Abstract Patients suffering from diabetes mellitus are known to have periods during which they do not respond properly to insulin. It is likewise well established that diabetes becomes worse during infection, injury or operation. These observations have aroused much interest and investigation in the past few years. It is interesting that seventy-five years ago Claude Bernard1 was well aware of the danger of infection to diabetic patients. Patients who temporarily or permanently resist insulin action are called insulin resistant or insulin refractory. The periods of resistance to insulin may be recurrent, ending in spontaneous recovery, or may be lasting, terminating in coma and death. In July, 1925, E. K., a girl, aged 6 years, with severe diabetes, began to have peculiar reactions to insulin. On a constant diet and without any evident complication, she seemed to resist insulin action at one time and at another to have hypoglycemia on the same References 1. Bernard, Claude, quoted by Mauriac, P., and Aubertin, E.: Presse méd. 34:1633 ( (Dec.) ) 1926. 2. Kuttner, T.: Personal communication to the authors. The method is to be published. 3. Witzeman, E. J., and Livshis, L.: J. Biol. Chem. 58:463 ( (Sept.) ) 1923. 4. Shonle, H. H., and Waldo, J. H.: J. Biol. Chem. 66:467 ( (Dec.) ) 1925. 5. Epstein, A. A., and Rosenthal, N.: Am. J. Physiol. 70:225, 1924 6. 71: 316 (Jan.) 1925. 7. Loewi, O.: Klin. Wchnschr. 6:2169 ( (Nov. 12) ) 1927.Crossref 8. Collip, J. B.: Am. J. Physiol. 63:391, 1923. 9. Lundsgaard, C.; Holboll, S. A., and Gottschalk, A.: J. Biol. Chem. 70: 89 ( (Sept.) ) 1926. 10. Brugsch, T., and Horsters, H.: Med. Klin. 22:81 ( (Jan. 15) ) 1926. 11. Ahlgren, G.: Klin. Wchnschr. 3:1158 ( (June) ) 1924Crossref 12. 3:1222 (June) 1924.
Archives of Internal Medicine – American Medical Association
Published: Apr 1, 1930