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Intraocular Pressure and Blood Flow Through the Uvea

Intraocular Pressure and Blood Flow Through the Uvea Abstract There is evidence for interrelationships between uveal blood flow, aqueous formation, intraocular pressure, and venous pressure counteracting aqueous drainage. It can therefore be expected that the relationship between intraocular pressure and blood flow through the uvea should be complicated. The purpose of the present investigation was to study part of the latter relationship, namely, the changes in uveal blood flow produced by changes in intraocular pressure. This problem was studied earlier by Sondermann,30 and other investigators have reported about the influence of the intraocular pressure on the blood flow through the choroid. The findings were rather conflicting. Sondermann,30 working with rabbits, found no constant relationship between the intraocular pressure and the flow from an opened vortex vein but reported that as a rule an increase in intraocular pressure gave a decrease in blood flow. Bornschein and Zwieauer,12 using a dye injection technique in rabbits, found evidence for References 1. Emulgon ( Farm. Revy 48:569, 1949) 2. Bean, J. W., and Wagemaker, H.: Brain Blood Flow, Chlorpromazine (Thorazine) and Its Protective Action Against the Toxicity of O2 at High Pressure , Amer. J. Physiol. 198:341, 1960. 3. Becker, B.: The Effect of Hypothermia on Aqueous Humor Dynamics , Amer. J. Ophthal. 51:1032 (May, (Pt. 2) ), 1961. 4. Bill, A.: Methods for Quantitative Determination of Uveal Blood Flow in Rabbits, with a Note on the Regulation of the Uveal Venous Pressure, to be published. 5. Bill, A.: Aspects of the Regulation of the Uveal Venous Pressure in Rabbits, to be published. 6. Bill, A.: To be published. 7. Bill, A.: Calorimetric Procedure for the Study of the Blood Flow Through the Ciliary Region and the Choroid in Rabbits, with a Note on the Relationship Between the Local Blood Flow and the Intraocular Pressure, to be published. 8. Bill, A.: Studies of the Heated Thermocouple Principle for Determinations of Blood Flow in Tissues, Acta Physiol. Scand., to be published. 9. Bill, A.: The Drainage of Blood from the Uvea and the Elimination of Aqueous Humor in Rabbits, to be published. 10. Bill, A.: A Method for Quantitative Determination of the Blood Flow Through the Cat Uvea, Arch Ophthal., to be published. 11. Bill, A.: Aspects of the Drainage of Aqueous Humor in Cats, Arch. Ophthal., to be published. 12. Bill, A.: To be published. 13. Bornschein, H., and Zwieauer, A.: Untersuchungen über die Aderhautdurchblutung bei experimenteller Erhöhung des intraocularen Druckes , Graefe. Arch. Ophthal. 150:661, 1950.Crossref 14. Burton, A. C.: On the Physical Equilibrium of Small Blood Vessels , Amer. J. Physiol. 164:319, 1951. 15. Enghoff, H.: Quantitative Hämoglobinbestimmungen und Erytrozytenuntersuchungen, Uppsala Universitets Årsskrift 1937. 16. Ericson, L. A.: Twenty-Four Hourly Variations of the Aqueous Flow , Acta Ophthal. (Kbh.) (Suppl. 50) , 1958. 17. Folkow, B., and Löfving, B.: The Distensibility of the Systemic Resistance Blood Vessels , Acta Physiol. Scand. 38:37, 1956.Crossref 18. Gibbs, F. A.: A Thermoelectric Blood Flow Recorder in the Form of a Needle , Proc. Soc. Exp. Biol. Med. 31:141, 1933.Crossref 19. Girling, F.: Vasomotor Effects of Electrical Stumulation , Amer. J. Physiol. 170:131, 1952. 20. Grayson, J.: Internal Calorimetry in the Determination of Thermal Conductivity and Blood Flow , J. Physiol. (Lond.) 118:54, 1952. 21. Green, H. D., and Kepchar, J. H.: Control of Peripheral Resistance in Major Systemic Vascular Beds , Physiol. Rev. 39:617, 1959. 22. Green, H. D.: Physiologic Action of Ganglionic and Adrenergic Blocking Agents on Peripheral Circulation , Minnesota Med. 41:241, 1958. 23. Green, H. D.; Hall, L. S.; Sexton, J., and Deal, C. P.: Autonomic Vasomotor Responses in the Canine Hepatic Arterial and Venous Beds , Amer. J. Physiol. 196:196, 1959. 24. Langham, M. E.: Aqueous Humor and Control of Intraocular Pressure , Physiol. Rev. 38:215, 1958. 25. Leber, T.: Die Circulations- und Ernährungsverhältnisse des Auges , in Graefe-Saemisch: Handbuch der gesamten Augenheilkunde , Leipzig, W. Engelmann, 1903, Vol. 2, Pt. 2. 26. Linnér, E.: Ascorbic Acid as a Test Substance for Measuring Relative Changes in the Rate of Plasma Flow Through the Ciliary Process: I. The Effect of Unilateral Ligation of the Common Carotid Artery in Rabbits on the Ascorbic Acid Content of the Aqueous Humor at Varying Plasma Levels , Acta Physiol. Scand. 26:57, 1952.Crossref 27. Niesel, P., and Konstas, P.: Versuche zur Registrierung von Veränderungen der Aderhautdurchblutung bei Kaninchen , Ber. Ophthal. Ges. (Heidelberg) . 62:150, 1959. 28. Pollack, I. P.; Becker, B., and Constant, M. A.: The Effect of Hypothermia on Aqueous Humor Dynamics: 1. Intraocular Pressure and Outflow Facility of the Rabbit Eye , Amer. J. Ophthal. 49:1126 ( (Pt. 2) ), 1960. 29. Pollack, I. P., and Becker, B.: The Effect of Hypothermia on Aqueous Humor Dynamics , Amer. J. Ophthal. 51:1039, 1961. 30. Porsaa, K.: Experimental Studies on the Vasomotor Innervation of the Retinal Arteries , Acta Ophthal. (Kbh.) (Suppl. 18) , 1941. 31. Sondermann, R.: Experimentelle Untersuchungen über die Durchblutungsgrösse des Auges bei normalem und abnormalem Drucke , Arch. Augenheilk. 105:698, 1932. 32. Sokoloff, L., and Kety, S. S.: Regulation of Cerebral Circulation , Physiol. Rev. 40 ( (Suppl. 4) , Pt. 2) 38, 1960. 33. Wudka, E., and Leopold, I. H.: Experimental Studies of the Choroidal Vessels: IV. Pharmacologic Observations , A.M.A. Arch. Ophthal. 55:857, 1956.Crossref 34. Wudka, E., and Leopold, I. H.: Experimental Studies of the Choroidal Vessels: V. Hemodynamic Observations , A.M.A. Arch. Ophthal. 58:710, 1957.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Intraocular Pressure and Blood Flow Through the Uvea

