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INSULIN INACTIVATION BY HUMAN BLOOD CELLS AND PLASMA IN VITRO: EFFECT OF NORMAL AND OF DIABETIC BLOOD ON INSULIN ACTION

INSULIN INACTIVATION BY HUMAN BLOOD CELLS AND PLASMA IN VITRO: EFFECT OF NORMAL AND OF DIABETIC... Abstract Patients suffering from diabetes mellitus are known to have periods during which they do not respond properly to insulin. It is likewise well established that diabetes becomes worse during infection, injury or operation. These observations have aroused much interest and investigation in the past few years. It is interesting that seventy-five years ago Claude Bernard1 was well aware of the danger of infection to diabetic patients. Patients who temporarily or permanently resist insulin action are called insulin resistant or insulin refractory. The periods of resistance to insulin may be recurrent, ending in spontaneous recovery, or may be lasting, terminating in coma and death. In July, 1925, E. K., a girl, aged 6 years, with severe diabetes, began to have peculiar reactions to insulin. On a constant diet and without any evident complication, she seemed to resist insulin action at one time and at another to have hypoglycemia on the same References 1. Bernard, Claude, quoted by Mauriac, P., and Aubertin, E.: Presse méd. 34:1633 ( (Dec.) ) 1926. 2. Kuttner, T.: Personal communication to the authors. The method is to be published. 3. Witzeman, E. J., and Livshis, L.: J. Biol. Chem. 58:463 ( (Sept.) ) 1923. 4. Shonle, H. H., and Waldo, J. H.: J. Biol. Chem. 66:467 ( (Dec.) ) 1925. 5. Epstein, A. A., and Rosenthal, N.: Am. J. Physiol. 70:225, 1924 6. 71: 316 (Jan.) 1925. 7. Loewi, O.: Klin. Wchnschr. 6:2169 ( (Nov. 12) ) 1927.Crossref 8. Collip, J. B.: Am. J. Physiol. 63:391, 1923. 9. Lundsgaard, C.; Holboll, S. A., and Gottschalk, A.: J. Biol. Chem. 70: 89 ( (Sept.) ) 1926. 10. Brugsch, T., and Horsters, H.: Med. Klin. 22:81 ( (Jan. 15) ) 1926. 11. Ahlgren, G.: Klin. Wchnschr. 3:1158 ( (June) ) 1924Crossref 12. 3:1222 (June) 1924. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

INSULIN INACTIVATION BY HUMAN BLOOD CELLS AND PLASMA IN VITRO: EFFECT OF NORMAL AND OF DIABETIC BLOOD ON INSULIN ACTION

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Publisher
American Medical Association
Copyright
Copyright © 1930 American Medical Association. All Rights Reserved.
ISSN
0730-188X
DOI
10.1001/archinte.1930.00140100068007
Publisher site
See Article on Publisher Site

Abstract

Abstract Patients suffering from diabetes mellitus are known to have periods during which they do not respond properly to insulin. It is likewise well established that diabetes becomes worse during infection, injury or operation. These observations have aroused much interest and investigation in the past few years. It is interesting that seventy-five years ago Claude Bernard1 was well aware of the danger of infection to diabetic patients. Patients who temporarily or permanently resist insulin action are called insulin resistant or insulin refractory. The periods of resistance to insulin may be recurrent, ending in spontaneous recovery, or may be lasting, terminating in coma and death. In July, 1925, E. K., a girl, aged 6 years, with severe diabetes, began to have peculiar reactions to insulin. On a constant diet and without any evident complication, she seemed to resist insulin action at one time and at another to have hypoglycemia on the same References 1. Bernard, Claude, quoted by Mauriac, P., and Aubertin, E.: Presse méd. 34:1633 ( (Dec.) ) 1926. 2. Kuttner, T.: Personal communication to the authors. The method is to be published. 3. Witzeman, E. J., and Livshis, L.: J. Biol. Chem. 58:463 ( (Sept.) ) 1923. 4. Shonle, H. H., and Waldo, J. H.: J. Biol. Chem. 66:467 ( (Dec.) ) 1925. 5. Epstein, A. A., and Rosenthal, N.: Am. J. Physiol. 70:225, 1924 6. 71: 316 (Jan.) 1925. 7. Loewi, O.: Klin. Wchnschr. 6:2169 ( (Nov. 12) ) 1927.Crossref 8. Collip, J. B.: Am. J. Physiol. 63:391, 1923. 9. Lundsgaard, C.; Holboll, S. A., and Gottschalk, A.: J. Biol. Chem. 70: 89 ( (Sept.) ) 1926. 10. Brugsch, T., and Horsters, H.: Med. Klin. 22:81 ( (Jan. 15) ) 1926. 11. Ahlgren, G.: Klin. Wchnschr. 3:1158 ( (June) ) 1924Crossref 12. 3:1222 (June) 1924.

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Apr 1, 1930

References