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K. Matsumoto, S. Miyake, M. Yano, Y. Ueki, A. Miyazaki, K. Hirao, Y. Tominaga (1999)
Insulin resistance and classic risk factors in type 2 diabetic patients with different subtypes of ischemic stroke.Diabetes care, 22 7
T Rundek, H Arif, B Boden-Albala, MS Elkind, MC Paik, RL Sacco (2008)
Carotid plaque, a subclinical precursor of vascular events: the Northern Manhattan Study., 70
H. Lakka, T. Lakka, J. Tuomilehto, J. Sivenius, J. Salonen (2000)
Hyperinsulinemia and the risk of cardiovascular death and acute coronary and cerebrovascular events in men: the Kuopio Ischaemic Heart Disease Risk Factor Study.Archives of internal medicine, 160 8
D. Matthews, J. Hosker, A. Rudenski, B. Naylor, D. Treacher, R. Turner (1985)
Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in manDiabetologia, 28
W. Kernan, Silvio Inzucchi, C. Viscoli, L. Brass, Dawn Bravata, Gerald Shulman, J. McVeety, R. Horwitz (2003)
Impaired insulin sensitivity among nondiabetic patients with a recent TIA or ischemic strokeNeurology, 60
(2001)
Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)., 285
B. Boden-Albala, S. Cammack, J. Chong, Culing Wang, C. Wright, T. Rundek, M. Elkind, M. Paik, R. Sacco (2008)
Diabetes, Fasting Glucose Levels, and Risk of Ischemic Stroke and Vascular EventsDiabetes Care, 31
A. Bertoni, N. Wong, S. Shea, Shuangge Ma, Kiang Liu, Srikanthan Preethi, D. Jacobs, C. Wu, M. Saad, M. Szklo (2007)
Insulin Resistance, Metabolic Syndrome, and Subclinical AtherosclerosisDiabetes Care, 30
W. Taylor, N. Unwin (2009)
Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) Detection, Evaluation, and Treatment of High Blood Cholesterol Education Program (NCEP) Expert Panel on Executive Summary of the Third Report of the National
D. Kargman, R. Sacco, B. Boden-Albala, M. Paik, W. Hauser, S. Shea (1999)
Validity of Telephone Interview Data for Vascular Disease Risk Factors in a Racially Mixed Urban Community: The Northern Manhattan Stroke StudyNeuroepidemiology, 18
H. White, B. Boden-Albala, Cuiling Wang, M. Elkind, T. Rundek, C. Wright, R. Sacco (2005)
Ischemic Stroke Subtype Incidence Among Whites, Blacks, and Hispanics: The Northern Manhattan StudyCirculation, 111
AG Bertoni, ND Wong, S Shea (2007)
Insulin resistance, metabolic syndrome, and subclinical atherosclerosis: the Multi-Ethnic Study of Atherosclerosis (MESA)., 30
T. Rundek, H. Arif, B. Boden-Albala, M. Elkind, M. Paik, R. Sacco (2008)
Carotid plaque, a subclinical precursor of vascular eventsNeurology, 70
A. Festa, R. D'Agostino, G. Howard, L. Mykkänen, R. Tracy, S. Haffner (2000)
Chronic subclinical inflammation as part of the insulin resistance syndrome: the Insulin Resistance Atherosclerosis Study (IRAS).Circulation, 102 1
S. Robins, D. Collins, J. Mcnamara, H. Bloomfield (2008)
Body weight, plasma insulin, and coronary events with gemfibrozil in the Veterans Affairs High-Density Lipoprotein Intervention Trial (VA-HIT).Atherosclerosis, 196 2
E. Bonora, S. Kiechl, J. Willeit, F. Oberhollenzer, G. Egger, J. Meigs, R. Bonadonna, M. Muggeo (2007)
Insulin Resistance as Estimated by Homeostasis Model Assessment Predicts Incident Symptomatic Cardiovascular Disease in Caucasian Subjects From the General PopulationDiabetes Care, 30
A. Bennet, K. Brismar, J. Hallqvist, C. Reuterwall, U. Faire (2002)
The risk of myocardial infarction is enhanced by a synergistic interaction between serum insulin and smoking.European journal of endocrinology, 147 5
D. Kendall, A. Harmel (2002)
The metabolic syndrome, type 2 diabetes, and cardiovascular disease: understanding the role of insulin resistance.The American journal of managed care, 8 20 Suppl
J. Stamler, O. Vaccaro, J. Neaton, D. Wentworth (1993)
Diabetes, Other Risk Factors, and 12-Yr Cardiovascular Mortality for Men Screened in the Multiple Risk Factor Intervention TrialDiabetes Care, 16
S. Haffner, H. Miettinen, M. Stern (1997)
The Homeostasis Model in the San Antonio Heart StudyDiabetes Care, 20
