Abstract • A totally implantable infusion pump (Infusaid) has been developed to achieve continuous drug delivery for long periods of time. The recent availability of a dualcatheter totally implantable infusion pump permits the infusion of both external carotid arteries simultaneously. This has obvious advantages for the treatment of extensive tumors of the head and neck that extend across the midline. Likewise, for the first time, unilateral local-regional disease that extends inferiorly beyond the nutrient field of the external carotid artery may be treated with intra-arterial infusion chemotherapy without the need to infuse the common carotid or innominate arteries. Unilateral infusion of the entire head and neck is accomplished by using the dual-catheter pump to infuse both the thyrocervical trunk and the external carotid artery. (Arch Otolaryngol 1982;108:703-708) References 1. Klopp CT, Alford TC, Bateman J, et al: Fractionated intra-arterial cancer chemotherapy with methylbis amino hydrochloride: Preliminary report . Ann Surg 1950;132:811-832.Crossref 2. Freckman HA: Results in 169 patients with cancer of the head and neck treated by intraarterial infusion therapy . Am J Surg 1972; 124:501-509.Crossref 3. Donegan WL, Harris HS: Factors influencing the success of arterial infusion chemotherapy for cancer of the head and neck . Am J Surg 1972;123:549-559.Crossref 4. Carter SK: The chemotherapy of head and neck cancer . Semin Oncol 1977;4:413-424. 5. Vogl SE, Kaplan BH: Chemotherapy of advanced head and neck cancer with methotrexate, bleomycin, and cis-diamminedichloroplatinum II in an effective outpatient schedule . Cancer 1979;44:26-31.Crossref 6. Wheeler RH, Liepman MK, Baker SR, et al: Bleomycin, vincristine, mitomycin C with or without methotrexate in the treatment of squamous cell carcinoma . Cancer Treat Rep 1980; 64:943-949. 7. Ensminger W, Niederhuber J, Dakhil S, et al: A totally implanted drug delivery system for hepatic arterial chemotherapy . Cancer Treat Rep 1981;65:393-400. 8. Dakhil S, Ensminger WD, Kindt G, et al: An implanted system for intra-ventricular drug infusion in central nervous system tumors . Cancer Treat Rep 1981;65:401-411. 9. Baker SR, Wheeler RH, Ensminger WB, et al: Intra-arterial infusion chemotherapy for head and neck cancer using a totally implantable infusion pump . Head Neck Surg 1981;4:118-124.Crossref 10. Baker SR, Wheeler RH: Long-term intra-arterial chemotherapy infusion of ambulatory head and neck cancer patients . J Surg Oncol 1982;21:125-131.Crossref 11. Buchwald H, Grage TB, Vassilopoulos PP, et al: Intra-arterial infusion chemotherapy for hepatic carcinoma using a totally implantable infusion pump . Cancer 1980;45:866-869.Crossref 12. Rohde TD, Blackshear PJ, Varco RL, et al: Protracted parenteral drug infusion in ambulatory subjects using an implantable infusion pump . Trans Am Soc Artif Intern Organs 1977;23:13-16.Crossref 13. Grant JCB, Batsmajian JV: Grant's Method of Anatomy , ed 7. Baltimore, Williams & Wilkins Co, 1965, p 621. 14. Liepman MK, Ensminger WB, Niederhuber J, et al: A novel injection system for intravenous chemotherapy administration . Proc Am Assoc Cancer Res Am Soc Chemother Oncol 1981; 22:419.
Archives of Otolaryngology – American Medical Association
Published: Nov 1, 1982