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D. Livingston, M. Malangoni (1988)
Interferon-γ restores immune competence after hemorrhagic shockJournal of Surgical Research, 45
S. Koyama (1988)
[Clinical investigation of interferons in the preleukemic state (CML and MDS)].Gan to kagaku ryoho. Cancer & chemotherapy, 15 4 Pt 2-2
H. Broxmeyer, S. Cooper, B. Rubin, M. Taylor (1985)
The synergistic influence of human interferon-gamma and interferon-alpha on suppression of hematopoietic progenitor cells is additive with the enhanced sensitivity of these cells to inhibition by interferons at low oxygen tension in vitro.Journal of immunology, 135 4
D. Boraschi, S. Censini, A. Tagliabue (1984)
Interferon-gamma reduces macrophage-suppressive activity by inhibiting prostaglandin E2 release and inducing interleukin 1 production.Journal of immunology, 133 2
D. Livingston, S. Appel, S. Wellhausen, G. Sonnenfeld, H. Polk (1988)
Depressed interferon gamma production and monocyte HLA-DR expression after severe injury.Archives of surgery, 123 11
M. Hershman, H. Polk, J. Pietsch, R. Shields, S. Wellhausen, G. Sonnenfeld (1988)
Modulation of infection by gamma interferon treatment following traumaInfection and Immunity, 56
T. Ulich, J. Castillo, Kz Guo (1989)
In vivo hematologic effects of recombinant interleukin-6 on hematopoiesis and circulating numbers of RBCs and WBCs.Blood, 73 1
Gentile PS Livingston DH (1990)
Bone marrow failure following hemorrhagic shockCirc Shock, 30
V. Peterson, J. Hansbrough, C. Buerk, C. Rundus, S. Wallner, H. Smith, W. Robinson (1983)
Regulation of granulopoiesis following severe thermal injury.The Journal of trauma, 23 1
S. Mogensen, J. Virelizier (1987)
The interferon-macrophage alliance.Interferon, 8
G. Madonna, S. Vogel (1985)
Early endotoxin tolerance is associated with alterations in bone marrow-derived macrophage precursor pools.Journal of immunology, 135 6
A. Maluish, W. Urba, D. Longo, W. Overton, D. Coggin, E. Crisp, R. Williams, S. Sherwin, K. Gordon, R. Steis (1988)
The determination of an immunologically active dose of interferon-gamma in patients with melanoma.Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 6 3
E. Kedar, A. Rezai, J. Giorgi, R. Gale, R. Champlin, R. Mitsuyasu, J. Fahey (1988)
Immunomodulating effects in vitro of interleukin-2 and interferon-gamma on human blood and bone marrow mononuclear cells.Natural immunity and cell growth regulation, 7 1
A. Naldini, W. Fleischmann (1987)
In vivo myelosuppression by combination interferon treatment: antagonism of MuIFN-gamma and MuIFN-beta myelosuppressive effects.Journal of biological response modifiers, 6 5
H. Broxmeyer, Li Lu, E. Platzer, C. Feit, L. Juliano, B. Rubin (1983)
Comparative analysis of the influences of human gamma, alpha and beta interferons on human multipotential (CFU-GEMM), erythroid (BFU-E) and granulocyte-macrophage (CFU-GM) progenitor cells.Journal of immunology, 131 3
Narita M Koyama S (1988)
In vitro effects of interferon-alpha and interferongamma on hematopoietic progenitor cells in bone marrowActa Haematol Jpn, 51
R. Philip, L. Epstein (1986)
Tumour necrosis factor as immunomodulator and mediator of monocyte cytotoxicity induced by itself, γ-interferon and interleukin-1Nature, 323
D. Livingston, M. Malangoni (1989)
An experimental study of susceptibility to infection after hemorrhagic shock.Surgery, gynecology & obstetrics, 168 2
Polk HC Jr Hershman MJ (1988)
Modulation of infection following trauma by interferon-γ treatmentInfect Immun, 56
T. Ulich, J. Castillo, Songmei Yin (1990)
Tumor necrosis factor exerts dose-dependent effects on erythropoiesis and myelopoiesis in vivo.Experimental hematology, 18 4
D. Metcalf, G. Johnson, T. Mandel (1979)
Colony formation in agar by multipotential hemopoietic cellsJournal of Cellular Physiology, 98
Rubin BY Broxmeyer HE (1983)
The HLA-DR restricted action of T-lymphocyte subsets on modulation of release of acidic isoferritininhibitory activity from monocytes is mediated by alpha and gamma interferon, interleukin 1, and transferrinBlood, 62
E. Faist, A. Mewes, T. Strasser, A. Walz, S. Alkan, C. Baker, W. Ertel, G. Heberer (1988)
