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INTERMITTENT PERITONEAL LAVAGE IN NEPHRECTOMIZED DOGS AND ITS APPLICATION TO THE HUMAN BEING

INTERMITTENT PERITONEAL LAVAGE IN NEPHRECTOMIZED DOGS AND ITS APPLICATION TO THE HUMAN BEING Abstract PREVIOUS studies on the use of artificial measures (the artificial kidney, exchange blood transfusions, peritoneal lavage, etc.) to maintain life in the absence of renal function have been carried out chiefly on the human patient. Thus, a total of 101 patients have been treated by continuous peritoneal lavage,1 but the value of the method remains equivocal because many patients with acute anuria recover spontaneously when treated by more conservative measures.2 It was deemed necessary, therefore, to carry out studies on the nephrectomized animal in order to establish the potentialities of the method before proceeding to its application to the human patient. The present paper describes procedures for performing peritoneal lavage, by means of which it has been possible to maintain bilaterally nephrectomized dogs for periods of 30 to 70 days, which is several times that ever reported previously. With consideration of the inevitable malignant hypertension that develops following References 1. O'Dell, H. M.; Ferris, D. O., and Power, M. H.: Peritoneal Lavage as an Effective Means of Extrarenal Extraction , Am. J. Med. 9:63, 1950.Crossref 2. Muirhead, E. E.; Vanatta, J., and Grollman, A.: Acute Renal Insufficiency: A Comparison of the Use of an Artificial Kidney, Peritoneal Lavage and More Conservative Measures in Its Management , Arch. Int. Med. 83:528 ( (May) ) 1949.Crossref 3. Grollman, A.; Muirhead, E. E., and Vanatta, J.: Role of the Kidney in Pathogenesis of Hypertension as Determined by a Study of the Effects of Bilateral Nephrectomy and Other Experimental Procedures on the Blood Pressure of the Dog , Am. J. Physiol. 157:21, 1949. 4. Vanatta, J.; Muirhead, E. E., and Grollman, A.: Improvements of the Artificial Kidney: An Experimental Study of Its Application to Dogs Bilaterally Nephrectomized or Otherwise Deprived of Renal Function , Am. J. Physiol. 156:443, 1949. 5. Seligman, A. M.; Frank, H. A., and Fine, J.: Treatment of Experimental Uremia by Means of Peritoneal Irrigation , J. Clin. Investigation 25:211, 1946.Crossref 6. Abbott, W. E., and Shea, P.: The Treatment of Temporary Renal Insufficiency by Peritoneal Lavage , Am. J. M. Sc. 211:312, 1946.Crossref 7. Bliss, S.; Kastler, A. O., and Nadler, S. B.: Peritoneal Lavage: Effective Elimination of the Nitrogenous Waste in the Absence of Kidney Function , Proc. Soc. Exper. Biol. & Med. 29:1078, 1932. 8. Grollman and others.3 9. Vanatta and others.4 10. Butler, A. M., and Tuthill, E.: An Application of the Uranyl Zinc Acetate Method for Determination of Sodium in Biological Material , J. Biol. Chem. 93:171, 1931. 11. Stiff, H. A.: The Colorimetric Determination of Blood Chloride by the Iodometric Method , J. Biol. Chem. 172:695, 1948. 12. Van Slyke, D. D., and Cullen, G. E.: Studies of Acidosis: I. The Bicarbonate Concentration of the Blood Plasma; Its Significance, and Its Determination as a Measure of Acidosis , J. Biol. Chem. 30:289, 1917. 13. Looney, J. M., and Dyer, C. G.: Photoelectric Method for Determination of Potassium in Blood Serum , J. Lab. & Clin. Med. 28:355, 1942. 14. Clark, E. P., and Collip, J. B.: A Study of the Tisdall Method for the Determination of Blood Serum Calcium with a Suggested Modification , J. Biol. Chem. 63:461, 1925. 15. Hawk, P. B.; Oser, B. L., and Summerson, W. H.: Practical Physiological Chemistry , ed. 12, Philadelphia, The Blakiston Company, 1947. 16. Folin, O., and Wu, H.: A System of Blood Analysis , J. Biol. Chem. 38:81, 1919. 17. Fiske, C. H., and SubbaRow, J.: The Colorimetric Determination of Phosphorus , J. Biol. Chem. 66:375, 1925. 18. Letonoff, T. V., and Reinhold, J. G.: A Colorimetric Method for the Determination of Inorganic Sulfate in Serum and Urine , J. Biol. Chem. 114:147, 1936. 19. Theis, R. C., and Benedict, S. R.: The Determination of Phenols in the Blood , J. Biol. Chem. 61:67, 1924. 20. Fine, J.; Frank, H. A., and Seligman, A. M.: Treatment of Acute Renal Failure by Peritoneal Irrigation , Ann. Surg. 124:857, 1946. 21. Bull, G. M.; Joekes, A. M., and Lowe, K. G.: Conservative Treatment of Anuric Uraemia , Lancet 2:229, 1949. 22. Grollman, A.: The Vapour Pressures of Aqueous Solutions with Special Reference to the Problem of the State of Water in Biological Fluids , J. Gen. Physiol. 14:661, 1931. 23. Muirhead, E. E.: Grollman, A., and Vanatta, J.: Hypertensive Cardiovascular Disease ("Malignant Hypertension"): Changes in Canine Tissues Induced by Various Manipulations of the Kidney, with Special Reference to Vascular and Myocardial Lesions , Arch. Path. 50:137 ( (Aug.) ) 1950. 24. Grollman, A.: Experimental Studies on Hypertension, in Symposium on Hypertension, Minneapolis, University of Minnesota, to be published. 25. Seligman and others.5 26. Abbott and Shea.6 27. Bliss and others.7 28. Merrill, J. P.; Thorn, G. W.; Walter, C. W.; Callahan, E. J., III, and Smith, L. H., Jr.: Use of the Artificial Kidney , J. Clin. Investigation 29:412, 1950.Crossref 29. Dausset, J.: Lower Nephron Nephrosis: Report of Treatment of 44 Patients by Repeated Replacement Transfusions , Arch. Int. Med. 85:416 ( (March) ) 1950.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Internal Medicine American Medical Association

