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INTRADERMAL VACCINATIONS WITH B C G VIRUS

INTRADERMAL VACCINATIONS WITH B C G VIRUS The antituberculosis vaccine of Calmette, known as B C G, consists of a strain of bovine tubercle bacilli, originally virulent, which, through long cultivation on bile-containing mediums, has lost its pathogenicity for animals and man. According to the original statement of Calmette,1 advocated for a long time, this organism should be absolutely avirulent, and should lack the power to produce any specific tissue changes. Injected into, or ingested by, laboratory animals, the B C G should be absorbed and carried to the regional lymphatic glands, where it should enter into a sort of symbiosis with the cells, and call forth no demonstrable tissue reaction. Control experiments, first reported by Kraus2 of Vienna, have shown, however, that the statement concerning the avirulence of the B C G was not quite true, being subject to some modification. A typical, but benign, spontaneously healing, tuberculosis does result from its inoculation into http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

INTRADERMAL VACCINATIONS WITH B C G VIRUS

WALLGREN, ARVID
JAMA , Volume 91 (24) – Dec 15, 1928
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References (1)

Publisher
American Medical Association
Copyright
Copyright © 1928 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.1928.02700240030008
Publisher site
See Article on Publisher Site

Abstract

The antituberculosis vaccine of Calmette, known as B C G, consists of a strain of bovine tubercle bacilli, originally virulent, which, through long cultivation on bile-containing mediums, has lost its pathogenicity for animals and man. According to the original statement of Calmette,1 advocated for a long time, this organism should be absolutely avirulent, and should lack the power to produce any specific tissue changes. Injected into, or ingested by, laboratory animals, the B C G should be absorbed and carried to the regional lymphatic glands, where it should enter into a sort of symbiosis with the cells, and call forth no demonstrable tissue reaction. Control experiments, first reported by Kraus2 of Vienna, have shown, however, that the statement concerning the avirulence of the B C G was not quite true, being subject to some modification. A typical, but benign, spontaneously healing, tuberculosis does result from its inoculation into

Journal

JAMA – American Medical Association

Published: Dec 15, 1928

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