Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

INSULIN AND SUGAR TOLERANCE IN THIN PEOPLE

INSULIN AND SUGAR TOLERANCE IN THIN PEOPLE Abstract Comparatively little is known of the effect of insulin on sugar tolerance in nondiabetic persons. However, certain observations have been reported to suggest that the drug has an appreciable effect on this phase of metabolism. A temporary loss of carbohydrate tolerance during a period of administration of insulin was observed by Wilder, Smith and Sandiford1 in the case of two obese patients and by Paul, Clark and Gibson2 in five normal persons. Schellong and Kramer3 made tests for the sugar tolerance of fourteen thin women before and during insulin therapy and noted a more rapid rise and an earlier fall in the curves for blood sugar during the period of treatment with insulin than during the control period. Fricke4 administered dextrose by stomach tube to dogs without inducing glycosuria, but when the same dose of dextrose was combined with injections of insulin, glycosuria of short duration References 1. Wilder, R. M.; Smith, F. H., and Sandiford, I.: Observations on Obesity , Ann. Int. Med. 6:724, 1932.Crossref 2. Paul, W. D.; Clark, B. B., and Gibson, R. B.: Transient Hyperglycemia and Glycosuria Following Discontinuation of Insulin Given Nondiabetic Patients , Proc. Soc. Exper. Biol. & Med. 30:353, 1932. 3. Schellong, F., and Kramer, H.: Ueber die Ursachen der alimentären Hyperglykämie bei Kohlehydratkarenz (zugleich ein weiterer Beitrag zur Wirkungsweise der Insulin Mastkuren) , Klin. Wchnschr. 7:1726, 1928. 4. Fricke, G.: Glykosurie durch Insulin , Klin. Wchnschr. 5:1927, 1926. 5. Folin, O., and Malmros, H.: An Improved Form of Folin's Micro Method for Blood Sugar Determinations , J. Biol. Chem. 83:115, 1929. 6. Rabinowitch, I. M.: Observations on the Altered Renal Threshold for Sugar in Insulin—Treated Diabetics , Brit. J. Exper. Path. 7:352, 1926. 7. van Creveld, S., and van Dam, E.: De invloed van alcoholische pancreasextracten (Insule) op hat gedrag der nieren tegenover glucose , Nederl. tijschr. v. geneesk. 2:1498, 1923. 8. Blotner, H.: Observations on the Effect of Insulin in Thin Persons , J. A. M. A. 100:88 ( (Jan. 14) ) 1933. 9. Koref, O., and Mautner, H.: Zur Resorptionbeschleunigung durch Insulin , Klin. Wchnschr. 5:191, 1926. 10. Cori, C. F., and Cori, G. I.: The Fate of Sugar in the Animal Body , J. Biol. Chem. 76:763, 1928. 11. McJunkin, F. A., and Roberts, B. D.: Effect of Excessive Insulin on the Pancreatic Islets of Young Rats , Proc. Soc. Exper. Biol. & Med. 29:893, 1932. 12. Graber, H. T., and Cowles, R. A.: Effect of Corpus Luteum Extracts in Suppressing Ovarian Activity in Rats , Proc. Soc. Exper. Biol. & Med. 28:977, 1931. 13. Goldman, D., and Aub, J. C.: Personal communication to the author. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

INSULIN AND SUGAR TOLERANCE IN THIN PEOPLE

Archives of Internal Medicine , Volume 53 (1) – Jan 1, 1934

Loading next page...
 
/lp/american-medical-association/insulin-and-sugar-tolerance-in-thin-people-Xk0XCTZxfi
Publisher
American Medical Association
Copyright
Copyright © 1934 American Medical Association. All Rights Reserved.
ISSN
0730-188X
DOI
10.1001/archinte.1934.00160070158013
Publisher site
See Article on Publisher Site

Abstract

Abstract Comparatively little is known of the effect of insulin on sugar tolerance in nondiabetic persons. However, certain observations have been reported to suggest that the drug has an appreciable effect on this phase of metabolism. A temporary loss of carbohydrate tolerance during a period of administration of insulin was observed by Wilder, Smith and Sandiford1 in the case of two obese patients and by Paul, Clark and Gibson2 in five normal persons. Schellong and Kramer3 made tests for the sugar tolerance of fourteen thin women before and during insulin therapy and noted a more rapid rise and an earlier fall in the curves for blood sugar during the period of treatment with insulin than during the control period. Fricke4 administered dextrose by stomach tube to dogs without inducing glycosuria, but when the same dose of dextrose was combined with injections of insulin, glycosuria of short duration References 1. Wilder, R. M.; Smith, F. H., and Sandiford, I.: Observations on Obesity , Ann. Int. Med. 6:724, 1932.Crossref 2. Paul, W. D.; Clark, B. B., and Gibson, R. B.: Transient Hyperglycemia and Glycosuria Following Discontinuation of Insulin Given Nondiabetic Patients , Proc. Soc. Exper. Biol. & Med. 30:353, 1932. 3. Schellong, F., and Kramer, H.: Ueber die Ursachen der alimentären Hyperglykämie bei Kohlehydratkarenz (zugleich ein weiterer Beitrag zur Wirkungsweise der Insulin Mastkuren) , Klin. Wchnschr. 7:1726, 1928. 4. Fricke, G.: Glykosurie durch Insulin , Klin. Wchnschr. 5:1927, 1926. 5. Folin, O., and Malmros, H.: An Improved Form of Folin's Micro Method for Blood Sugar Determinations , J. Biol. Chem. 83:115, 1929. 6. Rabinowitch, I. M.: Observations on the Altered Renal Threshold for Sugar in Insulin—Treated Diabetics , Brit. J. Exper. Path. 7:352, 1926. 7. van Creveld, S., and van Dam, E.: De invloed van alcoholische pancreasextracten (Insule) op hat gedrag der nieren tegenover glucose , Nederl. tijschr. v. geneesk. 2:1498, 1923. 8. Blotner, H.: Observations on the Effect of Insulin in Thin Persons , J. A. M. A. 100:88 ( (Jan. 14) ) 1933. 9. Koref, O., and Mautner, H.: Zur Resorptionbeschleunigung durch Insulin , Klin. Wchnschr. 5:191, 1926. 10. Cori, C. F., and Cori, G. I.: The Fate of Sugar in the Animal Body , J. Biol. Chem. 76:763, 1928. 11. McJunkin, F. A., and Roberts, B. D.: Effect of Excessive Insulin on the Pancreatic Islets of Young Rats , Proc. Soc. Exper. Biol. & Med. 29:893, 1932. 12. Graber, H. T., and Cowles, R. A.: Effect of Corpus Luteum Extracts in Suppressing Ovarian Activity in Rats , Proc. Soc. Exper. Biol. & Med. 28:977, 1931. 13. Goldman, D., and Aub, J. C.: Personal communication to the author.

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Jan 1, 1934

References