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Inhibition of Salt Excretion by Carbohydrate

Inhibition of Salt Excretion by Carbohydrate Abstract A recent report1 from this laboratory has demonstrated a greater sodium excretion during fasting than would be expected during a comparable period on a salt-free diet. These observations might suggest that either food in general or some constituent of the diet might be involved in the regulation of sodium excretion. Gamble2 had previously shown that glucose or food diminished the sodium excretion of life raft survivors. That study compared a period of salt-free nutrition with glucose with a period of fasting, using the subject as his own control. The present investigation is concerned with the effects of dietary constituents (sodium chloride, carbohydrate, or protein and fat) on the established pattern of salt excretion of fasting. It has been observed by Gamble2 as well as Hervey and McCance3 that less sodium was excreted in the urine when periods of carbohydrate intake in amounts insufficient for caloric needs References 1. Bloom, W. L., and Mitchell, W.: Salt Excretion of Fasting Patients , Arch. Intern. Med. 106: 321, 1960.Crossref 2. Gamble, J. L.; Ross, G. S., and Tisdall, F. F.: The Metabolism of Fixed Base During Fasting , J. Biol. Chem. 57:633, 1923. 3. Hervey, G. R., and McCance, R. A.: The Effects of Carbohydrate and Sea Water on the Metabolism of Men Without Food or Sufficient Water , Proc. Roy. Soc. (Biol.) 139:527, 1952.Crossref 4. Newburgh, L. H.: Obesity , Arch. Intern. Med. 70:1033, 1942.Crossref 5. Werner, S. C.: Comparison Between Weight Reduction on a High-Caloric, High-Fat Diet and on an Isocaloric Regimen High in Carbohydrate , New Engl. J. Med. 252:661, 1955.Crossref 6. Keckwick, A., and Pawan, G. L. S.: Metabolic Study in Human Obesity with Isocaloric Diets High in Fat, Protein or Carbohydrate , Metabolism 6:447, 1957. 7. Atchley, D. W.; Loeb, R. F.; Richards, D. W., Jr.; Benedict, E. M., and Driscoll, M. E.: On Diabetic Acidosis , J. Clin. Invest. 12:297, 1933.Crossref 8. Elwyn, H.: Edema and Its Treatment , New York, The Macmillan Company, 1929. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Inhibition of Salt Excretion by Carbohydrate

Archives of Internal Medicine , Volume 109 (1) – Jan 1, 1962

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Publisher
American Medical Association
Copyright
Copyright © 1962 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1962.03620130028004
Publisher site
See Article on Publisher Site

Abstract

Abstract A recent report1 from this laboratory has demonstrated a greater sodium excretion during fasting than would be expected during a comparable period on a salt-free diet. These observations might suggest that either food in general or some constituent of the diet might be involved in the regulation of sodium excretion. Gamble2 had previously shown that glucose or food diminished the sodium excretion of life raft survivors. That study compared a period of salt-free nutrition with glucose with a period of fasting, using the subject as his own control. The present investigation is concerned with the effects of dietary constituents (sodium chloride, carbohydrate, or protein and fat) on the established pattern of salt excretion of fasting. It has been observed by Gamble2 as well as Hervey and McCance3 that less sodium was excreted in the urine when periods of carbohydrate intake in amounts insufficient for caloric needs References 1. Bloom, W. L., and Mitchell, W.: Salt Excretion of Fasting Patients , Arch. Intern. Med. 106: 321, 1960.Crossref 2. Gamble, J. L.; Ross, G. S., and Tisdall, F. F.: The Metabolism of Fixed Base During Fasting , J. Biol. Chem. 57:633, 1923. 3. Hervey, G. R., and McCance, R. A.: The Effects of Carbohydrate and Sea Water on the Metabolism of Men Without Food or Sufficient Water , Proc. Roy. Soc. (Biol.) 139:527, 1952.Crossref 4. Newburgh, L. H.: Obesity , Arch. Intern. Med. 70:1033, 1942.Crossref 5. Werner, S. C.: Comparison Between Weight Reduction on a High-Caloric, High-Fat Diet and on an Isocaloric Regimen High in Carbohydrate , New Engl. J. Med. 252:661, 1955.Crossref 6. Keckwick, A., and Pawan, G. L. S.: Metabolic Study in Human Obesity with Isocaloric Diets High in Fat, Protein or Carbohydrate , Metabolism 6:447, 1957. 7. Atchley, D. W.; Loeb, R. F.; Richards, D. W., Jr.; Benedict, E. M., and Driscoll, M. E.: On Diabetic Acidosis , J. Clin. Invest. 12:297, 1933.Crossref 8. Elwyn, H.: Edema and Its Treatment , New York, The Macmillan Company, 1929.

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Jan 1, 1962

References