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Intravenous Administration of Modified Gamma Globulin: Several Studies on a Patient With Agammaglobulinemia

Intravenous Administration of Modified Gamma Globulin: Several Studies on a Patient With... Abstract Persons injected intravenously with human γ-globulin may develop symptoms which include anxiety, flushing of the face, a constricting feeling in the chest, muscle pain in the trunk or thighs, nausea and vomiting, fever, and rarely collapse.1-3 In one study seven of 54 subjects receiving 110 ml of 1.5% γ-globulin solution intravenously experienced a reaction.1 However, readministration, if within 72 hours, was well tolerated even by those who previously had reacted unfavorably. Individual susceptibility as well as rate of infusion, total amount given and perhaps the specific γ-globulin preparation may be determinants in the frequency and severity of symptoms. Peculiarly, the incidence of systemic reactions was extremely high in those with antibody deficiency syndromes such as primary agammaglobulinemia.1,4 By contrast, pepsin treated preparations of γ-globulin elicited few or no symptoms when given to people with a variety of diseases including agammaglobulinemia.5-7 The present report describes symptoms and laboratory findings observed during References 1. Barandun, S., et al: Intravenous Administration of Human γ-Globulin , Vox Sang 7:157-174, 1962.Crossref 2. Moore, G.E.; Sandberg, A.; and Amos, D.B.: Experimental and Clinical Adventures With Large Doses of Gamma and Other Globulins as Anticancer Agents , Surgery 41:972-983, 1957. 3. Coon, W.W., et al: Experiences With Large Infusions of γ-Globulin , Amer J Surg 102:548-553, 1961.Crossref 4. Hitzig, W.H., and Willi, H.: Hereditäre lymphoplasmocytäre Dysgenesie ("Alymphocytose mit Agammaglobulinämie") , Schweiz Med Wschr 91: 1625-1633, 1961. 5. Schultze, H.E., and Schwick, G.: Über neue Möglichkeiten intravenöser γ-globulin-Applikation , Deutsch Med Wschr 87:1643-1650, 1962.Crossref 6. Lang, W.: Die intravenöse γ-Globulin-Therapie , Deutsch Med Wschr 89:2374-2379, 1964.Crossref 7. Koch, F.: Erste Erfahrungen mit Gamma-VeninR, einem intravenös injizierbaren Gamma-globulin-Präparat, in der Kinderheilkunde , Deutsch Med Wschr 88:282-285, 1963.Crossref 8. Cohen, S.: Nomenclature of Human Immunoglobulins, editorial , Immunology 8:1-5, 1965. 9. Glaser, J., and Wyss-Souffront, W.A.: Alleged Anaphylactic Reactions to Human γ-Globulin , Pediatrics 28:367-376, 1961. 10. Squire, J.R.: Immunoglobulins , Proc Roy Soc Med 57:749-752, 1964. 11. Richerson, H.B., and Seebohm, P.M.: Anaphylactoid Reaction to Human γGlobulin , Arch Intern Med 117:568-572, 1966.Crossref 12. Richter, M., et al: Effects of Physicochemical Agents on the Electrophoretic Properties of Serum Proteins in Starch Gel Medium , Canad J Biochem 40:35-39, 1962.Crossref 13. Christian, C.L.: Studies on Aggregated γ-Globulin: I. Sedimentation, Electrophoretic, and Anticomplementary Properties , J Immun 84:112-116, 1960. 14. Christian, C.L.: Studies on Aggregated γ-Globulin: II. Effect in Vivo , J Immun 84:117-121, 1960. 15. Ishizaka, K.; Ishizaka, T.; and Sugahara, T.: Biologic Activity of Aggregated γGlobulin: III. Production of Arthus-like Reactions , J Immun 86: 220-227, 1961. 16. Benacerraf, B.; Sebestyen, M.; and Cooper, N.S.: The Clearance of Antigen Antibody Complexes from the Blood by the Reticulo-endothelial System , J Immun 82:131-137, 1959. 17. Barandun, S.; Kaiser, M.; and Dostal, V.: Zur Frage der intravenösen γGlobulin-Applikation , Helv Med Acta 28:551-555, 1961. 18. Tomasi, T.B., Jr.: Human γGlobulin Analytical Review , Blood 25:382-403, 1965. 19. Terry, W.D.; Fahey, J.L.; and Steinberg, A.G.: GM and INV Factors in Subclasses of Human IgG , J Exp Med 122:1087-1102, 1965.Crossref 20. Stiehm, E.R., and Fudenberg, H.H.: Antibodies to γ-Globulin in Infants and Children Exposed to Isologous γGlobulin , Pediatrics 35:229-235, 1965. 21. Utsumi, S., and Karush, F.: Peptic Fragmentation of Rabbit γG-Immunoglobulin , Biochemistry 4:1776-1779, 1965.Crossref 22. Ishizaka, K., and Ishizaka, T.: Molecular Basis of Passive Sensitization: II. The Role of Fragment III of γGlobulin and Its Disulfide Bond in Passive Sensitization and Complement Fixation , J Immun 93:59-68, 1964. 23. Amiraian, K., and Leikhim, E.J.: Properties of Fragments of Human Wassermann Antibodies , Immunology 10:349-353, 1966. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Intravenous Administration of Modified Gamma Globulin: Several Studies on a Patient With Agammaglobulinemia

