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Insulin Resistance and Risk of Ischemic Stroke Among Nondiabetic Individuals From the Northern Manhattan Study

Insulin Resistance and Risk of Ischemic Stroke Among Nondiabetic Individuals From the Northern... ORIGINAL CONTRIBUTION Insulin Resistance and Risk of Ischemic Stroke Among Nondiabetic Individuals From the Northern Manhattan Study Tatjana Rundek, MD, PhD; Hannah Gardener, ScD; Qiang Xu, PhD; Ronald B. Goldberg, MD; Clinton B. Wright, MD, MS; Bernadette Boden-Albala, DrPH; Norbelina Disla, BS; Myunghee C. Paik, PhD; Mitchell S. V. Elkind, MD, MS; Ralph L. Sacco, MD, MS Background: Whether insulin resistance predicts is- myocardial infarction (MI), vascular death, and com- chemic stroke (IS) is still a matter of debate. bined outcomes (IS, MI, and vascular death). Objective: To determine the association between insu- Results: The mean (SD) HOMA-IR was 2.3 (2.1), and lin resistance (IR) and risk of first ischemic stroke in a large, Q4 was at least 2.8. During mean follow-up of 8.5 years, multiethnic, stroke-free cohort without diabetes. vascular events occurred in 180 participants; 46 had fa- tal or nonfatal IS, 45 had fatal or nonfatal MI, and 121 Design: Prospective, population-based cohort study. died of vascular causes. The HOMA-IR Q4 vs less than Q4 significantly predicted the risk of IS only (adjusted Setting: Longitudinal epidemiologic study. hazard ratio, 2.83; 95% confidence interval, 1.34-5.99) but not other vascular events. This effect was indepen- Participants: A cohort of http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Neurology American Medical Association

Insulin Resistance and Risk of Ischemic Stroke Among Nondiabetic Individuals From the Northern Manhattan Study

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References (32)

Publisher
American Medical Association
Copyright
Copyright 2010 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-6149
eISSN
2168-6157
DOI
10.1001/archneurol.2010.235
pmid
20937946
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL CONTRIBUTION Insulin Resistance and Risk of Ischemic Stroke Among Nondiabetic Individuals From the Northern Manhattan Study Tatjana Rundek, MD, PhD; Hannah Gardener, ScD; Qiang Xu, PhD; Ronald B. Goldberg, MD; Clinton B. Wright, MD, MS; Bernadette Boden-Albala, DrPH; Norbelina Disla, BS; Myunghee C. Paik, PhD; Mitchell S. V. Elkind, MD, MS; Ralph L. Sacco, MD, MS Background: Whether insulin resistance predicts is- myocardial infarction (MI), vascular death, and com- chemic stroke (IS) is still a matter of debate. bined outcomes (IS, MI, and vascular death). Objective: To determine the association between insu- Results: The mean (SD) HOMA-IR was 2.3 (2.1), and lin resistance (IR) and risk of first ischemic stroke in a large, Q4 was at least 2.8. During mean follow-up of 8.5 years, multiethnic, stroke-free cohort without diabetes. vascular events occurred in 180 participants; 46 had fa- tal or nonfatal IS, 45 had fatal or nonfatal MI, and 121 Design: Prospective, population-based cohort study. died of vascular causes. The HOMA-IR Q4 vs less than Q4 significantly predicted the risk of IS only (adjusted Setting: Longitudinal epidemiologic study. hazard ratio, 2.83; 95% confidence interval, 1.34-5.99) but not other vascular events. This effect was indepen- Participants: A cohort of

Journal

JAMA NeurologyAmerican Medical Association

Published: Oct 1, 2010

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