INTERMITTENT PERITONEAL LAVAGE IN NEPHRECTOMIZED DOGS AND ITS APPLICATION TO THE HUMAN BEING

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Publisher
American Medical Association
Copyright
Copyright © 1951 American Medical Association. All Rights Reserved.
ISSN
0888-2479
DOI
10.1001/archinte.1951.03810030052005
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Abstract

Abstract PREVIOUS studies on the use of artificial measures (the artificial kidney, exchange blood transfusions, peritoneal lavage, etc.) to maintain life in the absence of renal function have been carried out chiefly on the human patient. Thus, a total of 101 patients have been treated by continuous peritoneal lavage,1 but the value of the method remains equivocal because many patients with acute anuria recover spontaneously when treated by more conservative measures.2 It was deemed necessary, therefore, to carry out studies on the nephrectomized animal in order to establish the potentialities of the method before proceeding to its application to the human patient. The present paper describes procedures for performing peritoneal lavage, by means of which it has been possible to maintain bilaterally nephrectomized dogs for periods of 30 to 70 days, which is several times that ever reported previously. With consideration of the inevitable malignant hypertension that develops following References 1. O'Dell, H. M.; Ferris, D. O., and Power, M. H.: Peritoneal Lavage as an Effective Means of Extrarenal Extraction , Am. J. Med. 9:63, 1950.Crossref 2. Muirhead, E. E.; Vanatta, J., and Grollman, A.: Acute Renal Insufficiency: A Comparison of the Use of an Artificial Kidney, Peritoneal Lavage and More Conservative Measures in Its Management , Arch. Int. Med. 83:528 ( (May) ) 1949.Crossref 3. Grollman, A.; Muirhead, E. E., and Vanatta, J.: Role of the Kidney in Pathogenesis of Hypertension as Determined by a Study of the Effects of Bilateral Nephrectomy and Other Experimental Procedures on the Blood Pressure of the Dog , Am. J. Physiol. 157:21, 1949. 4. Vanatta, J.; Muirhead, E. E., and Grollman, A.: Improvements of the Artificial Kidney: An Experimental Study of Its Application to Dogs Bilaterally Nephrectomized or Otherwise Deprived of Renal Function , Am. J. Physiol. 156:443, 1949. 5. Seligman, A. M.; Frank, H. A., and Fine, J.: Treatment of Experimental Uremia by Means of Peritoneal Irrigation , J. Clin. Investigation 25:211, 1946.Crossref 6. Abbott, W. E., and Shea, P.: The Treatment of Temporary Renal Insufficiency by Peritoneal Lavage , Am. J. M. Sc. 211:312, 1946.Crossref 7. Bliss, S.; Kastler, A. O., and Nadler, S. B.: Peritoneal Lavage: Effective Elimination of the Nitrogenous Waste in the Absence of Kidney Function , Proc. Soc. Exper. Biol. & Med. 29:1078, 1932. 