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Intraocular Penetration of Colistin

Intraocular Penetration of Colistin Abstract Introduction Colistin is a new antibiotic isolated in Japan from the microorganism Aerobacillus colistinus.1 It is very similar to the polymyxins in its chemical composition, and in its spectrum of activity closely resembles polymyxin B. It is highly inhibitory for many gram-negative organisms and only slightly inhibitory or inactive towards grampositive organisms. Colistin is of distinct value in the treatment of localized and generalized infections caused by Pseudomonas aeruginosa, an organism proved to be resistant to the majority of other antibiotic and chemotherapeutic agents. Its spectrum of activity also includes Escherichia coli, Aerobacter aerogenes, Klebsiella pneumoniae, and many strains of Salmonella and Shigella. It is not effective against Proteus bacilli. The activity of colistin is not impaired in the presence of serum, whole blood, or the body fluids.2Colistin is available from Warner-Chilcott Laboratories as Coly-Mycin Ophthalmic (colistin sulfate) for topical use for investigational purposes, and as Colistimethate References 1. Koyama, Y.; Kurosasa, A.; Tsuchiya, A., and Takakuta, K.: A New Antibiotic "Colistin" Produced by Spore-Forming Soil Bacteria , J. Antibiot. [A] 3:457 ( (June) ) 1950. 2. Wright, W., and Welch, H.: Chemical, Biological, and Clinical Observations on Colistin , Antibiotic. Ann. 7:61, 1959-1960. 3. Ross, S.; Puig, J. R., and Zaremba, E. A.: Colistin: Some Preliminary Laboratory and Clinical Observations in Specific Gastroenteritis in Infants and Children , Antibiotic. Ann. 7:89, 1959-1960. 4. Pryor, J. G.; Apt, L., and Leopold, I. H.: Intraocular Penetration of Vancomycin, this issue, page 608. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Intraocular Penetration of Colistin

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Publisher
American Medical Association
Copyright
Copyright © 1962 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1962.00960020612016
Publisher site
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Abstract

Abstract Introduction Colistin is a new antibiotic isolated in Japan from the microorganism Aerobacillus colistinus.1 It is very similar to the polymyxins in its chemical composition, and in its spectrum of activity closely resembles polymyxin B. It is highly inhibitory for many gram-negative organisms and only slightly inhibitory or inactive towards grampositive organisms. Colistin is of distinct value in the treatment of localized and generalized infections caused by Pseudomonas aeruginosa, an organism proved to be resistant to the majority of other antibiotic and chemotherapeutic agents. Its spectrum of activity also includes Escherichia coli, Aerobacter aerogenes, Klebsiella pneumoniae, and many strains of Salmonella and Shigella. It is not effective against Proteus bacilli. The activity of colistin is not impaired in the presence of serum, whole blood, or the body fluids.2Colistin is available from Warner-Chilcott Laboratories as Coly-Mycin Ophthalmic (colistin sulfate) for topical use for investigational purposes, and as Colistimethate References 1. Koyama, Y.; Kurosasa, A.; Tsuchiya, A., and Takakuta, K.: A New Antibiotic "Colistin" Produced by Spore-Forming Soil Bacteria , J. Antibiot. [A] 3:457 ( (June) ) 1950. 2. Wright, W., and Welch, H.: Chemical, Biological, and Clinical Observations on Colistin , Antibiotic. Ann. 7:61, 1959-1960. 3. Ross, S.; Puig, J. R., and Zaremba, E. A.: Colistin: Some Preliminary Laboratory and Clinical Observations in Specific Gastroenteritis in Infants and Children , Antibiotic. Ann. 7:89, 1959-1960. 4. Pryor, J. G.; Apt, L., and Leopold, I. H.: Intraocular Penetration of Vancomycin, this issue, page 608.

Journal

Archives of Ophthalmology – American Medical Association

Published: May 1, 1962

References

  • A New Antibiotic "Colistin" Produced by Spore-Forming Soil Bacteria
    Koyama , Y.; Kurosasa, A.; Tsuchiya, A., and Takakuta, K.
  • Chemical, Biological, and Clinical Observations on Colistin
    Wright , W., and Welch, H.
  • Colistin: Some Preliminary Laboratory and Clinical Observations in Specific Gastroenteritis in Infants and Children
    Ross , S.; Puig, J. R., and Zaremba, E. A.