Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You and Your Team.

Learn More →

Interferon α-N1 in Respiratory Papillomatosis

Interferon α-N1 in Respiratory Papillomatosis This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables. Abstract Haskins K. Kashima, MD, Associate Professor, Department of Otolaryngology—Head and Neck Surgery, The Johns Hopkins Medical Institutions, Baltimore, representing the 12-institution Papilloma Study Group, reported that interferon α-N1 was found effective as an adjuvant to endoscopic excision in respiratory papillomatosis. The findings of the prospectively randomized six-month study were gathered from 56 patients, 28 of whom received interferon and 28 of whom received no interferon. The anatomic extent of disease was objectively scored in all patients at endoscopic operations performed at two-month intervals; the median scores showed a statistically significant improvement in patients receiving interferon. Improvement in disease severity occurred irrespective of age, sex, duration of disease, HPV-6 subtype, or the presence or absence of a tracheotomy. Toxicity was "tolerable" and the agent was considered safe. The investigators stated that a longer period of interferon administration may be needed for maximum improvement; some of the study patients are presently http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Otolaryngology - Head & Neck Surgery American Medical Association

Interferon α-N1 in Respiratory Papillomatosis

Interferon α-N1 in Respiratory Papillomatosis

Abstract

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables. Abstract Haskins K. Kashima, MD, Associate Professor, Department of Otolaryngology—Head and Neck Surgery, The Johns Hopkins Medical Institutions, Baltimore, representing the 12-institution Papilloma Study Group, reported that interferon α-N1 was found effective as an adjuvant to endoscopic excision in respiratory papillomatosis. The findings of the...
Loading next page...
 
/lp/american-medical-association/interferon-n1-in-respiratory-papillomatosis-jkD4AEcv0e
Publisher
American Medical Association
Copyright
Copyright © 1986 American Medical Association. All Rights Reserved.
ISSN
0886-4470
eISSN
1538-361X
DOI
10.1001/archotol.1986.03780010021004
Publisher site
See Article on Publisher Site

Abstract

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables. Abstract Haskins K. Kashima, MD, Associate Professor, Department of Otolaryngology—Head and Neck Surgery, The Johns Hopkins Medical Institutions, Baltimore, representing the 12-institution Papilloma Study Group, reported that interferon α-N1 was found effective as an adjuvant to endoscopic excision in respiratory papillomatosis. The findings of the prospectively randomized six-month study were gathered from 56 patients, 28 of whom received interferon and 28 of whom received no interferon. The anatomic extent of disease was objectively scored in all patients at endoscopic operations performed at two-month intervals; the median scores showed a statistically significant improvement in patients receiving interferon. Improvement in disease severity occurred irrespective of age, sex, duration of disease, HPV-6 subtype, or the presence or absence of a tracheotomy. Toxicity was "tolerable" and the agent was considered safe. The investigators stated that a longer period of interferon administration may be needed for maximum improvement; some of the study patients are presently

Journal

Archives of Otolaryngology - Head & Neck SurgeryAmerican Medical Association

Published: Jan 1, 1986

There are no references for this article.