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Intraocular Penetration of Sisomicin in Rabbits

Intraocular Penetration of Sisomicin in Rabbits Abstract • The intraocular penetration of sisomicin, an aminoglycoside antibiotic, was studied in 47 normal rabbits following subconjunctival and/or intramuscular (IM) injections. Sisomicin levels were determined in the cornea and the aqueous humor of the injected eye as well as in the aqueous of the fellow eye by means of the cylinder-plate bioassay technique. When the IM route alone was used, the eye tissue concentrations remained negligible. One hour after subconjunctival injection, highly therapeutic sisomicin concentrations were achieved in the aqueous humor of both injected and fellow eyes, but the level dropped to very low concentrations 12 hours after the injection. The concomitant administration of sisomicin intramuscularly and subconjunctivally resulted in a significant delay of the clearance of sisomicin from the eye tissues. The use of the combined subconjunctival IM regimen for administering aminoglycoside antibotics needs further evaluation. References 1. Stewart D, Bodey G: In vitro activity of sisomicin, an aminoglycoside antibiotic, against clinical isolates . J Antibiot 28:149-155, 1975.Crossref 2. Klastersky J, Myamubeya B, Vandenborre L: Antimicrobial effectiveness of kanamycin, aminosidin, B.B.—K 8, sisomicin, gentamicin and tobramycin combined with carbenicillin or cephalothin against Gram-negative rods . J Med Microbiol 7:465-472, 1974.Crossref 3. Devand M, Kayser F, Huber U: Resistance of bacteria to the newer aminoglycoside antibiotics: An epidemiological and enzymatic study . J Antibiot 30:655-664, 1977.Crossref 4. Waitz J, Moss E, Drube C, et al: Comparative activity of sisomicin, gentamicin, kanamycin, and tobramycin . Antimicrob Agents Chemother 2:431-437, 1972.Crossref 5. Stone H, Kolb L, Geheber C, et al: Use of aminoglycosides in surgical infections . Ann Surg 183:660-666, 1976.Crossref 6. Henriksson P, Svenningsen N, Kahlmeter G, et al: Sisomicin treatment of serious neonatal infections: A clinical and pharmacokinetic study . Acta Paediatr Scand 66:317-322, 1977.Crossref 7. Madson P, Kjaer T, Mosegaard A: Treatment of complicated urinary tract infections: Comparative study of sisomicin and gentamicin . Urology 9:635-638, 1977.Crossref 8. Uwaydah M, Faris B: Penetration of tobramycin sulfate in the aqueous humor of the rabbit . Arch Ophthalmol 94:1173-1174, 1976.Crossref 9. Golden B, Coppel S: Ocular tissue absorption of gentamicin . Arch Ophthalmol 84:792-796, 1970.Crossref 10. Petonnis A, Papapanons G, Makromihelaki CK: Penetration of tobramycin sulphate into the human eye . Br J Ophthalmol 62:660-662, 1978.Crossref 11. Kuming B, Tonkin M: Use of gentamicin sulphate in ophthalmology . Br J Ophthalmol 58:609-612, 1974.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

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Publisher
American Medical Association
Copyright
Copyright © 1980 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1980.01020040902023
Publisher site
See Article on Publisher Site

Abstract

Abstract • The intraocular penetration of sisomicin, an aminoglycoside antibiotic, was studied in 47 normal rabbits following subconjunctival and/or intramuscular (IM) injections. Sisomicin levels were determined in the cornea and the aqueous humor of the injected eye as well as in the aqueous of the fellow eye by means of the cylinder-plate bioassay technique. When the IM route alone was used, the eye tissue concentrations remained negligible. One hour after subconjunctival injection, highly therapeutic sisomicin concentrations were achieved in the aqueous humor of both injected and fellow eyes, but the level dropped to very low concentrations 12 hours after the injection. The concomitant administration of sisomicin intramuscularly and subconjunctivally resulted in a significant delay of the clearance of sisomicin from the eye tissues. The use of the combined subconjunctival IM regimen for administering aminoglycoside antibotics needs further evaluation. References 1. Stewart D, Bodey G: In vitro activity of sisomicin, an aminoglycoside antibiotic, against clinical isolates . J Antibiot 28:149-155, 1975.Crossref 2. Klastersky J, Myamubeya B, Vandenborre L: Antimicrobial effectiveness of kanamycin, aminosidin, B.B.—K 8, sisomicin, gentamicin and tobramycin combined with carbenicillin or cephalothin against Gram-negative rods . J Med Microbiol 7:465-472, 1974.Crossref 3. Devand M, Kayser F, Huber U: Resistance of bacteria to the newer aminoglycoside antibiotics: An epidemiological and enzymatic study . J Antibiot 30:655-664, 1977.Crossref 4. Waitz J, Moss E, Drube C, et al: Comparative activity of sisomicin, gentamicin, kanamycin, and tobramycin . Antimicrob Agents Chemother 2:431-437, 1972.Crossref 5. Stone H, Kolb L, Geheber C, et al: Use of aminoglycosides in surgical infections . Ann Surg 183:660-666, 1976.Crossref 6. Henriksson P, Svenningsen N, Kahlmeter G, et al: Sisomicin treatment of serious neonatal infections: A clinical and pharmacokinetic study . Acta Paediatr Scand 66:317-322, 1977.Crossref 7. Madson P, Kjaer T, Mosegaard A: Treatment of complicated urinary tract infections: Comparative study of sisomicin and gentamicin . Urology 9:635-638, 1977.Crossref 8. Uwaydah M, Faris B: Penetration of tobramycin sulfate in the aqueous humor of the rabbit . Arch Ophthalmol 94:1173-1174, 1976.Crossref 9. Golden B, Coppel S: Ocular tissue absorption of gentamicin . Arch Ophthalmol 84:792-796, 1970.Crossref 10. Petonnis A, Papapanons G, Makromihelaki CK: Penetration of tobramycin sulphate into the human eye . Br J Ophthalmol 62:660-662, 1978.Crossref 11. Kuming B, Tonkin M: Use of gentamicin sulphate in ophthalmology . Br J Ophthalmol 58:609-612, 1974.Crossref

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Nov 1, 1980

References

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