Alteration of Monocyte Function Following Major InjuryArchives of Surgery, 123
E. Raefsky, L. Platanias, N. Zoumbos, N. Young (1985)
Studies of interferon as a regulator of hematopoietic cell proliferation.Journal of immunology, 135 4
W. Piacibello, L. Lu, M. Wachter, B. Rubin, H. Broxmeyer (1985)
Release of granulocyte-macrophage colony stimulating factors from major histocompatibility complex class II antigen-positive monocytes is enhanced by human gamma interferon.Blood, 66 6
S. Vogel, E. Kaufman, Michele Tate, R. Neta (1988)
Recombinant interleukin-1 alpha and recombinant tumor necrosis factor alpha synergize in vivo to induce early endotoxin tolerance and associated hematopoietic changesInfection and Immunity, 56
W. Piacibello, L. Lu, D. Williams, M. Aglietta, B. Rubin, S. Cooper, M. Wachter, F. Gavosto, H. Broxmeyer (1986)
Human gamma interferon enhances release from phytohemagglutinin-stimulated T4+ lymphocytes of activities that stimulate colony formation by granulocyte-macrophage, erythroid, and multipotential progenitor cells.Blood, 68 6
R. Kurzrock, M. Talpaz, H. Kantarjian, R. Walters, S. Saks, J. Trujillo, J. Gutterman (1987)
Therapy of chronic myelogenous leukemia with recombinant interferon-gamma.Blood, 70 4
Koyama S (1988)
Clinical investigation of interferons in the preleukemic state (CML and MDS)Jpn J Cancer Chemother, 15
Abstract • Hemorrhagic shock has been demonstrated to alter the myelopoietic response to bacterial lipopolysaccharide. Interferongamma has been shown to improve the immune response following experimental shock and injury; however, its effect on myelopoiesis is controversial. This study was performed to determine whether treatment with interferon-gamma will improve the bone marrow response to lipopolysaccharide after hemorrhagic shock. Rats subjected to either shock or a sham procedure were allocated into three groups: (1) control rats received no further treatment; (2) lipopolysaccharide-treated rats received saline for 3 days and then were challenged with lipopolysaccharide to stimulate myelopoiesis; and (3) interferon-treated rats received interferon-gamma (7500 U subcutaneously 1 hour after shock and then every day for 3 days) and lipopolysaccharide as in group 2. Serum colony-stimulating factor levels were measured 6 hours and bone marrow white blood cell count and granulocyte-macrophage colony-forming units (CFU-GM) were measured 24 hours following lipopolysaccharide administration. In sham-treated rats, lipopolysaccharide increased CFU-GM 77% compared with controls. In contrast, treatment with lipopolysaccharide decreased CFU-GM 43% following shock. Treatment with interferon-gamma increased CFU-GM in all animals and reversed the decline in CFU-GM seen in shocked lipopolysaccharide-treated animals. Serum colony-stimulating factor levels were unaffected by either shock or interferon-gamma administration. These data demonstrate that interferon-gamma exerts a stimulatory effect on bone marrow following shock and restores the myelopoietic response to lipopolysaccharide. (Arch Surg. 1991;126:100-103) References 1. Mogensen SC, Vrelizer JL. The interferon-macrophage alliance . Interferon . 1987;8:55-84. 2. Faist E, Mewes A, Strasser T, et al. Alteration of monocyte function following major injury . Arch Surg . 1988;123:287-292.Crossref 3. Livingston DH, Appel SH, Wellhauser SR, Sonnenfeld GS. Depressed interferon-gamma production and monocyte HLA-DR expression after severe injury . Arch Surg . 1988;123:1309-1312.Crossref 4. Livingston DH, Malangoni MA. Interferon-gamma restores immune competence after hemorrhagic shock . J Surg Res . 1988;45:37-43.Crossref 5. Hershman MJ, Polk HC Jr, Pietsch JD, et al. Modulation of infection following trauma by interferon-γ treatment . Infect Immun . 1988;56:2412-2416. 6. Piacibello W, Lu L, Rubin B, Broxmeyer HE. Release of granulocytemacrophage colony stimulating factors from major histocompatibility complex class II antigen–positive monocytes is enhanced by human gamma interferon . Blood . 1985;66:1343-1351. 