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Intrasinusoidal Metastatic Melanoma of the Liver With Reactive Hepatitis: An Immunologic Phenomenon?

Intrasinusoidal Metastatic Melanoma of the Liver With Reactive Hepatitis: An Immunologic Phenomenon? Abstract • The macrophage migration inhibition factor (MIF) test toward extracts of choroidal melanoma was repeated four times in a patient with ocular malignant melanoma. In the initial stage, when there was only an ocular finding, the MIF test result was positive. It remained so for a period of two years, even when intrasinusoidal hepatic diffusion developed concomitantly with a nonspecific reactive hepatitis. These histologic findings can be interpreted as evidence of the presence of an immune reaction at a particular moment in the disease process. Several months later, when the patient's condition went into an abrupt decline and showed extensive nodular spread, the results of MIF test were found to have become negative. (Arch Intern Med 1983;143:363-365) References 1. Schuppel O: Zur lehre con der Histogenese des Leberkrebs. Arch Heilkude 1868;9:387-405. 2. Manor RS, Livni E, Joshua H, et al: Inhibition of macrophage migration by choroidal malignant melanoma-associated antigens in patients with uveal melanoma. Invest Ophthalmol Vis Sci 1978;17:684-687. 3. Delpre G, Grinblat J, Kadish U, et al: Immunological studies in a case of hepatitis following methyldopa administration. Am J Med Sci 1979;297: 207-213.Crossref 4. Rajapakse DA, Glynn LE: Macrophage migration inhibition test using guinea pig macrophages and human leucocytes. Nature 1970;226:857-858.Crossref 5. Nouel O, Bernuau J, Lebrec D, et al: Severe hepatic failure and portal hypertension due to metastatic carcinoma of the liver. Gastroenterol Clin Biol 1979;3:135-137. 6. Priest RJ, Berk JE: Metastatic and other tumors , in Bockus HL (ed): Gastroenterology . Philadelphia, WB Saunders Co, 1976, vol 3, pp 535-543. 7. Smith JC: Diffuse intrasinusoidal metastatic cancer of the liver. Ann Intern Med 1961;54:104-113.Crossref 8. Watson AJ: Diffuse intrasinusoidal metastatic carcinoma of the liver. J Pathol Bact 1965;69:207-217.Crossref 9. Poulsen H, Christoffersen P: Non-specific reactive hepatitis , in Atlas of Liver Biopsies . Copenhagen, Munksgaard, 1979, p 180-181. 10. Scheur PJ: The liver in systemic disease , in Liver Biopsy Interpretation . London, Baillière Tindall, 1974, pp 130-131. 11. MacSween RNM: Liver pathology associated with diseases of other organs , in MacSween RNM, Anthony PP, Scheur PJ (eds): Pathology of the Liver . New York, Churchill Livingstone, 1979, pp 414-415. 12. Popper H, Schaffner F: The Liver: Structure and Function . New York, McGraw-Hill Book Co, 1957. 