BILL, ANDERS
Archives of Ophthalmology , Volume 67 (3) – Mar 1, 1962
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Publisher
American Medical Association
Copyright
Copyright © 1962 American Medical Association. All Rights Reserved.
ISSN
0003-9950
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1538-3687
DOI
10.1001/archopht.1962.00960020338010
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Abstract

Abstract There is evidence for interrelationships between uveal blood flow, aqueous formation, intraocular pressure, and venous pressure counteracting aqueous drainage. It can therefore be expected that the relationship between intraocular pressure and blood flow through the uvea should be complicated. The purpose of the present investigation was to study part of the latter relationship, namely, the changes in uveal blood flow produced by changes in intraocular pressure. This problem was studied earlier by Sondermann,30 and other investigators have reported about the influence of the intraocular pressure on the blood flow through the choroid. The findings were rather conflicting. Sondermann,30 working with rabbits, found no constant relationship between the intraocular pressure and the flow from an opened vortex vein but reported that as a rule an increase in intraocular pressure gave a decrease in blood flow. Bornschein and Zwieauer,12 using a dye injection technique in rabbits, found evidence for References 1. Emulgon ( Farm. Revy 48:569, 1949) 2. Bean, J. W., and Wagemaker, H.: Brain Blood Flow, Chlorpromazine (Thorazine) and Its Protective Action Against the Toxicity of O2 at High Pressure , Amer. J. Physiol. 198:341, 1960. 3. Becker, B.: The Effect of Hypothermia on Aqueous Humor Dynamics , Amer. J. Ophthal. 51:1032 (May, (Pt. 2) ), 1961. 4. Bill, A.: Methods for Quantitative Determination of Uveal Blood Flow in Rabbits, with a Note on the Regulation of the Uveal Venous Pressure, to be published. 5. Bill, A.: Aspects of the Regulation of the Uveal Venous Pressure in Rabbits, to be published. 6. Bill, A.: To be published. 7. Bill, A.: Calorimetric Procedure for the Study of the Blood Flow Through the Ciliary Region and the Choroid in Rabbits, with a Note on the Relationship Between the Local Blood Flow and the Intraocular Pressure, to be published. 8. Bill, A.: Studies of the Heated Thermocouple Principle for Determinations of Blood Flow in Tissues, Acta Physiol. Scand., to be published. 9. Bill, A.: The Drainage of Blood from the Uvea and the Elimination of Aqueous Humor in Rabbits, to be published. 10. Bill, A.: A Method for Quantitative Determination of the Blood Flow Through the Cat Uvea, Arch Ophthal., to be published. 11. Bill, A.: Aspects of the Drainage of Aqueous Humor in Cats, Arch. Ophthal., to be published. 12. Bill, A.: To be published. 13. Bornschein, H., and Zwieauer, A.: Untersuchungen über die Aderhautdurchblutung bei experimenteller Erhöhung des intraocularen Druckes , Graefe. Arch. Ophthal. 150:661, 1950.Crossref 14. Burton, A. C.: On the Physical Equilibrium of Small Blood Vessels , Amer. J. Physiol. 