7. Piacibello W, Lu L, Williams D, et al. Human gamma interferon enhances release from phytohemagglutin-stimulated T4+ lymphocytes of activities that stimulate colony formation by granulocyte-macrophage, erythroid, and multipotential progenitor cells . Blood . 1986;68:1339-1347. 8. Phillip R, Epstein LB. Tumor necrosis factor as an immunomodulator and mediator of monocyte cytotoxicity induced by itself, gamma-interferon and interleukin 1 . Nature . 1986;323:86-89.Crossref 9. Boraschi D, Lensini S, Tagliasve A. Interferon-gamma reduces macrophage-suppressive activity by inhibiting prostaglandin E2 release and inducing interleukin 1 production . J Immunol . 1984;133:764-768. 10. Broxmeyer HE, Rubin BY, Juliano L, et al. The HLA-DR restricted action of T-lymphocyte subsets on modulation of release of acidic isoferritininhibitory activity from monocytes is mediated by alpha and gamma interferon, interleukin 1, and transferrin . Blood . 1983;62( (suppl 1) ):131a. 11. Koyama S. Clinical investigation of interferons in the preleukemic state (CML and MDS) . Jpn J Cancer Chemother . 1988;15:1191-1197. 12. Broxmeyer HE, Lu L, Platzer E, et al. Comparative analysis of the influences of human gamma, alpha and beta interferons on human multipotential (CFU-GEMM), erythroid (BFU-E) and granulocyte-macrophage (CFUGM) progenitor cells . J Immunol . 1983;131:1300-1305. 13. Broxmeyer HE, Cooper S, Rubin BY, Taylor MW. The synergistic influence of human interferon-gamma and interferon-alpha on suppression of hematopoietic progenitor cells is additive with the enhanced sensitivity of these cells to inhibition by interferons at low oxygen tension in vitro . J Immunol . 1985;135:2502-2506. 14. Koyama S, Narita M. In vitro effects of interferon-alpha and interferongamma on hematopoietic progenitor cells in bone marrow . Acta Haematol Jpn . 1988;51:1540-1549. 15. Raefsky EL, Platanias LC, Zoumbox NC, Young NS. Studies of interferon as a regulator of hematopoietic cell proliferation . J Immunol . 1985;135:2507-2512. 16. Naldini A, Fleischmann WR Jr. In vivo myelosuppression by combination interferon treatment: antagonism of MuIFN-gamma and MuIFN-beta myelosuppressive effects . J Biol Response Mod . 1987;6:546-555. 17. Kurzrock R, Talpaz M, Kantarjian H, et al. Therapy of chronic myelogenous leukemia with recombinant interferon-gamma . Blood . 1987;70:943-947. 18. Maluish AE, Urba WJ, Longo DL, et al. The determination of immunologically active dose of interferon gamma in patients with melanoma . J Clin Oncol . 1988;6:434-445. 19. Metcalf D, Johnson GR, Mandel TF. Colony formation in agar by multipotential hematopoietic cells . J Cell Physiol . 1979;98:401-411.Crossref 20. Livingston DH, Gentile PS, Malangoni MA. Bone marrow failure following hemorrhagic shock . Circ Shock . 1990;30:255-264. 21. Peterson V, Hansbrough J, Buerk C, et al. Regulation of granulopoiesis following severe thermal injury . J Trauma . 1983;23:19-24.Crossref 22. Livingston DH, Malangoni MA. An experimental study of susceptibility to infection after hemorrhagic shock . Surg Gynecol Obstet . 1988;168:138-142. 23. Vogel SN, Kaufman EN, Tate MD, Neta R. Recombinant interleukin 1 alpha and recombinant tumor necrosis factor alpha synergize in vivo to induce early endotoxin tolerance and associated hematopoietic changes . Infect Immunol . 1988;56:2650-2657. 24. Ulich TR, Castille JD, Yin S. Tumor necrosis factor exerts dose-dependent effects on erythropoiesis and myelopoiesis in vivo . Exp Hematol . 1990;18:311-315. 25. Madonna GS, Vogel SN. Early endotoxin tolerance is associated with alterations in bone marrow–derived macrophage precursor pools . J Immunol . 1985;135:3763-3771. 26. Ulich TR, Castillo JD, Guo K. In vivo hematologic effects of recombinant interleukin-6 on hematopoiesis and circulating numbers of RBCs and WBCs . Blood . 1989;73:108-110. 27. Kedar E, Reza AR, Giorgi JV, et al. Immunomodulating effects in vitro of interleukin-2 and interferon-gamma on human blood and bone marrow mononuclear cells . Nat Immun Cell Growth Regul . 1988;7:13-30.
Archives of Surgery – American Medical Association
Published: Jan 1, 1991
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