13. Cracium EC, Aslan A, Caffee L: Cirrhose atrophique néoplastique secondaire. Ann Anat Pathol 1931;8:1089-1112. 14. Micolonghi T, Pineda E, Stanley M: Metastatic carcinomatous cirrhosis of the liver. Arch Pathol Lab Med 1958;65:56-62. 15. Oertel H: On a peculiar vascular transportation and generalization of carcinoma without local metastasis: A contribution to the knowledge of metastatic growth. J Pathol Bact 1935;40:323-324.Crossref 16. Trigler DR: The liver as an immunological organ. Gastroenterology 1976;71:162-164. 17. Vuitton D, Trepo C, Eloy R: The immune response and the liver. Gastroenterol Clin Biol 1977;1:799-820. 18. Davidson CS: The immune system and the liver , in MacSween RNM, Anthony PP, Scheur PH (eds): Pathology of the Liver . New York, Churchill Livingstone, 1979, pp 46-48. 19. Delpre G, Ilie B, Papo J, et al: Hypernephroma with non-metastatic liver dysfunction (Stauffer's syndrome) and hypercalcemia. Am J Gastroenterol 1979;72:239-247. 20. Sherlock S: The liver and diseases of the reticulo-endothelial system in Sherlock S (ed): Disease of the Liver and Biliary System . Oxford, England, Blackwell Scientific Publications, 1975, pp 587-607. 21. Roth JA, Slocum HK, Pellegrino MA, et al: Purification of soluble human melanoma-associated antigens. Cancer Res 1976;36:2360-2364. 22. Char DH, Hullinshead A, Cogan DC, et al: Cutaneous delayed hypersensitivity reactions to soluble melanoma antigen in patients with ocular malignant melanoma. N Engl J Med 1974;291:274-277.Crossref 23. Char DH, Jerome L, McCoy JL, et al: Cell-mediated immunity to melanoma-associated antigens in patients with ocular malignant melanoma. Am J Ophthalmol 1975;79:812-816. 24. Hellström I, Hellström KE, Sjogren HO, et al: Demonstration of cell-mediated immunity to human neoplasms of various histological types. Int J Cancer 1971;7:1-16.Crossref 25. Hellström KE, Hellström I: Cellular immunity against tumor antigens. Adv Cancer Res 1969;12:167-223. 26. David JRS, Al-Ashari HS, Lawrence HS: Delayed hypersensitivity in vitro: I. The specificity of inhibition of cell-migration by antigens. J Immunol 1964;93:264-273. 27. Chaparas SD, Thor E, Godfrey HP, et al: Tuberculin active carbohydrate that induces inhibition of macrophage migration but not lymphocyte transformation. Science 1970;170:637-639.Crossref 28. Rosenberg SA, David JR: Inhibition of leukocyte migration: An evaluation of this in vitro assay of delayed hypersensitivity in man to a soluble antigen. J Immunol 1970;105:1447-1452. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Intrasinusoidal Metastatic Melanoma of the Liver With Reactive Hepatitis: An Immunologic Phenomenon?

