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Intralesional Bleomycin Sulfate Therapy for Warts: A Novel Bifurcated Needle Puncture Technique

Intralesional Bleomycin Sulfate Therapy for Warts: A Novel Bifurcated Needle Puncture Technique Abstract • A multiple puncture technique using a bifurcated vaccination needle to introduce bleomycin sulfate (1 U/mL sterile saline solution) into warts resulted in elimination of 92% of a random series of 258 warts after a single treatment. Recurrence was not observed during a 6-month follow-up period. Six of the 66 patients required two to seven treatments for wart eradication, and four patients requested alternative therapy after initial failure with a single bleomycin treatment. (Arch Dermatol. 1991;127:234-236) References 1. Bunney MH. Viral Warts: Their Biology and Treatment . New York, NY: Oxford University Press Inc; 1982. 2. Belisario JC. Warts and their treatment . Australas J Dermatol. 1951;1:20-30.Crossref 3. Beutner KR, Conant MA, Friedman-Kien AE, et al. Patient-applied podofilox for the treatment of genital warts . Lancet . 1989;1:831-834.Crossref 4. Lasser AE, Glazer SD. Vehicle effects on comparative irritancy and patient compliance in topical wart therapy . Curr Ther Res. 1986;39:1011-1016. 5. McCarthy JT. Warts . Cutis. 1986;38:87. 6. Fenner F, Henderson DA, Arita I, Jezek Z, Ladnyi ID. Smallpox and Its Eradication . Geneva, Switzerland; World Health Organization; 1988:567-574. 7. Hayes ME, O'Keefe EJ. Reduced dose of bleomycin in the treatment of recalcitrant warts . J Am Acad Dermatol. 1986;15:1002-1006.Crossref 8. Mishima Y, Matunaka M. Effect of bleomycin on benign and malignant cutaneous tumours . Acta Derm Venereol (Stockh) . 1971;52:211-215. 9. Bennett JM, Reich SD. Bleomycin . Ann Intern Med. 1979;90:945-948.Crossref 10. Bremner RM. Warts: treatment with intralesional bleomycin . Cutis. 1976;18:264-266. 11. Shumack PH, Haddock MJ. Bleomycin: an effective treatment for warts . Australas J Dermatol. 1979;20:41-42.Crossref 12. Takigawa M, Oku T, Ginoza M, Yamada M, Yamamoto T, Kobayashi I. Treatment of viral warts with pressure-sensitive adhesive tape containing bleomycin sulfate . Arch Dermatol. 1985;121:1108.Crossref 13. Laffitte F, Chavoin JP, Bonafe JL, Costagliola M. Under heel foot wart . Dermatologica. 1985;171:206-208.Crossref 14. Zaias N. The Nail in Health and Disease . 2nd ed. East Norwalk, Conn: Appleton & Lange; 1990:216-217. 15. Epstein E. Persisting Raynaud's phenomenon following intralesional bleomycin treatment of finger warts . J Am Acad Dermatol. 1985;13: 468-469.Crossref 16. Smith EA, Harper FE, LeRoy EC. Raynaud's phenomenon of a single digit following local intradermal bleomycin sulfate injection . Arthritis Rheum. 1985;28:459-461.Crossref 17. Miller RAW. Nail dystrophy following intralesional injections of bleomycin for a periungual wart . Arch Dermatol. 1984;120:963-964.Crossref 18. González FU, Gil MCC, Martinez AA, Rodriquez PG, de Paz FS, García-Pérez A. Cutaneous toxicity of intralesional bleomycin administration in the treatment of periungual warts . Arch Dermatol. 1986;122:974-975.Crossref 19. Bunney MH. Intralesional bleomycin sulfate in treatment of recalcitrant warts . Clin Dermatol. 1985;3:189-194.Crossref 20. Sayama S, Tagami H. Treatment of keratoacanthoma with intralesional bleomycin . Br J Dermatol. 1983;109:449-452.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Intralesional Bleomycin Sulfate Therapy for Warts: A Novel Bifurcated Needle Puncture Technique

