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INTRADERMAL IMMUNIZATION

INTRADERMAL IMMUNIZATION Many attempts have been made to immunize against typhoid fever by methods other than the usual subcutaneous administration of vaccine. Thus Moor and Brown1 and Crimm and Short2 reported that vaccination by the oral route gave rise to concentrations of agglutinins in the blood serum which were as high as those obtained by the subcutaneous method. Downs and Bond,3 however, found that administration of typhoid vaccine by the oral route produced agglutinins in lower titers than those produced by subcutaneous injections. In a previous report4 we showed the efficacy of intradermal immunization against scarlet fever. In 1932 Tuft and his associates5 recommended intradermal immunization against typhoid fever. Siler and Dunham6 found that revaccination against typhoid fever by intracutaneous injection produced a satisfactory immunologic response. Tuft7 recently showed, by means of mouse protection tests, that vaccination by the intradermal method produced a satisfactory increase http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American journal of diseases of children American Medical Association

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References (7)

Publisher
American Medical Association
Copyright
Copyright © 1941 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0096-8994
eISSN
1538-3628
DOI
10.1001/archpedi.1941.02000170027002
Publisher site
See Article on Publisher Site

Abstract

Many attempts have been made to immunize against typhoid fever by methods other than the usual subcutaneous administration of vaccine. Thus Moor and Brown1 and Crimm and Short2 reported that vaccination by the oral route gave rise to concentrations of agglutinins in the blood serum which were as high as those obtained by the subcutaneous method. Downs and Bond,3 however, found that administration of typhoid vaccine by the oral route produced agglutinins in lower titers than those produced by subcutaneous injections. In a previous report4 we showed the efficacy of intradermal immunization against scarlet fever. In 1932 Tuft and his associates5 recommended intradermal immunization against typhoid fever. Siler and Dunham6 found that revaccination against typhoid fever by intracutaneous injection produced a satisfactory immunologic response. Tuft7 recently showed, by means of mouse protection tests, that vaccination by the intradermal method produced a satisfactory increase

Journal

American journal of diseases of childrenAmerican Medical Association

Published: Nov 1, 1941

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