164:319, 1951. 15. Enghoff, H.: Quantitative Hämoglobinbestimmungen und Erytrozytenuntersuchungen, Uppsala Universitets Årsskrift 1937. 16. Ericson, L. A.: Twenty-Four Hourly Variations of the Aqueous Flow , Acta Ophthal. (Kbh.) (Suppl. 50) , 1958. 17. Folkow, B., and Löfving, B.: The Distensibility of the Systemic Resistance Blood Vessels , Acta Physiol. Scand. 38:37, 1956.Crossref 18. Gibbs, F. A.: A Thermoelectric Blood Flow Recorder in the Form of a Needle , Proc. Soc. Exp. Biol. Med. 31:141, 1933.Crossref 19. Girling, F.: Vasomotor Effects of Electrical Stumulation , Amer. J. Physiol. 170:131, 1952. 20. Grayson, J.: Internal Calorimetry in the Determination of Thermal Conductivity and Blood Flow , J. Physiol. (Lond.) 118:54, 1952. 21. Green, H. D., and Kepchar, J. H.: Control of Peripheral Resistance in Major Systemic Vascular Beds , Physiol. Rev. 39:617, 1959. 22. Green, H. D.: Physiologic Action of Ganglionic and Adrenergic Blocking Agents on Peripheral Circulation , Minnesota Med. 41:241, 1958. 23. Green, H. D.; Hall, L. S.; Sexton, J., and Deal, C. P.: Autonomic Vasomotor Responses in the Canine Hepatic Arterial and Venous Beds , Amer. J. Physiol. 196:196, 1959. 24. Langham, M. E.: Aqueous Humor and Control of Intraocular Pressure , Physiol. Rev. 38:215, 1958. 25. Leber, T.: Die Circulations- und Ernährungsverhältnisse des Auges , in Graefe-Saemisch: Handbuch der gesamten Augenheilkunde , Leipzig, W. Engelmann, 1903, Vol. 2, Pt. 2. 26. Linnér, E.: Ascorbic Acid as a Test Substance for Measuring Relative Changes in the Rate of Plasma Flow Through the Ciliary Process: I. The Effect of Unilateral Ligation of the Common Carotid Artery in Rabbits on the Ascorbic Acid Content of the Aqueous Humor at Varying Plasma Levels , Acta Physiol. Scand. 26:57, 1952.Crossref 27. Niesel, P., and Konstas, P.: Versuche zur Registrierung von Veränderungen der Aderhautdurchblutung bei Kaninchen , Ber. Ophthal. Ges. (Heidelberg) . 62:150, 1959. 28. Pollack, I. P.; Becker, B., and Constant, M. A.: The Effect of Hypothermia on Aqueous Humor Dynamics: 1. Intraocular Pressure and Outflow Facility of the Rabbit Eye , Amer. J. Ophthal. 49:1126 ( (Pt. 2) ), 1960. 29. Pollack, I. P., and Becker, B.: The Effect of Hypothermia on Aqueous Humor Dynamics , Amer. J. Ophthal. 51:1039, 1961. 30. Porsaa, K.: Experimental Studies on the Vasomotor Innervation of the Retinal Arteries , Acta Ophthal. (Kbh.) (Suppl. 18) , 1941. 31. Sondermann, R.: Experimentelle Untersuchungen über die Durchblutungsgrösse des Auges bei normalem und abnormalem Drucke , Arch. Augenheilk. 105:698, 1932. 32. Sokoloff, L., and Kety, S. S.: Regulation of Cerebral Circulation , Physiol. Rev. 40 ( (Suppl. 4) , Pt. 2) 38, 1960. 33. Wudka, E., and Leopold, I. H.: Experimental Studies of the Choroidal Vessels: IV. Pharmacologic Observations , A.M.A. Arch. Ophthal. 55:857, 1956.Crossref 34. Wudka, E., and Leopold, I. H.: Experimental Studies of the Choroidal Vessels: V. Hemodynamic Observations , A.M.A. Arch. Ophthal. 58:710, 1957.Crossref