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Publisher
American Medical Association
Copyright
Copyright © 1983 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1983.00350020189037
Publisher site
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Abstract

Abstract • The macrophage migration inhibition factor (MIF) test toward extracts of choroidal melanoma was repeated four times in a patient with ocular malignant melanoma. In the initial stage, when there was only an ocular finding, the MIF test result was positive. It remained so for a period of two years, even when intrasinusoidal hepatic diffusion developed concomitantly with a nonspecific reactive hepatitis. These histologic findings can be interpreted as evidence of the presence of an immune reaction at a particular moment in the disease process. Several months later, when the patient's condition went into an abrupt decline and showed extensive nodular spread, the results of MIF test were found to have become negative. (Arch Intern Med 1983;143:363-365) References 1. Schuppel O: Zur lehre con der Histogenese des Leberkrebs. Arch Heilkude 1868;9:387-405. 2. Manor RS, Livni E, Joshua H, et al: Inhibition of macrophage migration by choroidal malignant melanoma-associated antigens in patients with uveal melanoma. Invest Ophthalmol Vis Sci 1978;17:684-687. 3. Delpre G, Grinblat J, Kadish U, et al: Immunological studies in a case of hepatitis following methyldopa administration. Am J Med Sci 1979;297: 207-213.Crossref 4. Rajapakse DA, Glynn LE: Macrophage migration inhibition test using guinea pig macrophages and human leucocytes. Nature 1970;226:857-858.Crossref 5. Nouel O, Bernuau J, Lebrec D, et al: Severe hepatic failure and portal hypertension due to metastatic carcinoma of the liver. Gastroenterol Clin Biol 1979;3:135-137. 6. Priest RJ, Berk JE: Metastatic and other tumors , in Bockus HL (ed): Gastroenterology . Philadelphia, WB Saunders Co, 1976, vol 3, pp 535-543. 7. Smith JC: Diffuse intrasinusoidal metastatic cancer of the liver. Ann Intern Med 1961;54:104-113.Crossref 8. Watson AJ: Diffuse intrasinusoidal metastatic carcinoma of the liver. J Pathol Bact 1965;69:207-217.Crossref 9. Poulsen H, Christoffersen P: Non-specific reactive hepatitis , in Atlas of Liver Biopsies . Copenhagen, Munksgaard, 1979, p 180-181. 10. Scheur PJ: The liver in systemic disease , in Liver Biopsy Interpretation . London, Baillière Tindall, 1974, pp 130-131. 11. MacSween RNM: Liver pathology associated with diseases of other organs , in MacSween RNM, Anthony PP, Scheur PJ (eds): Pathology of the Liver . New York, Churchill Livingstone, 1979, pp 414-415. 12. Popper H, Schaffner F: The Liver: Structure and Function . New York, McGraw-Hill Book Co, 1957. 13. Cracium EC, Aslan A, Caffee L: Cirrhose atrophique néoplastique secondaire. Ann Anat Pathol 1931;8:1089-1112. 14. Micolonghi T, Pineda E, Stanley M: Metastatic carcinomatous cirrhosis of the liver. Arch Pathol Lab Med 1958;65:56-62. 15. Oertel H: On a peculiar vascular transportation and generalization of carcinoma without local metastasis: A contribution to the knowledge of metastatic growth. J Pathol Bact 1935;40:323-324.Crossref 16. Trigler DR: The liver as an immunological organ. Gastroenterology 1976;71:162-164. 17. Vuitton D, Trepo C, Eloy R: The immune response and the liver. Gastroenterol Clin Biol 1977;1:799-820. 18. Davidson CS: The immune system and the liver , in MacSween RNM, Anthony PP, Scheur PH (eds): Pathology of the Liver . New York, Churchill Livingstone, 1979, pp 46-48. 19. Delpre G, Ilie B, Papo J, et al: Hypernephroma with non-metastatic liver dysfunction (Stauffer's syndrome) and hypercalcemia. Am J Gastroenterol 1979;72:239-247. 20. Sherlock S: The liver and diseases of the reticulo-endothelial system in Sherlock S (ed): Disease of the Liver and Biliary System . Oxford, England, Blackwell Scientific Publications, 1975, pp 587-607. 21. Roth JA, Slocum HK, Pellegrino MA, et al: Purification of soluble human melanoma-associated antigens. Cancer Res 1976;36:2360-2364. 22. Char DH, Hullinshead A, Cogan DC, et al: Cutaneous delayed hypersensitivity reactions to soluble melanoma antigen in patients with ocular malignant melanoma. N Engl J Med 1974;291:274-277.Crossref 23. Char DH, Jerome L, McCoy JL, et al: Cell-mediated immunity to melanoma-associated antigens in patients with ocular malignant melanoma. Am J Ophthalmol 1975;79:812-816. 24. Hellström I, Hellström KE, Sjogren HO, et al: Demonstration of cell-mediated immunity to human neoplasms of various histological types. Int J Cancer 1971;7:1-16.Crossref 25. Hellström KE, Hellström I: Cellular immunity against tumor antigens. Adv Cancer Res 1969;12:167-223. 26. David JRS, Al-Ashari HS, Lawrence HS: Delayed hypersensitivity in vitro: I. The specificity of inhibition of cell-migration by antigens. J Immunol 1964;93:264-273. 27. Chaparas SD, Thor E, Godfrey HP, et al: Tuberculin active carbohydrate that induces inhibition of macrophage migration but not lymphocyte transformation. Science 1970;170:637-639.Crossref 28. Rosenberg SA, David JR: Inhibition of leukocyte migration: An evaluation of this in vitro assay of delayed hypersensitivity in man to a soluble antigen. J Immunol 1970;105:1447-1452.

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Feb 1, 1983

References