Archives of Internal Medicine , Volume 119 (1) – Jan 1, 1967

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Publisher
American Medical Association
Copyright
Copyright © 1967 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1967.00290190108008
Publisher site
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Abstract

Abstract Persons injected intravenously with human γ-globulin may develop symptoms which include anxiety, flushing of the face, a constricting feeling in the chest, muscle pain in the trunk or thighs, nausea and vomiting, fever, and rarely collapse.1-3 In one study seven of 54 subjects receiving 110 ml of 1.5% γ-globulin solution intravenously experienced a reaction.1 However, readministration, if within 72 hours, was well tolerated even by those who previously had reacted unfavorably. Individual susceptibility as well as rate of infusion, total amount given and perhaps the specific γ-globulin preparation may be determinants in the frequency and severity of symptoms. Peculiarly, the incidence of systemic reactions was extremely high in those with antibody deficiency syndromes such as primary agammaglobulinemia.1,4 By contrast, pepsin treated preparations of γ-globulin elicited few or no symptoms when given to people with a variety of diseases including agammaglobulinemia.5-7 The present report describes symptoms and laboratory findings observed during References 1. Barandun, S., et al: Intravenous Administration of Human γ-Globulin , Vox Sang 7:157-174, 1962.Crossref 2. Moore, G.E.; Sandberg, A.; and Amos, D.B.: Experimental and Clinical Adventures With Large Doses of Gamma and Other Globulins as Anticancer Agents , Surgery 41:972-983, 1957. 3. Coon, W.W., et al: Experiences With Large Infusions of γ-Globulin , Amer J Surg 102:548-553, 1961.Crossref 4. Hitzig, W.H., and Willi, H.: Hereditäre lymphoplasmocytäre Dysgenesie ("Alymphocytose mit Agammaglobulinämie") , Schweiz Med Wschr 91: 1625-1633, 1961. 5. Schultze, H.E., and Schwick, G.: Über neue Möglichkeiten intravenöser γ-globulin-Applikation , Deutsch Med Wschr 87:1643-1650, 1962.Crossref 6. Lang, W.: Die intravenöse γ-Globulin-Therapie , Deutsch Med Wschr 89:2374-2379, 1964.Crossref 7. Koch, F.: Erste Erfahrungen mit Gamma-VeninR, einem intravenös injizierbaren Gamma-globulin-Präparat, in der Kinderheilkunde , Deutsch Med Wschr 88:282-285, 1963.Crossref 8. Cohen, S.: Nomenclature of Human Immunoglobulins, editorial , Immunology 8:1-5, 1965. 9. Glaser, J., and Wyss-Souffront, W.A.: Alleged Anaphylactic Reactions to Human γ-Globulin , Pediatrics 28:367-376, 1961. 10. Squire, J.R.: Immunoglobulins , Proc Roy Soc Med 57:749-752, 1964. 11. Richerson, H.B., and Seebohm, P.M.: Anaphylactoid Reaction to Human γGlobulin , Arch Intern Med 117:568-572, 1966.Crossref 12. Richter, M., et al: Effects of Physicochemical Agents on the Electrophoretic Properties of Serum Proteins in Starch Gel Medium , Canad J Biochem 40:35-39, 1962.Crossref 13. Christian, C.L.: Studies on Aggregated γ-Globulin: I. Sedimentation, Electrophoretic, and Anticomplementary Properties , J Immun 84:112-116, 1960. 14. Christian, C.L.: Studies on Aggregated γ-Globulin: II. Effect in Vivo , J Immun 84:117-121, 1960. 15. Ishizaka, K.; Ishizaka, T.; and Sugahara, T.: Biologic Activity of Aggregated γGlobulin: III. Production of Arthus-like Reactions , J Immun 86: 220-227, 1961. 16. Benacerraf, B.; Sebestyen, M.; and Cooper, N.S.: The Clearance of Antigen Antibody Complexes from the Blood by the Reticulo-endothelial System , J Immun 82:131-137, 1959. 17. Barandun, S.; Kaiser, M.; and Dostal, V.: Zur Frage der intravenösen γGlobulin-Applikation , Helv Med Acta 28:551-555, 1961. 18. Tomasi, T.B., Jr.: Human γGlobulin Analytical Review , Blood 25:382-403, 1965. 19. Terry, W.D.; Fahey, J.L.; and Steinberg, A.G.: GM and INV Factors in Subclasses of Human IgG , J Exp Med 122:1087-1102, 1965.Crossref 20. Stiehm, E.R., and Fudenberg, H.H.: Antibodies to γ-Globulin in Infants and Children Exposed to Isologous γGlobulin , Pediatrics 35:229-235, 1965. 21. Utsumi, S., and Karush, F.: Peptic Fragmentation of Rabbit γG-Immunoglobulin , Biochemistry 4:1776-1779, 1965.Crossref 22. Ishizaka, K., and Ishizaka, T.: Molecular Basis of Passive Sensitization: II. The Role of Fragment III of γGlobulin and Its Disulfide Bond in Passive Sensitization and Complement Fixation , J Immun 93:59-68, 1964. 23. Amiraian, K., and Leikhim, E.J.: Properties of Fragments of Human Wassermann Antibodies , Immunology 10:349-353, 1966.

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Jan 1, 1967

References