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Injection of Hydrocortisone into Dermatologic Lesions

Injection of Hydrocortisone into Dermatologic Lesions Abstract The author's successful clearing of lesions of necrobiosis lipoidica diabeticorum1 by injections of hydrocortisone acetate prompted an 18-month clinical investigation into the effect of injecting hydrocortisone into other dermatologic lesions. Several other investigators have reported their results following injection of hydrocortisone into skin lesions. Sullivan2 found that lesions of sarcoidosis responded better to injections of hydrocortisone than to cortisone. Zachariae and Zachariae3 reported improvement of Dupuytren's contracture and Peyronie's disease after injections of hydrocortisone acetate. J. Graham Smith4 also reported 50% improvement in one case of necrobiosis lipoidica diabeticorum after the local injection of hydrocortisone and cited three other instances of similar improvement. In one case of localized myxedema reported by Forsey and Anhalt5 injections of hydrocortisone cleared the lesions after hyaluronidase had failed; in another case, hydrocortisone and hyaluronidase used simultaneously cleared lesions which had resisted them when used separately. Buchholz References 1. Solu-Cortef and Cortef acetate were provided by the Upjohn Company, Kalamazoo, Mich. The former preparation is being used for intravenous administration when rapid and intense hormonal effect is necessary as in acute adrenal cortical insufficiency, shock unresponsive to standard antishock therapy, status asthmaticus, and allergic drug reactions.8 2. M. E. Obermayer, M.D. and Maxwell Wolff, M.D., Co-Chairmen of the Department of Dermatology. 3. Savitt, L. E.: Favorable Response of Necrobiosis Lipoidica Diabeticorum to Hydrocortisone Suspension , A. M. A. Arch. Dermat. 71:506 ( (April) ) 1955.Crossref 4. Sullivan, R. D.; Mayock, R. L.; Jones, R. Jr., and Beerman, H.: Local Injection of Hydrocortisone and Cortisone into Skin Lesions of Sarcoidosis , J. A. M. A. 152:308 ( (May 23) ) 1953.Crossref 5. Zachariae, L., and Zachariae, F.: Hydrocortisone Acetate in the Treatment of Dupuytren's Contraction and Allied Conditions , Acta chir. scandinav. 109:421 (No. (6) ) 1955 (in English). 6. Smith, J. G. Jr.: Necrobiosis Lipoidica , A. M. A. Arch. Dermat. 74:280 ( (Sept) ) 1956.Crossref 7. Forsey, R. R., and Anhalt, A. W.: Hydrocortisone in the Treatment of Localized Myxedema , A. M. A. Arch. Dermat. 74:352 ( (Oct.) ) 1956.Crossref 8. Buchholz, A.: Treatment of Chondrodermatitis Helicis with Local Injections of Hydrocortisone , A. M. A. Arch. Dermat. 74:547 ( (Nov.) ) 1956.Crossref 9. Zachariae, L., and Asboe-Hansen, G.: Regression of Experimental Skin Tumors in Mice Following Local Injections of 17-Hydroxycortcosterone-21-Acetate , Cancer Research 14:488 ( (Aug.) ) 1954. 10. Hart, F. D.: Clinical Uses of Intravenous Hydrocortisone , Brit. M. J. 1:454-455 ( (Feb. 19) ) 1955.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Dermatology American Medical Association

Injection of Hydrocortisone into Dermatologic Lesions

A.M.A. Archives of Dermatology , Volume 76 (6) – Dec 1, 1957

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Publisher
American Medical Association
Copyright
Copyright © 1957 American Medical Association. All Rights Reserved.
ISSN
0096-5359
DOI
10.1001/archderm.1957.01550240098021
Publisher site
See Article on Publisher Site

Abstract

Abstract The author's successful clearing of lesions of necrobiosis lipoidica diabeticorum1 by injections of hydrocortisone acetate prompted an 18-month clinical investigation into the effect of injecting hydrocortisone into other dermatologic lesions. Several other investigators have reported their results following injection of hydrocortisone into skin lesions. Sullivan2 found that lesions of sarcoidosis responded better to injections of hydrocortisone than to cortisone. Zachariae and Zachariae3 reported improvement of Dupuytren's contracture and Peyronie's disease after injections of hydrocortisone acetate. J. Graham Smith4 also reported 50% improvement in one case of necrobiosis lipoidica diabeticorum after the local injection of hydrocortisone and cited three other instances of similar improvement. In one case of localized myxedema reported by Forsey and Anhalt5 injections of hydrocortisone cleared the lesions after hyaluronidase had failed; in another case, hydrocortisone and hyaluronidase used simultaneously cleared lesions which had resisted them when used separately. Buchholz References 1. Solu-Cortef and Cortef acetate were provided by the Upjohn Company, Kalamazoo, Mich. The former preparation is being used for intravenous administration when rapid and intense hormonal effect is necessary as in acute adrenal cortical insufficiency, shock unresponsive to standard antishock therapy, status asthmaticus, and allergic drug reactions.8 2. M. E. Obermayer, M.D. and Maxwell Wolff, M.D., Co-Chairmen of the Department of Dermatology. 3. Savitt, L. E.: Favorable Response of Necrobiosis Lipoidica Diabeticorum to Hydrocortisone Suspension , A. M. A. Arch. Dermat. 71:506 ( (April) ) 1955.Crossref 4. Sullivan, R. D.; Mayock, R. L.; Jones, R. Jr., and Beerman, H.: Local Injection of Hydrocortisone and Cortisone into Skin Lesions of Sarcoidosis , J. A. M. A. 152:308 ( (May 23) ) 1953.Crossref 5. Zachariae, L., and Zachariae, F.: Hydrocortisone Acetate in the Treatment of Dupuytren's Contraction and Allied Conditions , Acta chir. scandinav. 109:421 (No. (6) ) 1955 (in English). 6. Smith, J. G. Jr.: Necrobiosis Lipoidica , A. M. A. Arch. Dermat. 74:280 ( (Sept) ) 1956.Crossref 7. Forsey, R. R., and Anhalt, A. W.: Hydrocortisone in the Treatment of Localized Myxedema , A. M. A. Arch. Dermat. 74:352 ( (Oct.) ) 1956.Crossref 8. Buchholz, A.: Treatment of Chondrodermatitis Helicis with Local Injections of Hydrocortisone , A. M. A. Arch. Dermat. 74:547 ( (Nov.) ) 1956.Crossref 9. Zachariae, L., and Asboe-Hansen, G.: Regression of Experimental Skin Tumors in Mice Following Local Injections of 17-Hydroxycortcosterone-21-Acetate , Cancer Research 14:488 ( (Aug.) ) 1954. 10. Hart, F. D.: Clinical Uses of Intravenous Hydrocortisone , Brit. M. J. 1:454-455 ( (Feb. 19) ) 1955.Crossref

Journal

A.M.A. Archives of DermatologyAmerican Medical Association

Published: Dec 1, 1957

References