J. Jeppesen, T. Hansen, S. Rasmussen, H. Ibsen, C. Torp‐Pedersen, S. Madsbad (2007)
Insulin resistance, the metabolic syndrome, and risk of incident cardiovascular disease: a population-based study.Journal of the American College of Cardiology, 49 21
M. Pyörälä, H. Miettinen, M. Laakso, Kalevi rälä (1998)
Hyperinsulinemia and the risk of stroke in healthy middle-aged men: the 22-year follow-up results of the Helsinki Policemen Study.Stroke, 29 9
R. Sacco, B. Boden-Albala, G. Abel, I. Lin, Mitchell Elkind, W. Hauser, M. Paik, S. Shea (2001)
Race-Ethnic Disparities in the Impact of Stroke Risk Factors: The Northern Manhattan Stroke StudyStroke: Journal of the American Heart Association, 32
E. Blaak (2008)
Sex differences in the control of glucose homeostasisCurrent Opinion in Clinical Nutrition and Metabolic Care, 11
AR Folsom, ML Rasmussen, LE Chambless (1999)
Prospective associations of fasting insulin, body fat distribution, and diabetes with risk of ischemic stroke., 22
B. Boden-Albala, R. Sacco, H. Lee, C. Grahame-Clarke, T. Rundek, Mitchell Elkind, C. Wright, E. Giardina, M. DiTullio, S. Homma, M. Paik (2008)
Metabolic Syndrome and Ischemic Stroke Risk: Northern Manhattan StudyStroke, 39
H. Nishizawa, I. Shimomura, K. Kishida, N. Maeda, H. Kuriyama, H. Nagaretani, M. Matsuda, H. Kondo, N. Furuyama, S. Kihara, Tadashi Nakamura, Y. Tochino, T. Funahashi, Y. Matsuzawa (2002)
Androgens decrease plasma adiponectin, an insulin-sensitizing adipocyte-derived protein.Diabetes, 51 9
B Boden-Albala, S Cammack, J Chong (2008)
Diabetes, fasting glucose levels, and risk of ischemic stroke and vascular events: findings from the Northern Manhattan Study (NOMAS)., 31
C. Wang, H. Chen (2001)
Augmented Inverse Probability Weighted Estimator for Cox Missing Covariate RegressionBiometrics, 57
M. Rutter, P. Wilson, L. Sullivan, C. Fox, R. D'Agostino, J. Meigs (2008)
Use of Alternative Thresholds Defining Insulin Resistance to Predict Incident Type 2 Diabetes Mellitus and Cardiovascular DiseaseCirculation, 117
A. Folsom, Mandy Rasmussen, L. Chambless, George Howard, L. Cooper, M. Schmidt, G. Heiss (1999)
Prospective associations of fasting insulin, body fat distribution, and diabetes with risk of ischemic stroke. The Atherosclerosis Risk in Communities (ARIC) Study Investigators.Diabetes care, 22 7
E. Bonora, G. Targher, María Alberiche, R. Bonadonna, F. Saggiani, M. Zenere, T. Monauni, M. Muggeo (2000)
Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity: studies in subjects with various degrees of glucose tolerance and insulin sensitivity.Diabetes care, 23 1
ORIGINAL CONTRIBUTION Insulin Resistance and Risk of Ischemic Stroke Among Nondiabetic Individuals From the Northern Manhattan Study Tatjana Rundek, MD, PhD; Hannah Gardener, ScD; Qiang Xu, PhD; Ronald B. Goldberg, MD; Clinton B. Wright, MD, MS; Bernadette Boden-Albala, DrPH; Norbelina Disla, BS; Myunghee C. Paik, PhD; Mitchell S. V. Elkind, MD, MS; Ralph L. Sacco, MD, MS Background: Whether insulin resistance predicts is- myocardial infarction (MI), vascular death, and com- chemic stroke (IS) is still a matter of debate. bined outcomes (IS, MI, and vascular death). Objective: To determine the association between insu- Results: The mean (SD) HOMA-IR was 2.3 (2.1), and lin resistance (IR) and risk of first ischemic stroke in a large, Q4 was at least 2.8. During mean follow-up of 8.5 years, multiethnic, stroke-free cohort without diabetes. vascular events occurred in 180 participants; 46 had fa- tal or nonfatal IS, 45 had fatal or nonfatal MI, and 121 Design: Prospective, population-based cohort study. died of vascular causes. The HOMA-IR Q4 vs less than Q4 significantly predicted the risk of IS only (adjusted Setting: Longitudinal epidemiologic study. hazard ratio, 2.83; 95% confidence interval, 1.34-5.99) but not other vascular events. This effect was indepen- Participants: A cohort of
JAMA Neurology – American Medical Association
Published: Oct 1, 2010
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