8. Grollman and others.3 9. Vanatta and others.4 10. Butler, A. M., and Tuthill, E.: An Application of the Uranyl Zinc Acetate Method for Determination of Sodium in Biological Material , J. Biol. Chem. 93:171, 1931. 11. Stiff, H. A.: The Colorimetric Determination of Blood Chloride by the Iodometric Method , J. Biol. Chem. 172:695, 1948. 12. Van Slyke, D. D., and Cullen, G. E.: Studies of Acidosis: I. The Bicarbonate Concentration of the Blood Plasma; Its Significance, and Its Determination as a Measure of Acidosis , J. Biol. Chem. 30:289, 1917. 13. Looney, J. M., and Dyer, C. G.: Photoelectric Method for Determination of Potassium in Blood Serum , J. Lab. & Clin. Med. 28:355, 1942. 14. Clark, E. P., and Collip, J. B.: A Study of the Tisdall Method for the Determination of Blood Serum Calcium with a Suggested Modification , J. Biol. Chem. 63:461, 1925. 15. Hawk, P. B.; Oser, B. L., and Summerson, W. H.: Practical Physiological Chemistry , ed. 12, Philadelphia, The Blakiston Company, 1947. 16. Folin, O., and Wu, H.: A System of Blood Analysis , J. Biol. Chem. 38:81, 1919. 17. Fiske, C. H., and SubbaRow, J.: The Colorimetric Determination of Phosphorus , J. Biol. Chem. 66:375, 1925. 18. Letonoff, T. V., and Reinhold, J. G.: A Colorimetric Method for the Determination of Inorganic Sulfate in Serum and Urine , J. Biol. Chem. 114:147, 1936. 19. Theis, R. C., and Benedict, S. R.: The Determination of Phenols in the Blood , J. Biol. Chem. 61:67, 1924. 20. Fine, J.; Frank, H. A., and Seligman, A. M.: Treatment of Acute Renal Failure by Peritoneal Irrigation , Ann. Surg. 124:857, 1946. 21. Bull, G. M.; Joekes, A. M., and Lowe, K. G.: Conservative Treatment of Anuric Uraemia , Lancet 2:229, 1949. 22. Grollman, A.: The Vapour Pressures of Aqueous Solutions with Special Reference to the Problem of the State of Water in Biological Fluids , J. Gen. Physiol. 14:661, 1931. 23. Muirhead, E. E.: Grollman, A., and Vanatta, J.: Hypertensive Cardiovascular Disease ("Malignant Hypertension"): Changes in Canine Tissues Induced by Various Manipulations of the Kidney, with Special Reference to Vascular and Myocardial Lesions , Arch. Path. 50:137 ( (Aug.) ) 1950. 24. Grollman, A.: Experimental Studies on Hypertension, in Symposium on Hypertension, Minneapolis, University of Minnesota, to be published. 25. Seligman and others.5 26. Abbott and Shea.6 27. Bliss and others.7 28. Merrill, J. P.; Thorn, G. W.; Walter, C. W.; Callahan, E. J., III, and Smith, L. H., Jr.: Use of the Artificial Kidney , J. Clin. Investigation 29:412, 1950.Crossref 29. Dausset, J.: Lower Nephron Nephrosis: Report of Treatment of 44 Patients by Repeated Replacement Transfusions , Arch. Int. Med. 85:416 ( (March) ) 1950.Crossref

Journal

A.M.A. Archives of Internal MedicineAmerican Medical Association

Published: Mar 1, 1951

References