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Inner Ear Blood Flow Measured With a Laser Doppler System

Inner Ear Blood Flow Measured With a Laser Doppler System Abstract • Cochlear blood flow was studied in guinea pigs, using a laser Doppler system during exposure to methoxamine hydrochloride and phentolamine hydrochloride, local cooling, or terminal asphyxia. Measurements were made through the intact lateral wall of the first turn of the cochlea. Observed changes in relationship to simultaneous measures of skin blood flow and BP indicated that this system provides a dynamic measure of inner ear blood flow. This technique may provide a strategy to evaluate the role of blood flow in normal and pathologic cochlear function and the utility of presumed cochlear vasoeffective agents proposed for treatment of certain inner ear disorders. (Arch Otolaryngol 1984;110:305-308) References 1. Vertes D, Axelsson A, Lipscomb DM: Some vascular effects of noise exposure in the chinchilla cochlea . Arch Otorhinolaryngol 1979;224:97-101.Crossref 2. Nuttall AL, Hultcrantz E, Lawrence M: Does loud sound influence the intracochlear oxygen tension? Hear Res 1980;5:285-293.Crossref 3. Siegel LG: A national registry for idiopathic sudden deafness: Clinical study of a cochlear-vascular accident? in deLorenzo AJD (ed): Vascular Disorders and Hearing Defects . Baltimore, University Park Press, 1973, pp 307-319. 4. Axelsson A: The cochlear blood vessels in guinea pigs of different ages . Acta Otolaryngol 1971;72:172-181.Crossref 5. Sheehy JL: Vasodilator therapy in sensoryneural hearing loss . Laryngoscope 1960;70:885-914.Crossref 6. Mattox DE, Simmons FB: Natural history and sudden sensorineural hearing loss . Ann Otol 1977;86:463-480. 7. Maass B: Autonomic nervous system and hearing . Adv Otorhinolaryngol 1981;27:14-25. 8. Prazma J, Rodgers GK, Pillsbury HC: The effect of noise on cochlear blood flow. Read before the midwinter meeting of the Association for Research in Otolaryngology, St Petersburg, Fla, Jan 24, 1983. 9. Vertes D, Axelsson A: Methodological aspects of some inner ear vascular techniques . Acta Otolaryngol 1979;88:328-334.Crossref 10. Axelsson A, Angelborg C, Larsen HC: The microsphere surface for evaluation of cochlear vessels and circulation . Acta Otolaryngol 1983; 95:297-305.Crossref 11. Angelborg C, Hultcrantz E, Ȧgerup B: The cochlear blood flow . Acta Otolaryngol 1977;83:92-97.Crossref 12. Prazma J, Rodgers G: Measurement of cochlear blood flow: New techniques. Read before the 19th Annual Workshop on Biology of the Inner Ear, Mainz, West Germany, Sept 6, 1982. 13. Perlman HB, Kimura RA: Observations of the living blood vessels of the cochlea . Ann Otolaryngol 1955;64:1176-1192. 14. Lawrence M, Clapper M: Cine studies of organ of Corti blood supply , in deLorenzo AJD (ed): Vascular Disorders in Hearing Defects . Baltimore, University Park Press, 1973, pp 131-148. 15. Kraus EM, Babin RW, Ryu JH: Pulsed Doppler measurements of cochlear blood flow in response to dopamine in the anesthetized cat: A basis for dopamine treatment of sudden deafness. Read before the Research Forum of the American Academy of Otolaryngology—Head and Neck Surgery, New Orleans, Oct 16, 1982. 16. Miller JM, Marks NJ, Goodwin PC: Laser Doppler measurements of cochlear blood flow . Hear Res 1983;11:385-394.Crossref 17. Nilsson GE, Tenland T, Oberg PȦ: Evaluation of a laser Doppler flowmeter for measurement of tissue blood flow . IEEE Trans Biomed Eng 1980;27:597-604.Crossref 18. Bonner RF, Clem TR, Bowen PD, et al: Laser-Doppler continuous real-time monitor of pulsatile and mean blood flow in tissue microcirculation , in Chew SH, Chu B, Nossal R (eds): Scattering Techniques Applied to Supra Molecular and Non-equilibrium Systems , NATO Advanced Study Institute series B. New York, Plenum Press, 1981, vol 73, pp 685-70. 19. Marks NJ, Trachy RE, Cummings CW: Dynamic variations in blood flow as measured by laser Doppler velocimetry: A study in rat skin flaps. Read before the fall meeting of the American Academy of Facial Plastic and Reconstructive Surgery, New Orleans, Oct 16, 1982. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Otolaryngology American Medical Association

