Abstract An increase in the number of intraepithelial (IE) lymphocytes is a well-known characteristic of the jejunal lesion in patients with untreated celiac disease.1.2 A prolonged glutenfree diet results in a return to normal villous structure and reduction to normal of the IE lymphocyte count.3 After reintroduction of gluten, for some weeks and months the number of IE lymphocytes significantly increases in association with villous atrophy.4.5 We have previously reported that in 46 children with untreated celiac disease, a close inverse correlation exists between the IE lymphocyte count and the blood xylose value.6 In the present study, we wanted to see whether the IE lymphocyte count increased after a short exposure to gluten and before marked alteration in the villous pattern. We made counts of IE lymphocytes before and after a brief gluten challenge in 22 children with proved celiac disease who were aged between 3 years References 1. Ferguson A: Lymphocytes in coeliac disease , in Hekkens WThJM, Penna AS (eds): Proceedings of the Second International Coeliac Symposium . Leiden, the Netherlands, HE Stenford Kroese, 1974, p 265. 2. Ferguson A, McClure JP, Townley RRW: Investigations of the numbers and functions of small intestinal lymphocytes in children with diarrhoea . Acta Paediatr Scand 1976;65:541-546.Crossref 3. Rolles CJ, Anderson ChM, McNeish AS: Confirming persistence of gluten intolerance in children diagnosed as having coeliac disease in infancy . Arch Dis Child 1975;50:259-263.Crossref 4. Hamilton JR, McNeill LK: Childhood celiac disease: Response of treated patients to a small uniform daily dose of wheat gluten . J Pediatr 1972;81:885-893.Crossref 5. Mavromichalis J, Brueton MJ, McNeish AS, et al: Evaluation of the intraepithelial lymphocyte count in the jejunum in childhood enteropathies . Gut 1976;17:600-603.Crossref 6. Schaad U, Hadorn B, Gaze H: Intraepithelial lymphocytes and one-hour blood xylose in children with untreated coeliac disease . Lancet 1977;1:1264-1265.Crossref 7. Schaad U, Gaze H, Hadorn B, et al: Der Blutxylosetest im Kindesalter: Korrelation des 1-Stunden-Blutxylosewertes mit der Anzahl intraepithelial gelegener Lymphozyten in der Dünndarmschleimhaut bei der Zöliakie . Helv Paediatr Acta 1975;30:331-341.
American Journal of Diseases of Children – American Medical Association
Published: Mar 1, 1981
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