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Publisher
American Medical Association
Copyright
Copyright © 1991 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1991.01680020102014
Publisher site
See Article on Publisher Site

Abstract

Abstract • A multiple puncture technique using a bifurcated vaccination needle to introduce bleomycin sulfate (1 U/mL sterile saline solution) into warts resulted in elimination of 92% of a random series of 258 warts after a single treatment. Recurrence was not observed during a 6-month follow-up period. Six of the 66 patients required two to seven treatments for wart eradication, and four patients requested alternative therapy after initial failure with a single bleomycin treatment. (Arch Dermatol. 1991;127:234-236) References 1. Bunney MH. Viral Warts: Their Biology and Treatment . New York, NY: Oxford University Press Inc; 1982. 2. Belisario JC. Warts and their treatment . Australas J Dermatol. 1951;1:20-30.Crossref 3. Beutner KR, Conant MA, Friedman-Kien AE, et al. Patient-applied podofilox for the treatment of genital warts . Lancet . 1989;1:831-834.Crossref 4. Lasser AE, Glazer SD. Vehicle effects on comparative irritancy and patient compliance in topical wart therapy . Curr Ther Res. 1986;39:1011-1016. 5. McCarthy JT. Warts . Cutis. 1986;38:87. 6. Fenner F, Henderson DA, Arita I, Jezek Z, Ladnyi ID. Smallpox and Its Eradication . Geneva, Switzerland; World Health Organization; 1988:567-574. 7. Hayes ME, O'Keefe EJ. Reduced dose of bleomycin in the treatment of recalcitrant warts . J Am Acad Dermatol. 1986;15:1002-1006.Crossref 8. Mishima Y, Matunaka M. Effect of bleomycin on benign and malignant cutaneous tumours . Acta Derm Venereol (Stockh) . 1971;52:211-215. 9. Bennett JM, Reich SD. Bleomycin . Ann Intern Med. 1979;90:945-948.Crossref 10. Bremner RM. Warts: treatment with intralesional bleomycin . Cutis. 1976;18:264-266. 11. Shumack PH, Haddock MJ. Bleomycin: an effective treatment for warts . Australas J Dermatol. 1979;20:41-42.Crossref 12. Takigawa M, Oku T, Ginoza M, Yamada M, Yamamoto T, Kobayashi I. Treatment of viral warts with pressure-sensitive adhesive tape containing bleomycin sulfate . Arch Dermatol. 1985;121:1108.Crossref 13. Laffitte F, Chavoin JP, Bonafe JL, Costagliola M. Under heel foot wart . Dermatologica. 1985;171:206-208.Crossref 14. Zaias N. The Nail in Health and Disease . 2nd ed. East Norwalk, Conn: Appleton & Lange; 1990:216-217. 15. Epstein E. Persisting Raynaud's phenomenon following intralesional bleomycin treatment of finger warts . J Am Acad Dermatol. 1985;13: 468-469.Crossref 16. Smith EA, Harper FE, LeRoy EC. Raynaud's phenomenon of a single digit following local intradermal bleomycin sulfate injection . Arthritis Rheum. 1985;28:459-461.Crossref 17. Miller RAW. Nail dystrophy following intralesional injections of bleomycin for a periungual wart . Arch Dermatol. 1984;120:963-964.Crossref 18. González FU, Gil MCC, Martinez AA, Rodriquez PG, de Paz FS, García-Pérez A. Cutaneous toxicity of intralesional bleomycin administration in the treatment of periungual warts . Arch Dermatol. 1986;122:974-975.Crossref 19. Bunney MH. Intralesional bleomycin sulfate in treatment of recalcitrant warts . Clin Dermatol. 1985;3:189-194.Crossref 20. Sayama S, Tagami H. Treatment of keratoacanthoma with intralesional bleomycin . Br J Dermatol. 1983;109:449-452.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: Feb 1, 1991

References