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Injection Therapy of Granuloma Annulare

Injection Therapy of Granuloma Annulare Abstract Granuloma annulare, a disease of unknown etiology and somewhat capricious behavior, has been the subject of numerous therapeutic approaches. Local measures have included mercurial plaster, tincture of iodine, iodine ointment, sulfur and salicylic acid preparations, radiation, carbon dioxide snow, dichloro-tetrafluoro-ethane (Frigiderm), electrocoagulation, electrolysis, and radial incisions. Systemic treatment has included bismuth, gold sodium thiosulphate, arsenic, calciferol, glycerinated extract of sheep blood, sulfonamides, penicillin, and measles immune serum. Massive doses of vitamin E and pantothenic acid derivatives have been recommended by Welsh.1 He suggested that the metabolic products of vitamin E may be utilized in the formation of cortisone-like materials and that calcium pantothenate may act as a biological catalyst in this process. Traub2 (in discussion of Welsh) raised the question as to whether the same results might be obtained by giving small injections of corticotropin. Carrying this reasoning one step further we wondered whether the injection of hydrocortisone References 1. Welsh, A. L.: Granuloma Annulare: Response to Massive Dose Therapy of Vitamin E Combined with Pantothenic Acid Derivatives , A.M.A. Arch. Dermat. & Syph. 70:468 ( (Oct.) ) 1954. 2. Traub, E. F., in discussion of Welsh, A. L.1 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Dermatology American Medical Association

Injection Therapy of Granuloma Annulare

Injection Therapy of Granuloma Annulare

Abstract

Abstract Granuloma annulare, a disease of unknown etiology and somewhat capricious behavior, has been the subject of numerous therapeutic approaches. Local measures have included mercurial plaster, tincture of iodine, iodine ointment, sulfur and salicylic acid preparations, radiation, carbon dioxide snow, dichloro-tetrafluoro-ethane (Frigiderm), electrocoagulation, electrolysis, and radial incisions. Systemic treatment has included bismuth, gold sodium thiosulphate, arsenic, calciferol,...
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Publisher
American Medical Association
Copyright
Copyright © 1960 American Medical Association. All Rights Reserved.
ISSN
0096-5359
DOI
10.1001/archderm.1960.03730060085016
Publisher site
See Article on Publisher Site

Abstract

Abstract Granuloma annulare, a disease of unknown etiology and somewhat capricious behavior, has been the subject of numerous therapeutic approaches. Local measures have included mercurial plaster, tincture of iodine, iodine ointment, sulfur and salicylic acid preparations, radiation, carbon dioxide snow, dichloro-tetrafluoro-ethane (Frigiderm), electrocoagulation, electrolysis, and radial incisions. Systemic treatment has included bismuth, gold sodium thiosulphate, arsenic, calciferol, glycerinated extract of sheep blood, sulfonamides, penicillin, and measles immune serum. Massive doses of vitamin E and pantothenic acid derivatives have been recommended by Welsh.1 He suggested that the metabolic products of vitamin E may be utilized in the formation of cortisone-like materials and that calcium pantothenate may act as a biological catalyst in this process. Traub2 (in discussion of Welsh) raised the question as to whether the same results might be obtained by giving small injections of corticotropin. Carrying this reasoning one step further we wondered whether the injection of hydrocortisone References 1. Welsh, A. L.: Granuloma Annulare: Response to Massive Dose Therapy of Vitamin E Combined with Pantothenic Acid Derivatives , A.M.A. Arch. Dermat. & Syph. 70:468 ( (Oct.) ) 1954. 2. Traub, E. F., in discussion of Welsh, A. L.1

Journal

A.M.A. Archives of DermatologyAmerican Medical Association

Published: Jun 1, 1960

References