Inner Ear Blood Flow Measured With a Laser Doppler System

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Publisher
American Medical Association
Copyright
Copyright © 1984 American Medical Association. All Rights Reserved.
ISSN
0003-9977
DOI
10.1001/archotol.1984.00800310029006
Publisher site
See Article on Publisher Site

Abstract

Abstract • Cochlear blood flow was studied in guinea pigs, using a laser Doppler system during exposure to methoxamine hydrochloride and phentolamine hydrochloride, local cooling, or terminal asphyxia. Measurements were made through the intact lateral wall of the first turn of the cochlea. Observed changes in relationship to simultaneous measures of skin blood flow and BP indicated that this system provides a dynamic measure of inner ear blood flow. This technique may provide a strategy to evaluate the role of blood flow in normal and pathologic cochlear function and the utility of presumed cochlear vasoeffective agents proposed for treatment of certain inner ear disorders. (Arch Otolaryngol 1984;110:305-308) References 1. Vertes D, Axelsson A, Lipscomb DM: Some vascular effects of noise exposure in the chinchilla cochlea . Arch Otorhinolaryngol 1979;224:97-101.Crossref 2. Nuttall AL, Hultcrantz E, Lawrence M: Does loud sound influence the intracochlear oxygen tension? Hear Res 1980;5:285-293.Crossref 3. Siegel LG: A national registry for idiopathic sudden deafness: Clinical study of a cochlear-vascular accident? in deLorenzo AJD (ed): Vascular Disorders and Hearing Defects . Baltimore, University Park Press, 1973, pp 307-319. 4. Axelsson A: The cochlear blood vessels in guinea pigs of different ages . Acta Otolaryngol 1971;72:172-181.Crossref 5. Sheehy JL: Vasodilator therapy in sensoryneural hearing loss . Laryngoscope 1960;70:885-914.Crossref 6. Mattox DE, Simmons FB: Natural history and sudden sensorineural hearing loss . Ann Otol 1977;86:463-480. 7. Maass B: Autonomic nervous system and hearing . Adv Otorhinolaryngol 1981;27:14-25. 8. Prazma J, Rodgers GK, Pillsbury HC: The effect of noise on cochlear blood flow. Read before the midwinter meeting of the Association for Research in Otolaryngology, St Petersburg, Fla, Jan 24, 1983. 9. Vertes D, Axelsson A: Methodological aspects of some inner ear vascular techniques . Acta Otolaryngol 1979;88:328-334.Crossref 10. Axelsson A, Angelborg C, Larsen HC: The microsphere surface for evaluation of cochlear vessels and circulation . Acta Otolaryngol 1983; 95:297-305.Crossref 11. Angelborg C, Hultcrantz E, Ȧgerup B: The cochlear blood flow . Acta Otolaryngol 1977;83:92-97.Crossref 12. Prazma J, Rodgers G: Measurement of cochlear blood flow: New techniques. Read before the 19th Annual Workshop on Biology of the Inner Ear, Mainz, West Germany, Sept 6, 1982. 13. Perlman HB, Kimura RA: Observations of the living blood vessels of the cochlea . Ann Otolaryngol 1955;64:1176-1192. 14. Lawrence M, Clapper M: Cine studies of organ of Corti blood supply , in deLorenzo AJD (ed): Vascular Disorders in Hearing Defects . Baltimore, University Park Press, 1973, pp 131-148. 15. Kraus EM, Babin RW, Ryu JH: Pulsed Doppler measurements of cochlear blood flow in response to dopamine in the anesthetized cat: A basis for dopamine treatment of sudden deafness. Read before the Research Forum of the American Academy of Otolaryngology—Head and Neck Surgery, New Orleans, Oct 16, 1982. 16. Miller JM, Marks NJ, Goodwin PC: Laser Doppler measurements of cochlear blood flow . Hear Res 1983;11:385-394.Crossref 17. Nilsson GE, Tenland T, Oberg PȦ: Evaluation of a laser Doppler flowmeter for measurement of tissue blood flow . IEEE Trans Biomed Eng 1980;27:597-604.Crossref 18. Bonner RF, Clem TR, Bowen PD, et al: Laser-Doppler continuous real-time monitor of pulsatile and mean blood flow in tissue microcirculation , in Chew SH, Chu B, Nossal R (eds): Scattering Techniques Applied to Supra Molecular and Non-equilibrium Systems , NATO Advanced Study Institute series B. New York, Plenum Press, 1981, vol 73, pp 685-70. 19. Marks NJ, Trachy RE, Cummings CW: Dynamic variations in blood flow as measured by laser Doppler velocimetry: A study in rat skin flaps. Read before the fall meeting of the American Academy of Facial Plastic and Reconstructive Surgery, New Orleans, Oct 16, 1982.

Journal

Archives of OtolaryngologyAmerican Medical Association

Published: May 1, 1984

References