scott EJ, Kalmanson JD: Complete remission of mycosis fungoides lymphoma induced by topical nitrogen mustard (HN2) . Cancer 32:18-30, 1973.Crossref 9. Waldorf DS, Haynes HA, Van Scott EJ: Cutaneous hypersensitivity and desensitization to mechlorethamine in patients with mycosis fungoides lymphoma . Ann Intern Med 67:282, 1967.Crossref 10. Constantine VS, Fuks ZY, Farber EM: Mechlorethamine desensitization in therapy for mycosis fungoides . Arch Dermatol 111:484-488, 1975.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Intravenous Desensitization to Mechlorethamine in Patients With Psoriasis

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Publisher
American Medical Association
Copyright
Copyright © 1976 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1976.01630320023005
Publisher site
See Article on Publisher Site

Abstract

Abstract • Eight patients with psoriasis who had developed contact allergy to mechlorethamine hydrochloride (nitrogen mustard) were subjected to a regimen of intravenous infusion of small amounts of the drug in an attempt to produce desensitization. Although three of eight developed negative patch tests and were presumed to be desensitized, only one patient was able to use the drug therapeutically, and then only for a period of eight months, after which allergy recurred. The other two patients whose allergic contact dermatitis was abolished by the infusions were unable to use mechlorethamine therapeutically because of pruritus. Seven patients experienced some adverse reaction to the infusion. Intravenous desensitization of psoriatic patients who are allergic to mechlorethamine was not successful enough as a useful clinical procedure to allow them to once again use the drug therapeutically. (Arch Dermatol 112:1113-1114, 1976) References 1. Van Scott EJ, Reinerson RP: Morphologic and physiologic effects of chemotherapeutic agents in psoriasis . J Invest Dermatol 33:357-362, 1959.Crossref 2. Epstein E, Ugel AR: Effects of topical mechlorethamine on the skin lesions of psoriasis . Arch Dermatol 102:504-506, 1970.Crossref 3. Mandy S, Taylor JR, Halprin K: Topically applied mechlorethamine in the treatment of psoriasis . Arch Dermatol 103:272-276, 1971.Crossref 4. Zackheim HS, Arnold JE, Farber EM, et al: Topical therapy of psoriasis with mechlorethamine . Arch Dermatol 105:702-706, 1972.Crossref 5. Taylor JR, Halprin K: Topical use of mechlorethamine in the treatment of psoriasis . Arch Dermatol 106:362-364, 1972.Crossref 6. Baer RL, Michaelides P, Prestia A: Failure to induce immune tolerance to nitrogen mustard . J Invest Dermatol 58:1-4, 1972.Crossref 7. Breza TS, Halprin KM, Taylor JR: Mechlorethamine in psoriasis . Arch Dermatol 111:1438, 1975.Crossref 8. Van Scott EJ, Kalmanson JD: Complete remission of mycosis fungoides lymphoma induced by topical nitrogen mustard (HN2) . Cancer 32:18-30, 1973.Crossref 9. Waldorf DS, Haynes HA, Van Scott EJ: Cutaneous hypersensitivity and desensitization to mechlorethamine in patients with mycosis fungoides lymphoma . Ann Intern Med 67:282, 1967.Crossref 10. Constantine VS, Fuks ZY, Farber EM: Mechlorethamine desensitization in therapy for mycosis fungoides . Arch Dermatol 111:484-488, 1975.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: Aug 1, 1976

References