THE CUTTING EDGE SECTION EDITOR: GEORGE J. HRUZA, MD; ASSISTANT SECTION EDITORS: LYNN A. CORNELIUS, MD; JOHN STARR, MD Intralesional Cisplatin for the Treatment of Cutaneous B-Cell Lymphoma Werner Kempf, MD; Reinhardn Dummer, MD; Monika Hess Schmid, MD; Tanja Fritz, MD; Brunello Wu ¨ thrich, MD; Guenter Burg, MD; Department of Dermatology, Zurich University Hospital, Zurich, Switzerland The Cutting Edge: Challenges in Medical and Surgical Therapeutics REPORT OF A CASE A 56-year-old white woman presented with a solid ery- thematous nodule on her scalp that had developed 6 years earlier. She denied having a fever, losing weight, or sweat- ing during the night. Her medical history was notable for epilepsy, which was adequately controlled with phenothi- azine and chlorpromazine therapy. When a solitary nod- ule first appeared on the patient’s head 6 years earlier, a biopsy specimen revealed nodular, dense B-cell infiltrates without blasts, nuclear atypias, or mitoses. Therefore, the lesion had been regarded clinically and histologically as a B-cell pseudolymphoma. The patient was subsequently treated with potent topical corticosteroid creams and lo- cal psoralen–UV-A, but within 2 years the preexisting nod- ule became larger and 2 further nodules appeared despite the therapy. After topical chemotherapy using carbomus- tine
JAMA Dermatology – American Medical Association
Published: Nov 1, 1998
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