Journal

Archives of Ophthalmology – American Medical Association

Published: Mar 1, 1962

References

  • Brain Blood Flow, Chlorpromazine (Thorazine) and Its Protective Action Against the Toxicity of O2 at High Pressure
    Bean , J. W., and Wagemaker, H.
  • The Effect of Hypothermia on Aqueous Humor Dynamics
    Becker , B.
  • Untersuchungen über die Aderhautdurchblutung bei experimenteller Erhöhung des intraocularen Druckes
    Bornschein , H., and Zwieauer, A.
  • On the Physical Equilibrium of Small Blood Vessels
    Burton , A. C.
  • Twenty-Four Hourly Variations of the Aqueous Flow
    Ericson , L. A.
  • The Distensibility of the Systemic Resistance Blood Vessels
    Folkow , B., and Löfving, B.
  • A Thermoelectric Blood Flow Recorder in the Form of a Needle
    Gibbs , F. A.
  • Vasomotor Effects of Electrical Stumulation
    Girling , F.
  • Internal Calorimetry in the Determination of Thermal Conductivity and Blood Flow
    Grayson , J.
  • Control of Peripheral Resistance in Major Systemic Vascular Beds
    Green , H. D., and Kepchar, J. H.
  • Physiologic Action of Ganglionic and Adrenergic Blocking Agents on Peripheral Circulation
    Green , H. D.
  • Autonomic Vasomotor Responses in the Canine Hepatic Arterial and Venous Beds
    Green , H. D.; Hall, L. S.; Sexton, J., and Deal, C. P.
  • Aqueous Humor and Control of Intraocular Pressure
    Langham , M. E.
  • Graefe-Saemisch: Handbuch der gesamten Augenheilkunde
    Leber , T.
  • Ascorbic Acid as a Test Substance for Measuring Relative Changes in the Rate of Plasma Flow Through the Ciliary Process: I. The Effect of Unilateral Ligation of the Common Carotid Artery in Rabbits on the Ascorbic Acid Content of the Aqueous Humor at Varying Plasma Levels
    Linnér , E.
  • Versuche zur Registrierung von Veränderungen der Aderhautdurchblutung bei Kaninchen
    Niesel , P., and Konstas, P.
  • The Effect of Hypothermia on Aqueous Humor Dynamics: 1. Intraocular Pressure and Outflow Facility of the Rabbit Eye
    Pollack , I. P.; Becker, B., and Constant, M. A.
  • The Effect of Hypothermia on Aqueous Humor Dynamics
    Pollack , I. P., and Becker, B.
  • Experimental Studies on the Vasomotor Innervation of the Retinal Arteries
    Porsaa , K.
  • Experimentelle Untersuchungen über die Durchblutungsgrösse des Auges bei normalem und abnormalem Drucke
    Sondermann , R.
  • Regulation of Cerebral Circulation
    Sokoloff , L., and Kety, S. S.
  • Experimental Studies of the Choroidal Vessels: IV. Pharmacologic Observations
    Wudka , E., and Leopold, I. H.
  • Experimental Studies of the Choroidal Vessels: V. Hemodynamic Observations
    Wudka , E., and Leopold, I. H.